Expression of Acetylcholine and Its Receptor in Human Sympathetic Ganglia in Primary Hyperhidrosis

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art_MOURA JUNIOR_Expression_of_Acetylcholine_and_Its_Receptor_in_Human_2013.PDF (1.9 MB)
Citações na Scopus
39
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
DAS-NEVES-PEREIRA, Joao C.
Citação
ANNALS OF THORACIC SURGERY, v.95, n.2, p.465-471, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background. The pathophysiologic characteristics of primary hyperhidrosis are not well understood and seem to be related to a sympathetic nervous system dysfunction. The resection of thoracic sympathetic chain ganglia is the most effective treatment for hyperhidrosis; however sympathetic ganglia function in normal individuals and in patients with hyperhidrosis is unknown. Methods. A cross-sectional study, in which 2 groups of 20 subjects were analyzed: the hyperhidrosis group (HYP), comprised of patients with hyperhidrosis who were eligible for thoracic sympathectomy, and the control group (CON) comprised of brain-dead organ donors without a history of hyperhidrosis. For each subject, the following were performed: resection of the third left sympathetic ganglion, measurement of the ganglion's diameter, and immunohistochemical evaluation by quantification of strong and weak expression areas of primary antibodies against acetylcholine and alpha-7 neuronal nicotinic receptor subunit. Results. The presence of a strong alpha-7 subunit expression area was 4.85% in patients with primary hyperhidrosis and 2.34% in controls (p < 0.001), whereas the presence of a weak expression area was 11.48% in the HYP group and 4.59% in the CON group (p < 0.001). Strong acetylcholine expression was found in 4.95% of the total area in the HYP group and in 1.19% in the CON group (p < 0.001), whereas weak expression was found in 18.55% and 6.77% of the HYP and CON groups, respectively (p < 0.001). Furthermore, diameter of the ganglia was 0.71 cm in the HYP group and 0.53 cm in the CON group (p < 0.001). Conclusions. There is a higher expression of acetylcholine and alpha-7 neuronal nicotinic receptor subunit in the sympathetic ganglia of patients with hyperhidrosis. Furthermore, the diameter of the thoracic sympathetic chain ganglia is larger in such patients. (Ann Thorac Surg 2013;95:465-71) (c) 2013 by The Society of Thoracic Surgeons
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URI
https://observatorio.fm.usp.br/handle/OPI/1842
Referências
  1. Bovell DL, 2001, BRIT J DERMATOL, V145, P298, DOI 10.1046/j.1365-2133.2001.04351.x
  2. Cina CS, 1999, QUAL LIFE RES, V8, P693, DOI 10.1023/A:1008968401068
  3. Cruz J, 2009, J THORAC CARDIOV SUR, V137, P664, DOI 10.1016/j.jtcvs.2008.07.021
  4. de Moura NB, 2013, ANN THORAC SURG, V95, P465, DOI 10.1016/j.athoracsur.2012.10.068
  5. De Biasi M, 2002, J NEUROBIOL, V53, P568, DOI 10.1002/neu.10145
  6. de Campos JRM, 2003, ANN THORAC SURG, V76, P886
  7. de Moura NB, 2012, MOL NEUROBIOL, V45, P362, DOI 10.1007/s12035-012-8235-3
  8. Eccles JC, 1935, J PHYSIOL-LONDON, V85, P207
  9. Eisenach JH, 2005, MAYO CLIN PROC, V80, P657
  10. Gan WB, 2003, NAT NEUROSCI, V6, P956, DOI 10.1038/nn1115
  11. Hornberger J, 2004, J AM ACAD DERMATOL, V51, P274, DOI 10.1016/j.jaad.2003.12.029
  12. Ishy A, 2011, INTERACT CARDIOV TH, V12, P545, DOI 10.1510/icvts.2010.252015
  13. Kauffman P, 2007, J BRAS PNEUMOL, V33, P15
  14. Kirstein SL, 2004, PHARMACOL REV, V56, P31, DOI 10.1124/pr.56.1.2.
  15. Krasna MJ, 2008, ANN THORAC SURG, V85, pS764, DOI 10.1016/j.athoracsur.2007.12.005
  16. Manca D, 2000, CLIN NEUROPHYSIOL, V111, P1767, DOI 10.1016/S1388-2457(00)00394-1
  17. Moraes Edvaldo Leal de, 2009, Rev Lat Am Enfermagem, V17, P716
  18. SARGENT PB, 1993, ANNU REV NEUROSCI, V16, P403, DOI 10.1146/annurev.ne.16.030193.002155
  19. SATO K, 1989, J AM ACAD DERMATOL, V20, P713, DOI 10.1016/S0190-9622(89)70081-5
  20. Shafton AD, 2003, BRAIN RES, V652, P129
  21. Skok VI, 2002, AUTON NEUROSCI-BASIC, V97, P1, DOI 10.1016/S1566-0702(01)00386-1
  22. Strutton DR, 2004, J AM ACAD DERMATOL, V51, P241, DOI 10.1016/j.jaad.2003.12.040
  23. Xu W, 1999, P NATL ACAD SCI USA, V96, P5746, DOI 10.1073/pnas.96.10.5746
  24. Yazbek G, 2005, J VASC SURG, V42, P281, DOI 10.1016/j.jvs.2005.03.041

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCP
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/02
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