High p16(INK4a) immunoexpression is not HPV dependent in oral leukoplakia

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOMO, Saygo
dc.contributor.authorBISS, Stephanye Pinto
dc.contributor.authorCRIVELINI, Marcelo Macedo
dc.contributor.authorOLIVEIRA, Sandra Helena Penha de
dc.contributor.authorBIASOLI, Eder Ricardo
dc.contributor.authorTJIOE, Kellen Cristine
dc.contributor.authorBERNABE, Daniel Galera
dc.contributor.authorVILLA, Luisa Lina
dc.contributor.authorMIYAHARA, Glauco Issamu
dc.date.accessioned2020-08-20T13:20:40Z
dc.date.available2020-08-20T13:20:40Z
dc.date.issued2020
dc.description.abstractObjective: To evaluate the prevalence of HPV DNA detection in fresh tissue from oral leukoplakia by Linear Array assay, and its correlation with p16(INK4a) immunoexpression in the northwest region of the Sao Paulo state, Brazil. Patients and methods: Fifty patients diagnosed with oral leukoplakia were included in the study. Sociodemographic, clinicopathologic and lifestyle data, fresh tissue and formalin fixed paraffin embedded (FFPE) tissue samples were collected. The fresh tissue was stored at -80 degrees C and then submitted to further viral DNA detection by the Linear Array method. Immunohistochemical analysis for the p16(INK4a) expression was performed. Results: Of the 50 patients included in the study, 62 % were men, and the age ranged from 25 to 82 years. Twenty-three (46 %) were elderly, 46 % were middle-aged adults, and only 12 % were young adults. Most patients were smokers (76 %), 14 % were former smokers, and 10 % were non-smokers. Most patients (56 %) were current drinkers, 22 % were ex-drinkers and 22 % were non-drinkers. Thirty-two percent of the lesions presented some degree of dysplasia. No lesions were positive to HPV by Linear Array detection. Thirty (60 %) OL had p16-low immunoexpression and 20 (40 %) had p16-high immunoexpression. Conclusion: HPV was not identified in the population studied. The high p16(INK4a) immunoexpression is not dependent on HPV in oral leukoplakia. Broader epidemiological studies are required to clarify the geographic variability in the prevalence of HPV in head and neck squamous cell carcinoma and oral potentially malignant lesions.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/12982-0]
dc.description.sponsorship[88882.435595/2019-01]
dc.identifier.citationARCHIVES OF ORAL BIOLOGY, v.115, article ID 104738, 7p, 2020
dc.identifier.doi10.1016/j.archoralbio.2020.104738
dc.identifier.eissn1879-1506
dc.identifier.issn0003-9969
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36802
dc.language.isoeng
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDeng
dc.relation.ispartofArchives of Oral Biology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright PERGAMON-ELSEVIER SCIENCE LTDeng
dc.subjectOral leukoplakiaeng
dc.subjectHuman papillomaviruseng
dc.subjectPolymerase chain reactioneng
dc.subjectp16(INK4A)eng
dc.subject.otherhuman-papillomavirus infectioneng
dc.subject.otherpotentially malignant disorderseng
dc.subject.othersquamous-cell carcinomaeng
dc.subject.otherprevalenceeng
dc.subject.otherviruseng
dc.subject.otherlesionseng
dc.subject.otherheadeng
dc.subject.otherdnaeng
dc.subject.otherexpressioneng
dc.subject.othersmokingeng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.titleHigh p16(INK4a) immunoexpression is not HPV dependent in oral leukoplakiaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTOMO, Saygo:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil; Sao Paulo State Univ UNESP, Sch Dent, Dept Diag & Surg, Aracatuba, Brazil
hcfmusp.author.externalBISS, Stephanye Pinto:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil
hcfmusp.author.externalCRIVELINI, Marcelo Macedo:Sao Paulo State Univ UNESP, Sch Dent, Dept Diag & Surg, Aracatuba, Brazil
hcfmusp.author.externalOLIVEIRA, Sandra Helena Penha de:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil; Sao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Lab Pharmacol, Aracatuba, SP, Brazil
hcfmusp.author.externalBIASOLI, Eder Ricardo:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil; Sao Paulo State Univ UNESP, Sch Dent, Dept Diag & Surg, Aracatuba, Brazil
hcfmusp.author.externalTJIOE, Kellen Cristine:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil; Sao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Lab Pharmacol, Aracatuba, SP, Brazil
hcfmusp.author.externalBERNABE, Daniel Galera:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil; Sao Paulo State Univ UNESP, Sch Dent, Dept Diag & Surg, Aracatuba, Brazil
hcfmusp.author.externalMIYAHARA, Glauco Issamu:Sao Paulo State Univ UNESP, Oral Oncol Ctr, Sch Dent, Jose Bonifacio St 1193, BR-16015050 Aracatuba, SP, Brazil; Sao Paulo State Univ UNESP, Sch Dent, Dept Diag & Surg, Aracatuba, Brazil
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcLUISA LINA VILLA
hcfmusp.description.articlenumber104738
hcfmusp.description.volume115
hcfmusp.origemWOS
hcfmusp.origem.pubmed32413587
hcfmusp.origem.scopus2-s2.0-85084513438
hcfmusp.origem.wosWOS:000537622400008
hcfmusp.publisher.cityOXFORDeng
hcfmusp.publisher.countryENGLANDeng
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