Pregnancy in Women Previously Treated for an Adrenocortical Carcinoma

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCORBIERE, Pauline de
dc.contributor.authorRITZEL, Katrin
dc.contributor.authorCAZABAT, Laure
dc.contributor.authorROPERS, Jacques
dc.contributor.authorSCHOTT, Matthias
dc.contributor.authorLIBE, Rosella
dc.contributor.authorKOSCHKER, Ann-Cathrin
dc.contributor.authorLEBOULLEUX, Sophie
dc.contributor.authorDEUTSCHBEIN, Timo
dc.contributor.authorCAO, Christine Do
dc.contributor.authorHAHNER, Stefanie
dc.contributor.authorDRUI, Delphine
dc.contributor.authorMIEHLE, Konstanze
dc.contributor.authorCARON, Philippe
dc.contributor.authorWALDMANN, Jens
dc.contributor.authorCHABRE, Olivier
dc.contributor.authorQUINKLER, Marcus
dc.contributor.authorTOURAINE, Philippe
dc.contributor.authorFRAGOSO, Maria C. Villares
dc.contributor.authorBERTHERAT, Jerome
dc.contributor.authorBERTAGNA, Xavier
dc.contributor.authorFASSNACHT, Martin
dc.contributor.authorRAFFIN-SANSON, Marie-Laure
dc.date.accessioned2016-03-14T14:31:44Z
dc.date.available2016-03-14T14:31:44Z
dc.date.issued2015
dc.description.abstractContext: Adrenocortical carcinomas (ACCs) are rare, aggressive tumors, of which some express receptors for estradiol, progesterone, and/or human chorionic gonadotoropin. Because this disease is encountered frequently in young women, pregnancy is a relevant issue. Objective: to evaluate the impact of pregnancy on outcome of patients previously treated for ACC. Design/Setting: retrospective observational multicenter study of the European Network for the Study of Adrenal Tumors. Patients: Seventeen ACC patients (21 pregnancies), becoming pregnant at least 3 months after the initial treatment, were compared with 247 nonpregnant ACC patients less than 47 years old. A control group of 34 patients matched for age, sex, and tumor stage was used for survival analysis. Main Outcome Measure(s): Overall survival, tumors characteristics at diagnosis, pregnancy outcome. Results: All 17 patients with pregnancies had localized ACC. The median time between surgery and conception was 4 years (0.3-12 y). Two pregnancies were terminated at 8 weeks. Sixteen women gave birth to 19 live infants. With exception of 1 (presumably unrelated) cardiac malformation, no severe fetal or maternal complication was observed. After a median follow-up time of 8.36 years and 5.26 years after the first conception, 1 of the 17 patients had died and 5 had experienced a recurrence, among whom 3 occurred before conception. Overall survival was not significantly different between the ""pregnancy group"" and the matched controls. Conclusion: Pregnancy in patients previously treated forACCseems to not be associated with worse clinical outcome, although a ""healthy mother effect"" cannot be excluded.
dc.description.indexMEDLINE
dc.description.sponsorshipEuropean Network for the Study of Adrenocortical Tumors
dc.description.sponsorshipEuropean Union [259735]
dc.description.sponsorshipDeutsche Forschungsgemeinschaft [FA 466/4-1]
dc.identifier.citationJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v.100, n.12, p.4604-4611, 2015
dc.identifier.doi10.1210/jc.2015-2341
dc.identifier.eissn1945-7197
dc.identifier.issn0021-972X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13567
dc.language.isoeng
dc.publisherENDOCRINE SOC
dc.relation.ispartofJournal of Clinical Endocrinology & Metabolism
dc.rightsrestrictedAccess
dc.rights.holderCopyright ENDOCRINE SOC
dc.subject.othercushings-syndrome
dc.subject.otherbreast-cancer
dc.subject.otheradrenal carcinoma
dc.subject.otherexpression
dc.subject.otherreceptor
dc.subject.othersurvival
dc.subject.othermitotane
dc.subject.othertumorigenesis
dc.subject.othermetaanalysis
dc.subject.otherprognosis
dc.subject.wosEndocrinology & Metabolism
dc.titlePregnancy in Women Previously Treated for an Adrenocortical Carcinoma
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryisofr
hcfmusp.affiliation.countryisode
hcfmusp.author.externalCORBIERE, Pauline de:Ambroise Pare Univ Hosp, AP HP, Dept Endocrinol, F-92100 Boulogne, France
hcfmusp.author.externalRITZEL, Katrin:Klinikum Univ Munchen, Med Klin 4, D-80336 Munich, Germany
hcfmusp.author.externalCAZABAT, Laure:Ambroise Pare Univ Hosp, AP HP, Dept Endocrinol, F-92100 Boulogne, France; Univ Versailles St Quentin En Yvelines, INSERM, U1173, F-78280 Montigny Le Bretonneux, France
hcfmusp.author.externalROPERS, Jacques:Hop Ambroise Pare, AP HP, Hosp Univ Paris Ile De France Ouest, Unite Rech Clin, F-92100 Boulogne, France
hcfmusp.author.externalSCHOTT, Matthias:Univ Klinikum Dusseldorf, Funkt Bereich Spezielle Endokrinol, D-40225 Dusseldorf, Germany
hcfmusp.author.externalLIBE, Rosella:Cochin Univ Hosp, AP HP, French Adrenal Canc Network COrtico MEdullo Surre, Dept Endocrinol, F-75014 Paris, France
hcfmusp.author.externalKOSCHKER, Ann-Cathrin:Inst Cochin, Unite Mixte Rech 8104, F-75014 Paris, France
hcfmusp.author.externalLEBOULLEUX, Sophie:Univ Wurzburg, Comprehens Canc Ctr Mainfranken, D-97080 Wurzburg, Germany
hcfmusp.author.externalDEUTSCHBEIN, Timo:Inst Gustave Roussy, F-94800 Villejuif, France
hcfmusp.author.externalCAO, Christine Do:Univ Wurzburg, Univ Hosp, Endocrine Unit, Dept Med, D-97080 Wurzburg, Germany
hcfmusp.author.externalHAHNER, Stefanie:Ctr Hosp Reg Univ Lille, F-59000 Lille, France
hcfmusp.author.externalDRUI, Delphine:Univ Wurzburg, Univ Hosp, Dept Med 1, Endocrinol & Diabet Unit, D-97080 Wurzburg, Germany
hcfmusp.author.externalMIEHLE, Konstanze:Nantes Univ Hosp, Dept Endocrinol, F-44000 Nantes, France
hcfmusp.author.externalCARON, Philippe:Univ Leipzig, Dept Endocrinol & Nephrol, D-04357 Leipzig, Germany
hcfmusp.author.externalWALDMANN, Jens:Ctr Hosp Univ Larrey, Pole Cardio Vasc & Metab, Serv Endocrinol Malad Metab & Nutr, F-10623 Toulouse, France
hcfmusp.author.externalCHABRE, Olivier:Univ Hosp Giessen & Marburg, Div Endocrinol & Diabetol, D-35041 Marburg, Germany
hcfmusp.author.externalQUINKLER, Marcus:Michallon Teaching Hosp, Dept Endocrinol, F-38043 Grenoble, France
hcfmusp.author.externalTOURAINE, Philippe:Endocrinol Charlottenburg, D-10623 Berlin, Germany
hcfmusp.author.externalBERTHERAT, Jerome:Cochin Univ Hosp, AP HP, French Adrenal Canc Network COrtico MEdullo Surre, Dept Endocrinol, F-75014 Paris, France
hcfmusp.author.externalBERTAGNA, Xavier:Cochin Univ Hosp, AP HP, French Adrenal Canc Network COrtico MEdullo Surre, Dept Endocrinol, F-75014 Paris, France
hcfmusp.author.externalFASSNACHT, Martin:Klinikum Univ Munchen, Med Klin 4, D-80336 Munich, Germany; Inst Cochin, Unite Mixte Rech 8104, F-75014 Paris, France; Inst Gustave Roussy, F-94800 Villejuif, France
hcfmusp.author.externalRAFFIN-SANSON, Marie-Laure:Ambroise Pare Univ Hosp, AP HP, Dept Endocrinol, F-92100 Boulogne, France; Univ Versailles St Quentin En Yvelines, INSERM, U1173, F-78280 Montigny Le Bretonneux, France
hcfmusp.citation.scopus15
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.description.beginpage4604
hcfmusp.description.endpage4611
hcfmusp.description.issue12
hcfmusp.description.volume100
hcfmusp.origemWOS
hcfmusp.origem.pubmed26461265
hcfmusp.origem.scopus2-s2.0-84950991927
hcfmusp.origem.wosWOS:000368428600042
hcfmusp.publisher.cityWASHINGTON
hcfmusp.publisher.countryUSA
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