Temporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | PIMENTEL, Victor F. | |
dc.contributor.author | MORGADO, Mariza G. | |
dc.contributor.author | BELLO, Gonzalo | |
dc.contributor.author | GUIMARAES, Mark D. C. | |
dc.contributor.author | CASTILHO, Euclides A. | |
dc.contributor.author | VELOSO, Valdilea G. | |
dc.contributor.author | GUIMARAES, Monick L. | |
dc.date.accessioned | 2016-09-09T19:20:23Z | |
dc.date.available | 2016-09-09T19:20:23Z | |
dc.date.issued | 2013 | |
dc.description.abstract | HIV-1 molecular epidemiology studies carried out in Rio de Janeiro, Brazil have identified the prevalence of subtypes B, F1 and BF1 recombinants. A high percentage of HIV-1 subtype B isolates in Rio de Janeiro harbor the GWG motif at the V3 tip (B variant) instead of the canonical GPG motif (B variant). To trace the dynamics of the HIV-1 variants over time in different exposure categories in Rio de Janeiro, the HIV-1 proviral DNA from heterosexual men (HET) and men who have sex with men (MSM) from two distinct time periods (1990-1992 and 2008-2010) were extracted, and the env-gp120 region was amplified. Neighbor-joining phylogenetic analysis was performed to determine the viral subtype, and Bayesian analysis was used to trace the HIV-1 transmission networks. A predominance of subtype B was observed in both study periods, independent of the exposure risk category. An increase of non-B subtypes was observed in the HET group, but these subtypes were maintained among the MSM group. The distribution of HIV-1 subtype B signatures in the first and second periods studied were, respectively, HET (GPG) [44.8-51.5%], (GWG) [13.8-33.3%], and (GXG) [41.4-15.2%] and MSM (GPG) [34-50%], (GWG) [55.3-30.6%], and (GXG) [10.7-19.4%]. In the first period, an association between GWG and MSM was verified while a significant reduction of this association was observed during the second period. The phylogenetic tree and the BaTS program detected the clustering of isolates only according to the B signatures but not by exposure risk category. Our findings indicate a stable prevalence of HIV-1 subtypes B and F over time in Rio de Janeiro and further suggest that the B subclade of subtype B was possibly introduced into the MSM group in this area of Brazil. | |
dc.description.index | MEDLINE | |
dc.description.sponsorship | CNPq | |
dc.description.sponsorship | FAPERJ | |
dc.identifier.citation | AIDS RESEARCH AND HUMAN RETROVIRUSES, v.29, n.12, p.1553-1561, 2013 | |
dc.identifier.doi | 10.1089/aid.2013.0050 | |
dc.identifier.eissn | 1931-8405 | |
dc.identifier.issn | 0889-2229 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/15995 | |
dc.language.iso | eng | |
dc.relation.ispartof | AIDS Research and Human Retroviruses | |
dc.rights | restrictedAccess | |
dc.subject.other | human-immunodeficiency-virus | |
dc.subject.other | subtype-b strains | |
dc.subject.other | drug-resistance | |
dc.subject.other | sao-paulo | |
dc.subject.other | slower progression | |
dc.subject.other | evolutionary rates | |
dc.subject.other | southern brazil | |
dc.subject.other | v3 region | |
dc.subject.other | prevalence | |
dc.subject.other | identification | |
dc.subject.wos | Immunology | |
dc.subject.wos | Infectious Diseases | |
dc.subject.wos | Virology | |
dc.title | Temporal Trends and Molecular Epidemiology of HIV Type 1 Infection in Rio de Janeiro, Brazil | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.author.external | PIMENTEL, Victor F.:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil | |
hcfmusp.author.external | MORGADO, Mariza G.:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil | |
hcfmusp.author.external | BELLO, Gonzalo:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil | |
hcfmusp.author.external | GUIMARAES, Mark D. C.:Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil | |
hcfmusp.author.external | VELOSO, Valdilea G.:Fiocruz MS, Evandro Chagas Res Inst, BR-21040360 Rio De Janeiro, Brazil | |
hcfmusp.author.external | GUIMARAES, Monick L.:Inst Oswaldo Cruz, BR-20001 Rio De Janeiro, Brazil | |
hcfmusp.citation.scopus | 10 | |
hcfmusp.contributor.author-fmusphc | EUCLIDES AYRES DE CASTILHO | |
hcfmusp.description.beginpage | 1553 | |
hcfmusp.description.endpage | 1561 | |
hcfmusp.description.issue | 12 | |
hcfmusp.description.volume | 29 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 23987184 | |
hcfmusp.origem.scopus | 2-s2.0-84888331103 | |
hcfmusp.origem.wos | WOS:000327218000004 | |
hcfmusp.relation.reference | Alcalde R, 2012, VIROL J, V9, DOI 10.1186/1743-422X-9-156 | |
hcfmusp.relation.reference | Araujo AF, 2010, AIDS RES HUM RETROV, V26, P1249, DOI 10.1089/aid.2010.0068 | |
hcfmusp.relation.reference | Bello G, 2007, INFECT GENET EVOL, V7, P263, DOI 10.1016/j.meegid.2006.11.002 | |
hcfmusp.relation.reference | Bongertz V, 2000, J ACQ IMMUN DEF SYND, V23, P184 | |
hcfmusp.relation.reference | Brazilian Ministry of Healthy, 2011, B EPIDEMIOLOGICO AID | |
hcfmusp.relation.reference | Brigido LFM, 2011, AIDS RES HUM RETROV, V27, P339, DOI 10.1089/aid.2010.0157 | |
hcfmusp.relation.reference | Cabral VP, 2006, MEM I OSWALDO CRUZ, V101, P881, DOI 10.1590/S0074-02762006000800010 | |
hcfmusp.relation.reference | Caride E, 2001, VIRUS GENES, V23, P193, DOI 10.1023/A:1011812810397 | |
hcfmusp.relation.reference | Carvalho BC, 2011, AIDS RES HUM RETROV, V27, P1081, DOI [10.1089/AID.2010.0334, 10.1089/aid.2010.0334] | |
hcfmusp.relation.reference | Casseb J, 1998, BRAZ J MED BIOL RES, V31, P1243, DOI 10.1590/S0100-879X1998001000002 | |
hcfmusp.relation.reference | Casseb Jorge, 2002, International Journal of Infectious Diseases, V6, P164, DOI 10.1016/S1201-9712(02)90105-0 | |
hcfmusp.relation.reference | CHU SY, 1992, AM J PUBLIC HEALTH, V82, P220, DOI 10.2105/AJPH.82.2.220 | |
hcfmusp.relation.reference | Couto-Fernandez JC, 2005, MEM I OSWALDO CRUZ, V100, P73, DOI 10.1590/S0074-02762005000100014 | |
hcfmusp.relation.reference | Couto-Fernandez JC, 2006, AIDS RES HUM RETROV, V22, P207, DOI 10.1089/aid.2006.22.207 | |
hcfmusp.relation.reference | Covas DT, 1998, J ACQ IMMUN DEF SYND, V19, P74 | |
hcfmusp.relation.reference | de Brito A, 2006, CLIN INFECT DIS, V43, P1476 | |
hcfmusp.relation.reference | Delatorre EO, 2012, AIDS RES HUM RETROV, V28, P1369, DOI 10.1089/aid.2011.0381 | |
hcfmusp.relation.reference | DELWART EL, 1993, SCIENCE, V262, P1257, DOI 10.1126/science.8235655 | |
hcfmusp.relation.reference | Diaz RS, 2008, VIROLOGY, V381, P184, DOI 10.1016/j.virol.2008.08.014 | |
hcfmusp.relation.reference | Franca RFO, 2011, AIDS RES HUM RETROV, V27, P903, DOI [10.1089/AID.2010.0266, 10.1089/aid.2010.0266] | |
hcfmusp.relation.reference | GUIMARAES MDC, 1995, AM J EPIDEMIOL, V142, P538 | |
hcfmusp.relation.reference | Guimaraes MDC, 1997, ARCH INTERN MED, V157, P1362, DOI 10.1001/archinte.157.12.1362 | |
hcfmusp.relation.reference | Guimaraes ML, 2001, J CLIN VIROL, V21, P143, DOI 10.1016/S1386-6532(01)00158-5 | |
hcfmusp.relation.reference | Guimaraes ML, 2010, INFECT GENET EVOL, V10, P1094, DOI 10.1016/j.meegid.2010.07.001 | |
hcfmusp.relation.reference | Guimaraes Monick Lindenmeyer, 2002, AIDS Research and Human Retroviruses, V18, P1261, DOI 10.1089/088922202320886307 | |
hcfmusp.relation.reference | Hemelaar J, 2011, AIDS, V25, P679, DOI 10.1097/QAD.0b013e328342ff93 | |
hcfmusp.relation.reference | KIMURA M, 1980, J MOL EVOL, V16, P111, DOI 10.1007/BF01731581 | |
hcfmusp.relation.reference | Koichiro T., 2011, MOL BIOL EVOL, V28, P2731, DOI 10.1093/M0LBEV/MSR121 | |
hcfmusp.relation.reference | Machado LFA, 2009, AIDS RES HUM RETROV, V25, P961, DOI 10.1089/aid.2009.0027 | |
hcfmusp.relation.reference | MORGADO MG, 1994, AIDS RES HUM RETROV, V10, P569, DOI 10.1089/aid.1994.10.569 | |
hcfmusp.relation.reference | Morgado MG, 1996, MEM I OSWALDO CRUZ, V91, P339, DOI 10.1590/S0074-02761996000300015 | |
hcfmusp.relation.reference | Morgado MG, 1998, J ACQ IMMUN DEF SYND, V18, P488 | |
hcfmusp.relation.reference | Parker J, 2008, INFECT GENET EVOL, V8, P239, DOI 10.1016/j.meegid.2007.08.001 | |
hcfmusp.relation.reference | Posada D, 2008, MOL BIOL EVOL, V25, P1253, DOI 10.1093/molbev/msn083 | |
hcfmusp.relation.reference | POTTS KE, 1993, AIDS, V7, P1191, DOI 10.1097/00002030-199309000-00007 | |
hcfmusp.relation.reference | Ray S., 2009, SIMPLOT V3 5 1 | |
hcfmusp.relation.reference | Ronquist F, 2003, BIOINFORMATICS, V19, P1572, DOI 10.1093/bioinformatics/btg180 | |
hcfmusp.relation.reference | SABINO EC, 1994, J VIROL, V68, P6340 | |
hcfmusp.relation.reference | Santoro-Lopes G, 2000, AIDS RES HUM RETROV, V16, P953, DOI 10.1089/08892220050058362 | |
hcfmusp.relation.reference | SLATKIN M, 1989, GENETICS, V123, P603 | |
hcfmusp.relation.reference | Stefani MMA, 2007, J CLIN VIROL, V39, P205, DOI 10.1016/j.jcv.2007.04.012 | |
hcfmusp.relation.reference | Sucupira MC, 2012, PLOS ONE, V7 | |
hcfmusp.relation.reference | Teixeira SLM, 2006, J MED VIROL, V78, P764, DOI 10.1002/jmv.20621 | |
hcfmusp.relation.reference | Thompson JD, 1997, NUCLEIC ACIDS RES, V25, P4876, DOI 10.1093/nar/25.24.4876 | |
hcfmusp.relation.reference | Wang TH, 2001, J VIROL, V75, P11686, DOI 10.1128/JVI.75.23.11686-11699.2001 | |
hcfmusp.scopus.lastupdate | 2024-05-17 | |
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relation.isAuthorOfPublication.latestForDiscovery | 5dfd35f7-d23f-47c6-889c-295135fb1b6a |
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