International prescribing practices in obsessive-compulsive disorder (OCD)

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBRAKOULIAS, Vlasios
dc.contributor.authorSTARCEVIC, Vladan
dc.contributor.authorBELLOCH, Amparo
dc.contributor.authorDELL'OSSO, Liliana
dc.contributor.authorFERRAO, Ygor A.
dc.contributor.authorFONTENELLE, Leonardo F.
dc.contributor.authorLOCHNER, Christine
dc.contributor.authorMARAZZITI, Donatella
dc.contributor.authorMARTIN, Andrew
dc.contributor.authorMATSUNAGA, Hisato
dc.contributor.authorMIGUEL, Euripedes C.
dc.contributor.authorREDDY, Y. C. Janardhan
dc.contributor.authorROSARIO, Maria C. do
dc.contributor.authorSHAVITT, Roseli G.
dc.contributor.authorSUNDAR, Arumugham Shyam
dc.contributor.authorSTEIN, Dan Joseph
dc.contributor.authorVISWASAM, Kirupamani
dc.date.accessioned2016-10-17T16:41:03Z
dc.date.available2016-10-17T16:41:03Z
dc.date.issued2016
dc.description.abstractObjectivesTo assess rates of psychotropic medication use in patients with obsessive-compulsive disorder (OCD) in seven different countries on five continents and to compare these with international treatment guidelines. MethodsResearchers in the field of OCD were invited to contribute summary statistics on the characteristics of their patients with OCD and on their incidence of psychotropic use. Consistency of summary statistics across countries was evaluated. ResultsThe data came from Brazil (n=955), Italy (n=750), South Africa (n=555), Japan (n=382), Australia (n=213), India (n=202) and Spain (n=82). The majority (77.9%; n=2445) of the total sample of 3139 participants received a psychotropic medication. Consistent with international guidelines, selective serotonin reuptake inhibitors (SSRIs) were most commonly used (73.5%, n=1796), but their use ranged from 59% in Australia to 96% in Japan. Clomipramine use varied from 5% in Japan and South Africa to 26% in India and Italy. Atypical antipsychotic use ranged from 12% in South Africa to 50% in Japan. ConclusionsPharmacotherapy for OCD varied significantly across sites. Prospective studies are required to determine the cultural, pharmacoeconomic and pharmacogenomic factors that may play a role in the variation in prescribing practices internationally and whether these variations influence treatment outcomes.
dc.description.indexMEDLINE
dc.description.sponsorshipNepean Medical Research Foundation
dc.description.sponsorshipPfizer Neuroscience Grant Programme
dc.description.sponsorshipSpanish MINECO [PSI2013-44733-R]
dc.description.sponsorshipUniversity of Sydney
dc.identifier.citationHUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, v.31, n.4, p.319-324, 2016
dc.identifier.doi10.1002/hup.2541
dc.identifier.eissn1099-1077
dc.identifier.issn0885-6222
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16310
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofHuman Psychopharmacology-Clinical and Experimental
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectcross-cultural study
dc.subjectobsessive-compulsive disorder
dc.subjectpharmacotherapy
dc.subjectmedication
dc.subjectselective serotonin re-uptake inhibitors
dc.subjectantipsychotics
dc.subjectbenzodiazepines
dc.subject.otherposttraumatic-stress-disorder
dc.subject.otherpharmacological-treatment
dc.subject.otheranxiety disorders
dc.subject.otherguidelines
dc.subject.otherbenzodiazepines
dc.subject.otherrevision
dc.subject.othersymptoms
dc.subject.otheraccess
dc.subject.otherbrazil
dc.subject.otheronset
dc.subject.wosClinical Neurology
dc.subject.wosPharmacology & Pharmacy
dc.subject.wosPsychiatry
dc.subject.wosPsychology
dc.titleInternational prescribing practices in obsessive-compulsive disorder (OCD)
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryEspanha
hcfmusp.affiliation.countryÍndia
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryJapão
hcfmusp.affiliation.countryÁfrica do Sul
hcfmusp.affiliation.countryisoau
hcfmusp.affiliation.countryisoes
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisoza
hcfmusp.affiliation.countryisojp
hcfmusp.affiliation.countryisoin
hcfmusp.author.externalBRAKOULIAS, Vlasios:Univ Sydney, Dept Psychiat, Sydney, NSW, Australia; Nepean Hosp, Sydney Med Sch Nepean, Discipline Psychiat, Penrith, NSW, Australia
hcfmusp.author.externalSTARCEVIC, Vladan:Univ Sydney, Dept Psychiat, Sydney, NSW, Australia; Nepean Hosp, Sydney Med Sch Nepean, Discipline Psychiat, Penrith, NSW, Australia
hcfmusp.author.externalBELLOCH, Amparo:Univ Valencia, Fac Psychol, Res Unit Obsessive Compuls & Related Disorders, Dept Personal Psychol,ITOC, E-46003 Valencia, Spain
hcfmusp.author.externalDELL'OSSO, Liliana:Univ Pisa, Dipartmento Farm, Sect Psychiat, Dipartimento Med Clin & Sperimentale, I-56100 Pisa, Italy
hcfmusp.author.externalFERRAO, Ygor A.:Fed Univ Hlth Sci Porto Alegre, Dept Psychiat, Porto Alegre, RS, Brazil
hcfmusp.author.externalFONTENELLE, Leonardo F.:Univ Fed Rio de Janeiro, Dept Psychiat & Legal Med, BR-21941 Rio De Janeiro, Brazil; Monash Univ, Monash Inst Cognit & Clin Neurosci, DOr Inst Res & Educ, Clayton, Vic 3800, Australia
hcfmusp.author.externalLOCHNER, Christine:Univ Stellenbosch, Dept Psychiat, MRC Unit Anxiety Disorders, Cape Town, South Africa
hcfmusp.author.externalMARAZZITI, Donatella:Univ Pisa, Dipartmento Farm, Sect Psychiat, Dipartimento Med Clin & Sperimentale, I-56100 Pisa, Italy
hcfmusp.author.externalMARTIN, Andrew:Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW, Australia
hcfmusp.author.externalMATSUNAGA, Hisato:Hyogo Coll Med, Dept Neuropsychiat, Nishinomiya, Hyogo, Japan
hcfmusp.author.externalREDDY, Y. C. Janardhan:Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat, Bengaluru, India
hcfmusp.author.externalROSARIO, Maria C. do:Univ Fed Sao Paulo, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo, Brazil
hcfmusp.author.externalSUNDAR, Arumugham Shyam:Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Psychiat, Bengaluru, India
hcfmusp.author.externalSTEIN, Dan Joseph:Univ Stellenbosch, Dept Psychiat, MRC Unit Anxiety Disorders, Cape Town, South Africa
hcfmusp.author.externalVISWASAM, Kirupamani:Univ Sydney, Dept Psychiat, Sydney, NSW, Australia; Nepean Hosp, Sydney Med Sch Nepean, Discipline Psychiat, Penrith, NSW, Australia
hcfmusp.citation.scopus22
hcfmusp.contributor.author-fmusphcEURIPEDES CONSTANTINO MIGUEL FILHO
hcfmusp.contributor.author-fmusphcROSELI GEDANKE SHAVITT
hcfmusp.description.beginpage319
hcfmusp.description.endpage324
hcfmusp.description.issue4
hcfmusp.description.volume31
hcfmusp.origemWOS
hcfmusp.origem.pubmed27271200
hcfmusp.origem.scopus2-s2.0-84977641360
hcfmusp.origem.wosWOS:000379939200007
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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