Ki-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARTINS, Sandra F.
dc.contributor.authorAMORIM, Ricardo
dc.contributor.authorMOTA, Silvia Coelho
dc.contributor.authorCOSTA, Luis
dc.contributor.authorPARDAL, Fernando
dc.contributor.authorRODRIGUES, Mesquita
dc.contributor.authorLONGATTO-FILHO, Adhemar
dc.date.accessioned2015-12-10T16:56:30Z
dc.date.available2015-12-10T16:56:30Z
dc.date.issued2015
dc.description.abstractColorectal cancer is one of the most common malignancies and a leading cause of cancer death worldwide. Molecular markers may improve clinicopathologic staging and provide a basis to guide novel therapeutic strategies which target specific tumour-associated molecules according to individual tumour biology; however, so far, no ideal molecular marker has been found to predict disease progression. We tested Ki-67 proliferation marker in primary and lymph node metastasis of CRC. We observed a statistical significant difference between the positive rates of neoplastic cells positively stained by Ki-67 in both sites, with remarkable increased number of Ki-67 positive cells in primary tumor cells compared to cancer cells that invaded lymph nodes. We can speculate that the metastatic CRC in lymph node can be more resistant to the drugs that target cellular division.
dc.description.indexMEDLINE
dc.identifier.citationBIOMED RESEARCH INTERNATIONAL, article ID 131685, 13p, 2015
dc.identifier.doi10.1155/2015/131685
dc.identifier.eissn2314-6141
dc.identifier.issn2314-6133
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12573
dc.language.isoeng
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.relation.ispartofBiomed Research International
dc.rightsopenAccess
dc.rights.holderCopyright HINDAWI PUBLISHING CORPORATION
dc.subject.otherresected colorectal-carcinoma
dc.subject.otherprognostic-significance
dc.subject.othercancer-mortality
dc.subject.otherbreast-cancer
dc.subject.othercolon-cancer
dc.subject.otherimmunostaining activity
dc.subject.otherproliferation
dc.subject.otherp53
dc.subject.otheradenocarcinomas
dc.subject.otheradenomas
dc.subject.wosBiotechnology & Applied Microbiology
dc.subject.wosMedicine, Research & Experimental
dc.titleKi-67 Expression in CRC Lymph Node Metastasis Does Not Predict Survival
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryPortugal
hcfmusp.affiliation.countryisopt
hcfmusp.author.externalMARTINS, Sandra F.:Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal; ICVS 3Bs PT Govt Associate Lab, P-4710057 Braga, Portugal; Hosp Ctr Tras Os Montes & Alto Douro, Dept Surg, Unidade Hosp Chaves, P-5400279 Chaves, Portugal
hcfmusp.author.externalAMORIM, Ricardo:Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal; ICVS 3Bs PT Govt Associate Lab, P-4710057 Braga, Portugal
hcfmusp.author.externalMOTA, Silvia Coelho:Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal
hcfmusp.author.externalCOSTA, Luis:Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal
hcfmusp.author.externalPARDAL, Fernando:Braga Hosp, Dept Pathol, P-4710243 Braga, Portugal
hcfmusp.author.externalRODRIGUES, Mesquita:Braga Hosp, Coloproctol Unit, P-4710243 Braga, Portugal
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcADHEMAR LONGATTO FILHO
hcfmusp.description.articlenumber131685
hcfmusp.origemWOS
hcfmusp.origem.pubmed26448927
hcfmusp.origem.scopus2-s2.0-84942758894
hcfmusp.origem.wosWOS:000361997500001
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceLe Voyer TE, 2003, J CLIN ONCOL, V21, P2912, DOI 10.1200/JCO.2003.05.062
hcfmusp.relation.referenceSaad RS, 2004, MODERN PATHOL, V17, P197, DOI 10.1038/modpathol.3800034
hcfmusp.relation.referenceFreitas D, 2002, HEPATO-GASTROENTEROL, V49, P1269
hcfmusp.relation.referenceFerlay J, 2013, EUR J CANCER, V49, P1374, DOI 10.1016/j.ejca.2012.12.027
hcfmusp.relation.referenceMalvezzi M, 2013, ANN ONCOL, V24, P792, DOI 10.1093/annonc/mdt010
hcfmusp.relation.referenceAlexander Dominik D., 2007, Cancer Biomarkers, V3, P301
hcfmusp.relation.referenceCabibi D, 2006, ANTICANCER RES, V26, P4357
hcfmusp.relation.referenceScholzen T, 2000, J CELL PHYSIOL, V182, P311, DOI 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9
hcfmusp.relation.referencede Menezes Hunaldo Lima, 2010, Arquivos de Gastroenterologia, V47, P141, DOI 10.1590/S0004-28032010000200005
hcfmusp.relation.referenceTredan O, 2007, J NATL CANCER I, V99, P1441, DOI 10.1093/jnci/djm135
hcfmusp.relation.referenceBilchik AJ, 2006, ARCH SURG-CHICAGO, V141, P527, DOI 10.1001/archsurg.141.6.527
hcfmusp.relation.referencePinto CG, 2010, EUR J HEALTH ECON, V10, P65, DOI 10.1007/s10198-009-0187-9
hcfmusp.relation.referencePark D, 2007, VIRCHOWS ARCH, V451, P11, DOI 10.1007/s00428-007-0435-2
hcfmusp.relation.referenceGERDES J, 1983, INT J CANCER, V31, P13, DOI 10.1002/ijc.2910310104
hcfmusp.relation.referenceBrenner H, 2008, BRIT J CANCER, V99, P532, DOI 10.1038/sj.bjc.6604488
hcfmusp.relation.referenceOshima CTF, 2005, NEOPLASMA, V52, P420
hcfmusp.relation.referenceGurzu S, 2008, ROM J MORPHOL EMBRYO, V49, P149
hcfmusp.relation.referenceKUBOTA Y, 1992, CANCER, V70, P2602, DOI 10.1002/1097-0142(19921201)70:11<2602::AID-CNCR2820701106>3.0.CO;2-W
hcfmusp.relation.referenceZavoral M, 2009, WORLD J GASTROENTERO, V15, P5907, DOI 10.3748/wjg.15.5907
hcfmusp.relation.referenceCascinu S, 2003, ANN ONCOL, V14, P25, DOI 10.1093/annonc/mdg725
hcfmusp.relation.referenceMartins SF, 2013, CANCER GENOM PROTEOM, V10, P55
hcfmusp.relation.referenceEvans C, 2006, BRIT J CANCER, V94, P1412, DOI 10.1038/sj.bjc.6603104
hcfmusp.relation.referenceValera V, 2005, BRIT J SURG, V92, P1002, DOI 10.1002/bjs.4858
hcfmusp.relation.referenceBai XZ, 1999, INT J ONCOL, V14, P785
hcfmusp.relation.referenceBosetti C, 2011, INT J CANCER, V129, P180, DOI 10.1002/ijc.25653
hcfmusp.relation.referencePinheiro C, 2008, VIRCHOWS ARCH, V452, P139, DOI 10.1007/s00428-007-0558-5
hcfmusp.relation.referenceAllegra CJ, 2003, J CLIN ONCOL, V21, P241, DOI 10.1200/JCO.2003.05.044
hcfmusp.relation.referenceToru S, 2012, W INDIAN MED J, V61, P10
hcfmusp.relation.referenceBuxant F, 2002, BREAST CANCER RES TR, V75, P1, DOI 10.1023/A:1016504129183
hcfmusp.relation.referenceRies LAG, 2000, CANCER, V88, P2398, DOI 10.1002/(SICI)1097-0142(20000515)88:10<2398::AID-CNCR26>3.0.CO;2-I
hcfmusp.relation.referenceTawfik K, 2013, HUM PATHOL, V44, P39, DOI 10.1016/j.humpath.2012.05.007
hcfmusp.relation.referenceYamauchi H, 2011, INT SURG, V96, P352
hcfmusp.relation.referenceDes Guetz G, 2006, BRIT J CANCER, V94, P1823, DOI 10.1038/sj.bjc.6603176
hcfmusp.relation.referenceDziegiel P, 2003, HISTOL HISTOPATHOL, V18, P401
hcfmusp.relation.referenceJansson A, 1997, APMIS, V105, P730
hcfmusp.relation.referenceBarozzi C, 2002, CANCER, V94, P647, DOI 10.1002/cncr.10278
hcfmusp.relation.referenceBROWN DC, 1990, HISTOPATHOLOGY, V17, P489, DOI 10.1111/j.1365-2559.1990.tb00788.x
hcfmusp.relation.referenceCalvo H. J., 2000, CIR ESPAN, V68, P577
hcfmusp.relation.referenceGao W. X., 2007, XIAN DAI YU FANG YI, V2, P225
hcfmusp.relation.referenceGhita C, 2012, ROM J MORPHOL EMBRYO, V53, P549
hcfmusp.relation.referenceGreene FL, 2002, AJCC CANC STAGING MA
hcfmusp.relation.referenceGuzinska-Ustymowicz K, 2008, ANTICANCER RES, V28, P451
hcfmusp.relation.referenceHarvey J, 2015, PATHOLOGY, V47, P13, DOI 10.1097/PAT.0000000000000192
hcfmusp.relation.referenceHashimoto Y, 2006, BMC CANCER, V6, DOI 10.1186/1471-2407-6-241
hcfmusp.relation.referenceHosaka M., 1998, PATHOLOGY INT, V48, P41
hcfmusp.relation.referenceJo M. J., 2015, WORLD J GASTROENTERO, V21, P667
hcfmusp.relation.referenceLin Miao-Xia, 2008, Ai Zheng, V27, P1321
hcfmusp.relation.referenceLongo D. L., 2012, HARRISONS PRINCIPLES
hcfmusp.relation.referenceMartins SF, 2011, WJC, V10, P272
hcfmusp.relation.referenceMicev M, 2004, Acta Chir Iugosl, V51, P99
hcfmusp.relation.referenceNabi Uzma, 2008, J Ayub Med Coll Abbottabad, V20, P44
hcfmusp.relation.referenceNussrat Faris Lutfi, 2011, Oman Med J, V26, P229, DOI 10.5001/omj.2011.57
hcfmusp.relation.referenceSaleh H A, 1999, Pathol Oncol Res, V5, P273, DOI 10.1053/paor.1999.0231
hcfmusp.relation.referenceSvagzdys S, 2009, BMC CANCER, V9, DOI 10.1186/1471-2407-9-95
hcfmusp.relation.referenceZafar SY, 2008, BMC CANCER, V8, DOI 10.1186/1471-2407-8-345
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