Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANTONIO, E. Restum
dc.contributor.authorFONTES, T. M. Pereira
dc.contributor.authorSIMOES, R. S.
dc.contributor.authorCARVALHO, A. Moreira de
dc.contributor.authorESPIRIDIAO, S.
dc.contributor.authorNAKAMURA, M. Uchiyama
dc.contributor.authorKULAY JR., L.
dc.date.accessioned2013-07-30T15:32:33Z
dc.date.available2013-07-30T15:32:33Z
dc.date.issued2012
dc.description.abstractPurpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from ""day 0"" up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology.
dc.description.indexMEDLINE
dc.identifier.citationCLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, v.39, n.2, p.205-208, 2012
dc.identifier.issn0390-6663
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/1192
dc.language.isoeng
dc.publisherI R O G CANADA, INC
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecology
dc.rightsrestrictedAccess
dc.rights.holderCopyright I R O G CANADA, INC
dc.subjectRat
dc.subjectPregnancy
dc.subjectZidovudine
dc.subjectStavudine
dc.subjectAdverse effects
dc.subject.otherhiv
dc.subject.wosObstetrics & Gynecology
dc.titleEffects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalANTONIO, E. Restum:Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
hcfmusp.author.externalFONTES, T. M. Pereira:Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
hcfmusp.author.externalCARVALHO, A. Moreira de:Jose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, Brazil
hcfmusp.author.externalESPIRIDIAO, S.:ABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, Brazil
hcfmusp.author.externalNAKAMURA, M. Uchiyama:Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
hcfmusp.author.externalKULAY JR., L.:Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcRICARDO DOS SANTOS SIMOES
hcfmusp.description.beginpage205
hcfmusp.description.endpage208
hcfmusp.description.issue2
hcfmusp.description.volume39
hcfmusp.origemWOS
hcfmusp.origem.pubmed22905465
hcfmusp.origem.scopus2-s2.0-84863628237
hcfmusp.origem.wosWOS:000304899500018
hcfmusp.publisher.cityMONTREAL
hcfmusp.publisher.countryCANADA
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