CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators?

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art_IANEZ_CD24_and_CD44_in_salivary_gland_pleomorphic_adenoma_2013.PDF (1.28 MB)
Citações na Scopus
11
Tipo de produção
article
Data de publicação
2013
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
IANEZ, Renata C. F.
COUTINHO-CAMILLO, Claudia M.
BUIM, Marcilei E.
PINTO, Clovis A. L.
SOARES, Fernando A.
Citação
HISTOPATHOLOGY, v.62, n.7, p.1075-1082, 2013
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aims Salivary gland neoplasms originate from salivary gland compartments, to which they are histologically related. Pleomorphic adenoma (PA) is a benign salivary gland neoplasm that comprises epithelial and myoepithelial cells and a complex stroma, whose structure, architecture and origin (from intercalated ducts) suggest stem cell participation. We compared the expression of CD24 and CD44 in PA and in developing human salivary glands to investigate whether these markers can be considered as cancer stem cell markers. Methods and results One hundred and one cases of PA and salivary gland specimens from 20 human fetuses were examined by immunohistochemistry and real-time reverse transcription polymerase chain reaction (RT-PCR). All PAs were positive for CD24 and CD44 by immunohistochemistry: neoplastic luminal structures were positive for CD24; modified myoepithelial cells were positive for CD44. In fetal salivary glands, these markers were restricted to the intercalated duct region. Real-time RT-PCR assays detected increased expression of CD44, but not CD24, in PA specimens in comparison with normal salivary gland controls. Conclusions PA and stem cells share the expression of CD24 and CD44; their value as markers of neoplastic cell multipotency and the implications of their expression for tumour behaviour are yet to be determined.
Palavras-chave
CD24, CD44, pleomorphic adenoma, salivary glands, stem cells
URI
https://observatorio.fm.usp.br/handle/OPI/7856
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Coleções
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - ODS/03