The Symbiotic Effect of a New Nutraceutical with Yeast beta-Glucan, Prebiotics, Minerals, and Silybum marianum (Silymarin) for Recovering Metabolic Homeostasis via Pgc-1 alpha, Il-6, and Il-10 Gene Expression in a Type-2 Diabetes Obesity Model

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Arquivos
art_SANTAMARINA_The_Symbiotic_Effect_of_a_New_Nutraceutical_with_2022.PDF (6.07 MB)
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2022
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
SANTAMARINA, Aline Boveto
NEHMI FILHO, Victor
MIRANDA, Danielle Araujo de
CERQUEIRA, Anderson Romerio Azevedo
COSTA, Soraia Katia Pereira
FERREIRA, Ana Flavia Fernandes
BRITTO, Luiz Roberto
Citação
ANTIOXIDANTS, v.11, n.3, article ID 447, 24p, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The use of natural products and derivatives for the prevention and control of non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, and hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into the following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, HFD + Supplemented_S, and isolated compounds. The vehicle and experimental formulations were administered orally by gavage once a day over the four weeks of the diet (28 consecutive days). We evaluated the energy homeostasis, cytokines, and mitochondrial gene expression in these groups of mice. After four weeks of supplementation, only the new nutraceutical group (HFD + Supplemented) experienced reduced fasting glycemia, insulin, HOMA index, HOMA-beta, dyslipidemia, ectopic fat deposition, and hepatic fibrosis levels. Additionally, the PPAR gamma coactivator 1 alpha (Pgc-1 alpha), interleukin-6 (Il-6), and interleukin-10 (Il-10) gene expression were augmented, while hepatic steatosis decreased and liver parenchyma was recovered. The glutathione-S-transferase activity status was found to be modulated by the supplement. We discovered that the new nutraceutical was able to improve insulin resistance and hepatic steatosis mainly by regulating IL 6, IL 10, and Pgc-1 alpha. gene expression.
Palavras-chave
nutraceutical, silymarin, prebiotic, yeast beta-glucan, minerals, obesity, type-2 diabetes, Interleukin-6, Pgc-1 alpha, antioxidant enzymes
URI
https://observatorio.fm.usp.br/handle/OPI/46993
Referências
  1. Abenavoli L, 2018, PHYTOTHER RES, V32, P2202, DOI 10.1002/ptr.6171
  2. Abou Seif H.S., 2016, BENI SUEF U J BASIC, V5, P134, DOI [10.1016/j.bjbas.2016.03.004, DOI 10.1016/J.BJBAS.2016.03.004]
  3. Akbari M, 2018, INFLAMMOPHARMACOLOGY, V26, P685, DOI 10.1007/s10787-018-0458-0
  4. Al-Goblan AS, 2014, DIABETES METAB SYNDR, V7, P587, DOI 10.2147/DMSO.S67400
  5. Andrade EF, 2016, NUTRIENTS, V8, DOI 10.3390/nu8120792
  6. [Anonymous], 2017, EFSA SUPPORT PUBL, V14, pe15121, DOI [10.2903/sp.efsa.2017.e15121, DOI 10.2903/SP.EFSA.2017.E15121]
  7. ARQUILLA ER, 1978, ENDOCRINOLOGY, V103, P1440, DOI 10.1210/endo-103-4-1440
  8. Awazawa M, 2011, CELL METAB, V13, P401, DOI 10.1016/j.cmet.2011.02.010
  9. Barry JC, 2016, SCI REP-UK, V6, DOI 10.1038/srep21244
  10. Berger J, 2002, ANNU REV MED, V53, P409, DOI 10.1146/annurev.med.53.082901.104018
  11. Besse-Patin A, 2019, P NATL ACAD SCI USA, V116, P4285, DOI 10.1073/pnas.1815150116
  12. Shoelson SE, 2006, J CLIN INVEST, V116, P1793, DOI 10.1172/JCI29069
  13. Silva VD, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091016
  14. Steensberg A, 2003, AM J PHYSIOL-ENDOC M, V285, pE433, DOI 10.1152/ajpendo.00074.2003
  15. Tanaka T, 2014, CSH PERSPECT BIOL, V6, DOI 10.1101/cshperspect.a016295
  16. Torres DPM, 2010, COMPR REV FOOD SCI F, V9, P438, DOI 10.1111/j.1541-4337.2010.00119.x
  17. Vairetti M, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030364
  18. Valsesia A, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-65936-8
  19. Wan XY, 2020, FASEB J, V34, P10751, DOI 10.1096/fj.201902476R
  20. Whitehead JP, 2006, DIABETES OBES METAB, V8, P264, DOI 10.1111/j.1463-1326.2005.00510.x
  21. Winzell MS, 2004, DIABETES, V53, pS215, DOI 10.2337/diabetes.53.suppl_3.S215
  22. Woods SC, 2003, J NUTR, V133, P1081, DOI 10.1093/jn/133.4.1081
  23. Xu E, 2017, NAT COMMUN, V8, DOI 10.1038/ncomms14803
  24. Xu LM, 2020, J INTEGR MED-JIM, V18, P203, DOI 10.1016/j.joim.2020.03.001
  25. Ye JP, 2013, FRONT MED-PRC, V7, P14, DOI 10.1007/s11684-013-0262-6
  26. Zhang YQ, 2004, GENE DEV, V18, P157, DOI 10.1101/gad.1138104
  27. Zhu D, 2019, NUTRIENTS, V11, DOI 10.3390/nu11081705
  28. Besse-Patin A, 2017, GASTROENTEROLOGY, V152, P243, DOI 10.1053/j.gastro.2016.09.017
  29. Byrne CD, 2013, P NUTR SOC, V72, P412, DOI 10.1017/S0029665113001249
  30. Canfora EE, 2017, GASTROENTEROLOGY, V153, P87, DOI 10.1053/j.gastro.2017.03.051
  31. Cani PD, 2011, PHARMACOL THERAPEUT, V130, P202, DOI 10.1016/j.pharmthera.2011.01.012
  32. Cao Y, 2016, MOL NUTR FOOD RES, V60, P2678, DOI 10.1002/mnfr.201600032
  33. Cena H, 2020, NUTRIENTS, V12, DOI 10.3390/nu12020334
  34. Charlton MR, 2011, GASTROENTEROLOGY, V141, P1249, DOI 10.1053/j.gastro.2011.06.061
  35. Chen LX, 2016, INT IMMUNOPHARMACOL, V37, P65, DOI 10.1016/j.intimp.2016.02.005
  36. Costa GT, 2012, ACTA CIR BRAS, V27, P279, DOI 10.1590/S0102-86502012000300013
  37. Couto N, 2016, FREE RADICAL BIO MED, V95, P27, DOI 10.1016/j.freeradbiomed.2016.02.028
  38. Darnton-Hill I, 2004, PUBLIC HEALTH NUTR, V7, P101, DOI 10.1079/PHN2003584
  39. Dastidar SG, 2018, AM J PHYSIOL-ENDOC M, V315, pE1005, DOI 10.1152/ajpendo.00345.2017
  40. De Vadder F, 2014, CELL, V156, P84, DOI 10.1016/j.cell.2013.12.016
  41. Delarue J, 2007, CURR OPIN CLIN NUTR, V10, P142, DOI 10.1097/MCO.0b013e328042ba90
  42. Dixon JB, 2003, DIABETIC MED, V20, P127, DOI 10.1046/j.1464-5491.2003.00889.x
  43. Erickson SK, 2009, J LIPID RES, V50, pS412, DOI 10.1194/jlr.R800089-JLR200
  44. Evans JL, 2002, ENDOCR REV, V23, P599, DOI 10.1210/er.2001-0039
  45. Fernandes R, 2016, J CLIN GASTROENTEROL, V50, P208, DOI 10.1097/MCG.0000000000000328
  46. Fischer Andrew H, 2008, CSH Protoc, V2008, DOI 10.1101/pdb.prot4986
  47. Fontenelle LC, 2018, BRAZ J PHARM SCI, V54, DOI 10.1590/s2175-97902018000100139
  48. Lima LCF, 2015, FRONT PHYSIOL, V6, DOI 10.3389/fphys.2015.00304
  49. FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499
  50. Gao MM, 2013, MOL THER, V21, P1852, DOI 10.1038/mt.2013.125
  51. Gregor MF, 2011, ANNU REV IMMUNOL, V29, P415, DOI 10.1146/annurev-immunol-031210-101322
  52. Hardwick RN, 2010, DRUG METAB DISPOS, V38, P2293, DOI 10.1124/dmd.110.035006
  53. Hashmi A, 2016, PROBIOTICS ANTIMICRO, V8, P19, DOI 10.1007/s12602-016-9206-1
  54. Hayes JD, 2005, ANNU REV PHARMACOL, V45, P51, DOI 10.1146/annurev.pharmtox.45.120403.095857
  55. Hedges L.V., 1981, J EDUC STAT, V6, P107, DOI [10.3102/10769986006002107, DOI 10.3102/10769986006002107]
  56. Henriksen EJ, 2011, FREE RADICAL BIO MED, V51, P993, DOI 10.1016/j.freeradbiomed.2010.12.005
  57. Hernandez AH, 2015, INT J CLIN EXP PATHO, V8, P3946
  58. Hoehn KL, 2009, P NATL ACAD SCI USA, V106, P17787, DOI 10.1073/pnas.0902380106
  59. Hotamisligil GS, 2006, NATURE, V444, P860, DOI 10.1038/nature05485
  60. Iossa S, 2003, BRIT J NUTR, V90, P953, DOI 10.1079/BJN2003000968
  61. Kawaguchi K, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000026835
  62. Kern L, 2019, CANCERS, V11, DOI 10.3390/cancers11010024
  63. Kim HJ, 2004, DIABETES, V53, P1060, DOI 10.2337/diabetes.53.4.1060
  64. Kim JH, 2009, VITAM HORM, V80, P613, DOI 10.1016/S0083-6729(08)00621-3
  65. Kim J, 2014, BIOL TRACE ELEM RES, V157, P101, DOI 10.1007/s12011-013-9885-3
  66. Klover PJ, 2005, ENDOCRINOLOGY, V146, P3417, DOI 10.1210/en.2004-1468
  67. Kobayashi M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22116025
  68. Konstantinidi Melina, 2019, Medicines (Basel), V6, DOI 10.3390/medicines6030094
  69. Koo SH, 2004, NAT MED, V10, P530, DOI 10.1038/nm1044
  70. Lean MEJ, 2018, LANCET, V391, P541, DOI 10.1016/S0140-6736(17)33102-1
  71. Leigh SJ, 2020, TRANSL PSYCHIAT, V10, DOI 10.1038/s41398-020-0734-9
  72. Liu C, 2007, NATURE, V447, P477, DOI 10.1038/nature05767
  73. Liu FT, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-10722-2
  74. Livak KJ, 2001, METHODS, V25, P402, DOI 10.1006/meth.2001.1262
  75. Lobato RV, 2015, NUTR HOSP, V32, P256, DOI 10.3305/nh.2015.32.1.9013
  76. Longo M, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20092358
  77. MacDonald-Ramos K, 2021, ANN HEPATOL, V23, DOI 10.1016/j.aohep.2020.08.072
  78. Manigrasso MR, 2005, J CLIN ENDOCR METAB, V90, P5876, DOI 10.1210/jc.2005-0281
  79. Manna P, 2015, METAB SYNDR RELAT D, V13, P423, DOI 10.1089/met.2015.0095
  80. Masuoka HC, 2013, ANN NY ACAD SCI, V1281, P106, DOI 10.1111/nyas.12016
  81. MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883
  82. Matthews VB, 2010, DIABETOLOGIA, V53, P2431, DOI 10.1007/s00125-010-1865-y
  83. Mauer J, 2015, TRENDS IMMUNOL, V36, P92, DOI 10.1016/j.it.2014.12.008
  84. McMurray F, 2016, OBESITY, V24, P2301, DOI 10.1002/oby.21654
  85. Medina J, 2004, DIABETES CARE, V27, P2057, DOI 10.2337/diacare.27.8.2057
  86. Mehlem A, 2013, NAT PROTOC, V8, P1149, DOI 10.1038/nprot.2013.055
  87. Mingomataj EC, 2016, CLIN REV ALLERG IMMU, V50, P97, DOI 10.1007/s12016-015-8514-7
  88. Moreira GV, 2018, J NUTR BIOCHEM, V62, P143, DOI 10.1016/j.jnutbio.2018.07.009
  89. Nair Anroop B, 2016, J Basic Clin Pharm, V7, P27, DOI 10.4103/0976-0105.177703
  90. Nakagawa S, 2007, BIOL REV, V82, P591, DOI 10.1111/j.1469-185X.2007.00027.x
  91. Nehmi Victor Abou, 2021, J Integr Med, V19, P439, DOI 10.1016/j.joim.2021.05.002
  92. Nielsen FH, 2010, NUTR REV, V68, P333, DOI 10.1111/j.1753-4887.2010.00293.x
  93. Oliveira Ernesto Pereira de, 2005, J. Bras. Patol. Med. Lab., V41, P237, DOI 10.1590/S1676-24442005000400004
  94. Perlemuter G, 2005, LIVER INT, V25, P946, DOI 10.1111/j.1478-3231.2005.01126.x
  95. Petersen AMW, 2005, J APPL PHYSIOL, V98, P1154, DOI 10.1152/japplphysiol.00164.2004
  96. Piccinin E, 2019, NAT REV GASTRO HEPAT, V16, P160, DOI 10.1038/s41575-018-0089-3
  97. Pilchova I, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6797460
  98. Rani V, 2016, LIFE SCI, V148, P183, DOI 10.1016/j.lfs.2016.02.002
  99. Rayman MP, 2012, LANCET, V379, P1256, DOI 10.1016/S0140-6736(11)61452-9
  100. Reynolds AN, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003053
  101. Ribeiro E.B., 2020, STUDIES NATURAL PROD, V29, P161
  102. Ropelle ER, 2010, PLOS BIOL, V8, DOI 10.1371/journal.pbio.1000465
  103. Rosenzweig T, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22084193
  104. Sabater-Molina M, 2009, J PHYSIOL BIOCHEM, V65, P315, DOI 10.1007/BF03180584
  105. Sabio G, 2008, SCIENCE, V322, P1539, DOI 10.1126/science.1160794
  106. Samuelsen ABC, 2014, MOL NUTR FOOD RES, V58, P183, DOI 10.1002/mnfr.201300338
  107. Santamarina AB, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0141227
  108. Shin SK, 2018, PFLUG ARCH EUR J PHY, V470, P1721, DOI 10.1007/s00424-018-2195-z

Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/08
Artigos e Materiais de Revistas Científicas - LIM/26
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