Expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 genes in eutopic endometrium of infertile women with endometriosis during the implantation window: A pilot study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBROI, M. G. Da
dc.contributor.authorROCHA JUNIOR, C. V.
dc.contributor.authorMEOLA, J.
dc.contributor.authorMARTINS, W. P.
dc.contributor.authorCARVALHO, F. M.
dc.contributor.authorFERRIANI, R. A.
dc.contributor.authorNAVARRO, P. A.
dc.date.accessioned2018-02-16T13:40:26Z
dc.date.available2018-02-16T13:40:26Z
dc.date.issued2017
dc.description.abstractObjective: Alterations in endometrial receptivity may be involved in the etiopathogenesis of endometriosis-related infertility. The literature has suggested that patients with endometriosis present progestin resistance, which could affect embryo implantation. We question the presence of alterations in the expression of the progesterone receptor gene (PGR) and the genes related to endometrium embryo interaction regulated by progesterone. This pilot study compared the expression of PGR, HBEGF, ITGAV, ITGB3, and SPP1 genes in eutopic endometrium during the implantation window (IW) in infertile women with endometriosis with that observed in the endometrium of fertile and infertile controls. Methods: In this prospective case-control study, endometrial biopsies were performed during the IW in patients aged between 18 and 45 years old, with regular cycles and without endocrine/systemic dysfunctions, divided into endometriosis (END), infertile control (IC) and fertile control (FC) groups. Total RNA extraction, cDNA synthesis, and gene expression analysis by Real-Time PCR were performed. We assessed the size of the difference that our series was powered to detect. Results: From the 687 patients who underwent diagnostic videolaparoscopy or tubal ligation at the University Hospital, 130 were eligible. Of these, 32 had endometrial samples collected, with 17 confirmed in the IW. Fifteen samples (5 END, 5 IC and 5 FC) were analyzed. There was no significant difference in the expression of any studied gene. Our sample size allowed us to identify or discard large differences (two standard deviations) among the groups. Conclusion: Endometriosis doesn’t cause large changes in the endometrial expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 during the IW. © 2017, Sociedade Brasileira de Reproducao Assistida. All rights reserved.
dc.description.indexMEDLINE
dc.description.sponsorship2011/17614-6, Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.description.sponsorship471943/2012-6, Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorship140137/2015-7, Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipPA Research Foundation
dc.identifier.citationJORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA, v.21, n.3, p.196-202, 2017
dc.identifier.doi10.5935/1518-0557.20170038
dc.identifier.issn1517-5693
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/25020
dc.language.isoeng
dc.publisherSOCIEDADE BRASILEIRA DE REPRODUCAO ASSISTIDA
dc.relation.ispartofJornal Brasileiro de Reproducao Assistida
dc.rightsrestrictedAccess
dc.rights.holderCopyright SOCIEDADE BRASILEIRA DE REPRODUCAO ASSISTIDA
dc.subjectEmbryo implantation
dc.subjectEndometriosis
dc.subjectEndometrium
dc.subjectInfertility
dc.subject.otherosteopontin
dc.subject.otheradult
dc.subject.otherarticle
dc.subject.otherbody mass
dc.subject.othercase control study
dc.subject.othercontrolled study
dc.subject.otherendometriosis
dc.subject.otherendometrium biopsy
dc.subject.otherfemale
dc.subject.othergene
dc.subject.othergene expression
dc.subject.otherhbegf gene
dc.subject.otherhistology
dc.subject.otherhuman
dc.subject.otherhuman tissue
dc.subject.otherinfertility
dc.subject.otheritgav gene
dc.subject.otheritgb3 gene
dc.subject.otherlaparoscopy
dc.subject.othermajor clinical study
dc.subject.othermenstrual cycle
dc.subject.otherpgr gene
dc.subject.otherpilot study
dc.subject.otherprospective study
dc.subject.otherreal time polymerase chain reaction
dc.subject.otherrna extraction
dc.subject.otherspp1 gene
dc.titleExpression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 genes in eutopic endometrium of infertile women with endometriosis during the implantation window: A pilot study
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBROI, M. G. Da:Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalROCHA JUNIOR, C. V.:Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalMEOLA, J.:Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalMARTINS, W. P.:Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalFERRIANI, R. A.:Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalNAVARRO, P. A.:Human Reproduction Division, Department of Obstetrics and Gynecology, Ribeirao Preto School of Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil, National Institute of Hormones and Woman’s Health, CNPq, Brazil
hcfmusp.citation.scopus14
hcfmusp.contributor.author-fmusphcFILOMENA MARINO CARVALHO
hcfmusp.description.beginpage196
hcfmusp.description.endpage202
hcfmusp.description.issue3
hcfmusp.description.volume21
hcfmusp.origemSCOPUS
hcfmusp.origem.pubmed28837027
hcfmusp.origem.scopus2-s2.0-85029127323
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