Immunoexpression of adhesion molecules during human fetal hair development

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Laura Maria Andrade
dc.contributor.authorHSIEH, Ricardo
dc.contributor.authorLOURENCO, Silvia Vanessa
dc.contributor.authorOTTONI, Veronica
dc.contributor.authorVALENTE, Neusa
dc.contributor.authorFERNANDES, Juliana Dumet
dc.date.accessioned2020-10-15T14:46:36Z
dc.date.available2020-10-15T14:46:36Z
dc.date.issued2020
dc.description.abstractIntroduction. Hair follicles are produced in a cyclical manner and the machinery involved in the reproduction of these follicles is present since the fetal stage. Although extensive research has been done on the human hair follicle, very little is known about the importance of adhesion molecules in its development. Material and methods. We analyzed here, the immunoexpression of beta-1 integrin, p-cadherin, e-cadherin, and beta-catenin in hair follicles from 26 formalin-fixed and paraffin-embedded skin samples from human embryos and fetus between 12-23 weeks of gestational age. Results. The adhesion molecules beta-1 integrin and e-cadherin/p-cadherin were expressed from 12 weeks and seemed to play a role in regulating epidermis invagination. Beta-catenin immunostaining was negative in all cases; down regulation of this protein may be necessary for fetal hair development and thus facilitating hair follicle down growth. Discussion/Conclusion. Adhesion molecules are essential for hair follicle down growth and proliferation; integrins and cadherins play a major role in this process. More studies are needed to describe hair follicle development.eng
dc.description.indexMEDLINEeng
dc.description.sponsorship- [-] Funding Source: Medline
dc.identifier.citationHISTOLOGY AND HISTOPATHOLOGY, v.35, n.8, p.911-917, 2020
dc.identifier.doi10.14670/HH-18-224
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/37981
dc.language.isoeng
dc.publisherF HERNANDEZeng
dc.relation.ispartofHistology and Histopathology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright F HERNANDEZeng
dc.subjectAdhesion moleculeseng
dc.subjectHair follicleeng
dc.subjectFetal developmenteng
dc.subjectImmunohistochemistryeng
dc.subject.otherbeta-catenineng
dc.subject.othere-cadherineng
dc.subject.otherfollicle developmenteng
dc.subject.otherp-cadherineng
dc.subject.otherstem-cellseng
dc.subject.otherexpressioneng
dc.subject.othermarkerseng
dc.subject.otherskineng
dc.subject.otherroleseng
dc.subject.wosCell Biologyeng
dc.subject.wosPathologyeng
dc.titleImmunoexpression of adhesion molecules during human fetal hair developmenteng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSILVA, Laura Maria Andrade:Univ Fed Bahia, Sch Med, Postgrad Program Med & Hlth, Salvador, BA, Brazil
hcfmusp.author.externalLOURENCO, Silvia Vanessa:Univ Sao Paulo, Sch Dent, Stomatol Dept, Sao Paulo, Brazil
hcfmusp.author.externalFERNANDES, Juliana Dumet:Univ Fed Bahia, Sch Med, Postgrad Program Med & Hlth, Salvador, BA, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcRICARDO HSIEH
hcfmusp.contributor.author-fmusphcVERONICA ESTER RODRIGUES OTONI SILVA
hcfmusp.contributor.author-fmusphcNEUSA YURIKO SAKAI VALENTE
hcfmusp.description.beginpage911
hcfmusp.description.endpage917
hcfmusp.description.issue8
hcfmusp.description.volume35
hcfmusp.origemWOS
hcfmusp.origem.pubmed32364615
hcfmusp.origem.scopus2-s2.0-85090493067
hcfmusp.origem.wosWOS:000557879000014
hcfmusp.publisher.cityMURCIAeng
hcfmusp.publisher.countrySPAINeng
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