Influence of ACE Polymorphism on Echocardiographic Data of Patients with Heart Failure

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, Silene Jacinto da
dc.contributor.authorRASSI, Salvador
dc.contributor.authorPEREIRA, Alexandre da Costa
dc.date.accessioned2019-06-05T14:42:47Z
dc.date.available2019-06-05T14:42:47Z
dc.date.issued2019
dc.description.abstractAbstract Background: Angiotensin converting enzyme (ACE) polymorphism has been associated with different clinical and echocardiographic parameters in patients with heart failure (HF). However, no studies have been investigated such association with HF caused by Chagas disease. Objectives: To perform a genetic study to evaluate the frequency of ACE polymorphism in patients with HF caused by Chagas disease attending a university hospital in the central-west region and its association with echocardiographic findings. Methods: Descriptive study of ACE polymorphism (I/D) and echocardiographic data of 103 patients with HF caused by Chagas disease. Echocardiographic parameters were compared between the genotypes using the ANOVA test. Results: Genotypic distribution of the ACE polymorphism was 16.5% DD, 57.3% DI and 26.2% II. There was no statistically significant difference in the distribution of genotypes between men and women. The echocardiographic findings were: left ventricular ejection fraction: 43.8 ± 14.8 (DD) vs. 42.3 ± 11.6 (ID) vs. 44.9 ± 13.0 (II), p = 0.664; left ventricular diastolic diameter: 59.2 ± 9.7 (DD) vs. 60.3 ± 7.6 (ID) vs. 59.7 ± 78.1 (II), p = 0.879; left ventricular systolic diameter: 48.6 ± 12.8 (DD) vs. 50.6 ± 9.7 (ID) vs. 49.3 ± 11.9 (II), p = 0.753; and left atrial volume: 44.9 ± 10.1 (DD) vs. 40.9 ± 9.6 (ID) vs. 38.2 ± 7.8 (II), p = 0.068. Significant correlation coefficients were found for gender, age, ethnicity, heart rate and dyslipidemia. Conclusion: ACE polymorphism was not associated with echocardiographic findings in patients with HF caused by Chagas disease.eng
dc.description.indexSciELOeng
dc.identifier.citationINTERNATIONAL JOURNAL OF CARDIOVASCULAR SCIENCES, v.32, n.1, p.55-60, 2019
dc.identifier.doi10.5935/2359-4802.20180081
dc.identifier.issn2359-5647
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32090
dc.language.isoengpor
dc.publisherSociedade Brasileira de Cardiologiaeng
dc.relation.ispartofInternational Journal of Cardiovascular Sciences
dc.rightsopenAccesseng
dc.rights.holderCopyright Sociedade Brasileira de Cardiologiaeng
dc.subjectHeart Failureeng
dc.subjectAngiotensinseng
dc.subjectPolymorphism, Geneticeng
dc.subjectChagas Diseaseeng
dc.subjectEchocardiography/methodseng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titleInfluence of ACE Polymorphism on Echocardiographic Data of Patients with Heart Failureeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSILVA, Silene Jacinto da:Universidade Federal de Goiás, Brazil
hcfmusp.author.externalRASSI, Salvador:Universidade Federal de Goiás, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.beginpage55
hcfmusp.description.endpage60
hcfmusp.description.issue1
hcfmusp.description.volume32
hcfmusp.origemsciELO
hcfmusp.origem.scieloSCIELO:S2359-56472019000100055
hcfmusp.origem.scopus2-s2.0-85169114383
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