Dynamic cerebral autoregulation: A marker of post-operative delirium?
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Citações na Scopus
21
Tipo de produção
article
Data de publicação
2019
Título da Revista
ISSN da Revista
Título do Volume
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ELSEVIER IRELAND LTD
Autores
Citação
CLINICAL NEUROPHYSIOLOGY, v.130, n.1, p.101-108, 2019
Resumo
Objective: We investigated the potential association of cerebral autoregulation (CA) with postoperative delirium (PD), a common complication of cardiac surgery with cardiopulmonary bypass (CPB). Methods: In patients undergoing coronary artery bypass graft (CABG) surgery with CPB, cerebral blood flow velocity (CBFV) and blood pressure (BP) were continuously recorded during 5-min preoperatively (T1), after 24 h (T2), and 7 days after procedure (T3). Prospective multivariate logistic regression analysis was performed to determine the independent risk factors of PD. Autoregulation index (ARI) was calculated from the CBFV response to a step change in BP derived by transfer function analysis. Results: In 67 patients, mean age 64.3 +/- 9.5 years, CA was depressed at T2 as shown by values of ARI (3.9 +/- 1.7), compared to T1 (5.6 +/- 1.7) and T3 (5.5 +/- 1.8) (p < 0.001). Impaired CA was found in 37 (55%) patients at T2 and in 7 patients (20%) at T3. Lower ARI at T1 and T2 were predictors of PD (p = 0.003). Conclusion: Dynamic CA was impaired after CABG surgery with CPB and was a significant independent risk factor of PD. Significance: Assessment of CA before and after surgery could have considerable potential for early identification of patients at risk of PD, thus reducing poor outcomes and length of stay.
Palavras-chave
Cardiac surgery, Cardiopulmonary bypass, Cerebral blood flow, Left ventricular ejection fraction
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Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/08