Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEAL, Elcio
dc.contributor.authorLUCHS, Adriana
dc.contributor.authorMILAGRES, Flavio Augusto de Padua
dc.contributor.authorKOMNINAKIS, Shirley Vasconcelos
dc.contributor.authorGILL, Danielle Elise
dc.contributor.authorLOBATO, Marcia Cristina Alves Brito Sayao
dc.contributor.authorBRUSTULIN, Rafael
dc.contributor.authorCHAGAS, Rogerio Togisaki das
dc.contributor.authorABRAO, Maria de Fatima Neves dos Santos
dc.contributor.authorSOARES, Cassia Vitoria de Deus Alves
dc.contributor.authorVILLANOVA, Fabiola
dc.contributor.authorWITKIN, Steven S.
dc.contributor.authorDENG, Xutao
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorDELWART, Eric
dc.contributor.authorCOSTA, Antonio Charlys da
dc.date.accessioned2019-08-20T14:44:52Z
dc.date.available2019-08-20T14:44:52Z
dc.date.issued2019
dc.description.abstractWe characterized the 24 nearly full-length genomes of human parechoviruses (PeV) from children in the north of Brazil. The initial phylogenetic analysis indicated that 17 strains belonged to genotype 1, 5 to genotype 4, and 1 to genotype 17. A more detailed analysis revealed a high frequency of recombinant strains (58%): A total of 14 of our PeV-As were chimeric, with four distinct recombination patterns identified. Five strains were composed of genotypes 1 and 5 (Rec1/5); five strains shared a complex mosaic pattern formed by genotypes 4, 5, and 17 (Rec4/17/5); two strains were composed of genotypes 1 and 17 (Rec1/17); and two strains were composed of genotype 1 and an undetermined strain (Rec1/und). Coalescent analysis based on the Vp1 gene, which is free of recombination, indicated that the recombinant strains most likely arose in this region approximately 30 years ago. They are present in high frequencies and are circulating in different small and isolated cities in the state of Tocantins. Further studies will be needed to establish whether the detected recombinant strains have been replacing parental strains or if they are co-circulating in distinct frequencies in Tocantins.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESP [2015/12944-9, 2016/01735-2, 2017/00021-9]
dc.description.sponsorshipCNPq [400354/2016-0]
dc.identifier.citationVIRUSES-BASEL, v.11, n.6, 2019
dc.identifier.doi10.3390/v11060488
dc.identifier.issn1999-4915
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33103
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofViruses-Basel
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectparechoviruseng
dc.subjectpicornaviruseng
dc.subjectviromeeng
dc.subjectrecombinationeng
dc.subjectcoalescenteng
dc.subjectBrazileng
dc.subject.otherpicornaviruseng
dc.subject.otherdynamicseng
dc.subject.otheridentificationeng
dc.subject.wosVirologyeng
dc.titleRecombinant Strains of Human Parechovirus in Rural Areas in the North of Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLEAL, Elcio:Univ Fed Para, Inst Ciencias Biol, BR-66075000 Belem, Para, Brazil
hcfmusp.author.externalLUCHS, Adriana:Adolfo Lutz Inst, Ctr Virol, Lab Doencas Enter, BR-01246000 Sao Paulo, Brazil
hcfmusp.author.externalKOMNINAKIS, Shirley Vasconcelos:Fac Med ABC, BR-09060870 Santo Andre, Brazil; Univ Fed Sao Paulo, Lab Retrovirol, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalLOBATO, Marcia Cristina Alves Brito Sayao:Secretaria Saude Tocantins, BR-77453000 Tocantins, Brazil; Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalBRUSTULIN, Rafael:Secretaria Saude Tocantins, BR-77453000 Tocantins, Brazil; Univ Fed Tocantins, Inst Ciencias Biol, BR-77001090 Tocantins, Brazil; Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalCHAGAS, Rogerio Togisaki das:Secretaria Saude Tocantins, BR-77453000 Tocantins, Brazil; Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalABRAO, Maria de Fatima Neves dos Santos:Secretaria Saude Tocantins, BR-77453000 Tocantins, Brazil; Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalSOARES, Cassia Vitoria de Deus Alves:Secretaria Saude Tocantins, BR-77453000 Tocantins, Brazil; Lab Cent Saude Publ Tocantins LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalVILLANOVA, Fabiola:Univ Fed Para, Inst Ciencias Biol, BR-66075000 Belem, Para, Brazil
hcfmusp.author.externalDENG, Xutao:Blood Syst Res Inst, San Francisco, CA 94143 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
hcfmusp.author.externalDELWART, Eric:Blood Syst Res Inst, San Francisco, CA 94143 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcFLAVIO AUGUSTO DE PADUA MILAGRES
hcfmusp.contributor.author-fmusphcDANIELLE ELISE GILL
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.contributor.author-fmusphcANTONIO CHARLYS DA COSTA
hcfmusp.description.issue6
hcfmusp.description.volume11
hcfmusp.origemWOS
hcfmusp.origem.pubmed31146371
hcfmusp.origem.scopus2-s2.0-85067310122
hcfmusp.origem.wosWOS:000475308000006
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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