Effect of smoking cessation in saliva compounds by FTIR spectroscopy

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art_RODRIGUES_Effect_of_smoking_cessation_in_saliva_compounds_by_2017.PDF (631.38 KB)
Citações na Scopus
27
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
RODRIGUES, Lais Morandini
MAGRINI, Taciana Depra
LIMA, Celina Faig
MARTINHO, Herculano da Silva
ALMEIDA, Janete Dias
Citação
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, v.174, p.124-129, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Introduction: Smoking is currently considered one of the biggest risk factors for the development of various diseases and early death. Fourier transform infrared (FTIR) spectroscopy is a valuable tool for analysis of biofluids such as saliva and is considered useful for diagnostic purposes. The aim of this study was to evaluate the effect of smoking cessation on saliva composition by FTIR spectroscopy. Methods: We analyzed the saliva of participants in two groups: a smoker group made up of 10 chronic smokers and a former smoker group made up of 10 individuals who had stopped smoking. Members of both groups had similar smoking history. Results: The results showed few differences in spectral intensity between the groups; however, spectral peaks were slightly increased in the group of smokers in the bands for DNA, indicating modification of its content or cell necrosis. They were also increased for the mannose-6-phosphatase molecule, which is expressed in prostate and breast carcinomas. In the former smoker group, the peak of thyociante was decreased and the band referring to collagen increased in intensity, which indicates a better tissue regeneration capacity. Conclusion: Considering these results and the fact that tobacco intake was similar between the groups, it can be concluded that there was recovery of tissue regeneration capacity with smoking cessation during the study period, although the effects found in smokers persisted in the bodies of those who had given up smoking.
Palavras-chave
Saliva, FTIR spectroscopy, Tobacco, Smoking cessation
URI
https://observatorio.fm.usp.br/handle/OPI/19063
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - ODS/03