Frailty as a Predictor of Cognitive Disorders: A Systematic Review and Meta-Analysis
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Citações na Scopus
116
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
Citação
FRONTIERS IN MEDICINE, v.6, article ID 26, 8p, 2019
Resumo
Background/Aim: Current evidence in the literature supports associations between frailty, cognitive impairment, and dementia. The study aim was to describe the risk of cognitive disorders associated with physical frailty in older adults from community-based studies. Methods: We performed a systematic review and meta-analysis, using MEDLINE, PsycINFO, Scopus, and Web of Science as databases for the search. Cohort and longitudinal studies were included in qualitative analysis and quantitative synthesis. For inclusion, studies had to assess dementia and cognitive impairment as a primary or secondary outcome, and describe the prevalence of frailty among participants at baseline and follow-up. Results: Of the 2,210 studies retrieved by the systematic review, 6 relevant studies were included in ameta-analysis. Baseline frailty was significantly associated with an increased risk of geriatric cognitive disorders (pooled OR = 1.80, 95% CI = 1.11-2.92; p = 0.02). Heterogeneity across the studies was significant (I-2 = 79%). Conclusions: The analyses confirmed that frail older adults were at higher risk of incident cognitive disorders than non-frail elders. Frailty status seems to be most associated with the risk of incident dementia. Frailty may represent a risk factor for dementia and could constitute a novel modifiable target in early cognitive impairment.
Palavras-chave
mild cognitive impairment, cognitive decline, dementia, cognitive disorders, comorbidity, elderly, meta-analysis
Referências
- Avila-Funes JA, 2012, J AM GERIATR SOC, V60, P1708, DOI 10.1111/j.1532-5415.2012.04142.x
- American Psychiatry Association, 2013, DIAGNOSTIC STAT MANU
- Assar Mariam El, 2019, Curr Opin Clin Nutr Metab Care, V22, P52, DOI 10.1097/MCO.0000000000000535
- Assuncao N, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0194990
- Boyle PA, 2010, J AM GERIATR SOC, V58, P248, DOI 10.1111/j.1532-5415.2009.02671.x
- Buchman AS, 2007, PSYCHOSOM MED, V69, P483, DOI 10.1097/psy.0b013e318068e1d
- Buchman AS, 2014, J GERONTOL A-BIOL, V69, P1536, DOI 10.1093/gerona/glu117
- Canevelli M, 2017, J AM MED DIR ASSOC, V18, P816, DOI 10.1016/j.jamda.2017.07.004
- Canevelli M, 2017, FRONT AGING NEUROSCI, V9, DOI 10.3389/fnagi.2017.00036
- Clegg A, 2013, LANCET, V381, P752, DOI 10.1016/S0140-6736(12)62167-9
- Collard RM, 2012, J AM GERIATR SOC, V60, P1487, DOI 10.1111/j.1532-5415.2012.04054.x
- Eden J, 2011, COMMITTEE STANDARDS
- Feng L, 2017, J GERONTOL A-BIOL, V72, P369, DOI 10.1093/gerona/glw050
- Fried LP, 2001, J GERONTOL A-BIOL, V56, pM146, DOI 10.1093/gerona/56.3.M146
- Gill TM, 2010, NEW ENGL J MED, V362, P1173, DOI 10.1056/NEJMoa0909087
- Gobbens RJ, 2012, J ADV NURS, V68, P2047, DOI 10.1111/j.1365-2648.2011.05896.x
- Gobbens RJJ, 2010, J AM MED DIR ASSOC, V11, P338, DOI 10.1016/j.jamda.2009.09.015
- Gorelick PB, 2011, STROKE, V42, P2672, DOI 10.1161/STR.0b013e3182299496
- Gray SL, 2013, J GERONTOL A-BIOL, V68, P1083, DOI 10.1093/gerona/glt013
- Kojima G, 2017, CURR ALZHEIMER RES, V14, P1256, DOI 10.2174/1567205014666170417104236
- Kojima G, 2016, J AM MED DIR ASSOC, V17, P881, DOI 10.1016/j.jamda.2016.05.013
- Leritz EC, 2011, CURR CARDIOVASC RISK, V5, P407, DOI 10.1007/s12170-011-0189-x
- McGough E. L., 2013, Annals of Physical and Rehabilitation Medicine, V56, P329, DOI 10.1016/j.rehab.2013.02.005
- MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
- Moher D, 2009, J CLIN EPIDEMIOL, V62, P1006, DOI 10.1016/j.jclinepi.2009.06.005
- Montero-Odasso MM, 2016, J GERONTOL A-BIOL, V71, P1476, DOI 10.1093/gerona/glw044
- Morley JE, 2015, J AM MED DIR ASSOC, V16, P731, DOI 10.1016/j.jamda.2015.06.017
- Mulero J, 2011, J NUTR HEALTH AGING, V15, P756, DOI 10.1007/s12603-011-0130-5
- Panza F, 2011, J NUTR HEALTH AGING, V15, P711, DOI 10.1007/s12603-011-0126-1
- Panza F, 2018, J ALZHEIMERS DIS, V62, P993, DOI 10.3233/JAD-170963
- Panza F, 2017, EXPERT OPIN DRUG MET, V13, P1023, DOI 10.1080/17425255.2017.1372424
- Panza F, 2015, J ALZHEIMERS DIS, V47, P793, DOI 10.3233/JAD-150358
- Panza F, 2015, REJUV RES, V18, P389, DOI 10.1089/rej.2014.1637
- Perez-Tasigchana RF, 2017, AGE AGEING, V46, P807, DOI 10.1093/ageing/afx023
- Robertson DA, 2013, AGEING RES REV, V12, P840, DOI 10.1016/j.arr.2013.06.004
- Rockwood K, 2007, J GERONTOL A-BIOL, V62, P722, DOI 10.1093/gerona/62.7.722
- ROMAN GC, 1993, NEUROLOGY, V43, P250, DOI 10.1212/WNL.43.2.250
- Ruan QW, 2015, AGEING RES REV, V20, P1, DOI 10.1016/j.arr.2014.12.004
- Sargent L, 2017, J NUTR HEALTH AGING, V21, P152, DOI 10.1007/s12603-016-0735-9
- Searle SD, 2015, ALZHEIMERS RES THER, V7, DOI 10.1186/s13195-015-0140-3
- Solfrizzi V, 2017, J AM MED DIR ASSOC, V18, DOI 10.1016/j.jamda.2016.10.012
- Solfrizzi V, 2013, ALZHEIMERS DEMENT, V9, P113, DOI 10.1016/j.jalz.2011.09.223
- Song XW, 2014, ALZHEIMERS RES THER, V6, DOI 10.1186/s13195-014-0054-5
- Starr KNP, 2014, J AM MED DIR ASSOC, V15, P240, DOI 10.1016/j.jamda.2013.11.008
- Veronese N, 2017, AGEING RES REV, V35, P63, DOI 10.1016/j.arr.2017.01.003
- Vetrano DL, 2018, BMJ OPEN, V8, DOI 10.1136/bmjopen-2018-024406
- Villani ER, 2018, EUR J INTERN MED, V56, P33, DOI 10.1016/j.ejim.2018.04.018
- Wells G, NEWCASTLE OTTAWA SCA
- Wilkins CH, 2013, J AM GERIATR SOC, V61, P1055, DOI 10.1111/jgs.12255
- Xu W, 2015, J NEUROL NEUROSUR PS, V86, P1299, DOI 10.1136/jnnp-2015-310548
- Zlokovic BV, 2011, NAT REV NEUROSCI, V12, P723, DOI 10.1038/nrn3114