Lobar pulmonary perfusion quantification with dual-energy CT angiography: Interlobar variability and relationship with regional clot burden in pulmonary embolism

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEE, Hye Ju
dc.contributor.authorWANDERLEY, Mark
dc.contributor.authorRUBIN, Vivian Cardinal da Silva
dc.contributor.authorRODRIGUES, Ana Clara Tude
dc.contributor.authorDINIZ, Amanda Rocha
dc.contributor.authorPARGA, Jose Rodrigues
dc.contributor.authorAMATO, Marcelo Britto Passos
dc.date.accessioned2022-08-12T17:05:47Z
dc.date.available2022-08-12T17:05:47Z
dc.date.issued2022
dc.description.abstractPurpose: Semi-automated lobar segmentation tools enable an anatomical assessment of regional pulmonary perfusion with Dual-Energy CTA (DE-CTA). We aimed to quantify lobar pulmonary perfusion with DE-CTA, analyze the perfusion distribution among the pulmonary lobes in subjects without cardiopulmonary diseases and assess the correlation between lobar perfusion and regional endoluminal clots in patients with acute pulmonary embolism (PE). Methods: We evaluated 151 consecutive subjects with suspected PE and without cardiopulmonary comorbidities. DE-CTA derived perfused blood volume (PBV) of each pulmonary lobe was measured applying a semi-automated lobar segmentation technique. In patients with PE, blood clot location was assessed, and CT-based vascular obstruction index of each lobe (CTOIlobe) was calculated and classified into three groups: CTOIlobe= 0, low CTOIlobe (1-50%) and high CTOIlobe (>50%). Results: Among patients without PE (103/151, 68.2%), median lobar PBV was 13.7% (IQR 10.2-18.0%); the right middle lobe presented lower PBV when compared to all the other lobes (p < .001). In patients with PE (48/151, 31.8%), lobar PBV was 12.6% (IQR 9.6-15.7%), 13.7% (IQR 10.1-16.7%) and 6.5% (IQR 5.1-10.2%) in the lobes with CTOIlobe= 0, low CTOIlobe and high CTOIlobe scores, respectively, with a significantly decreased PBV in the lobes with high CTOIlobe score (p < .001). ROC analysis of lobar PBV for prediction of high CTOIlobe score revealed AUC of 0.847 (95%CI 0.785-0.908).eng
dc.description.indexPubMedeng
dc.description.sponsorshipFinanciadora de Estudos e Projetos-FINEP [01140089000]
dc.identifier.citationEUROPEAN JOURNAL OF RADIOLOGY OPEN, v.9, article ID 100428, 8p, 2022
dc.identifier.doi10.1016/j.ejro.2022.100428
dc.identifier.eissn2352-0477
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/48334
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofEuropean Journal of Radiology Open
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIEReng
dc.subjectPulmonary embolismeng
dc.subjectComputed tomography angiographyeng
dc.subjectPulmonary perfusioneng
dc.subjectBlood volumeeng
dc.subjectDual-energy computed tomography (DECT)eng
dc.subject.othervolume lung pbveng
dc.subject.otherblood-volumeeng
dc.subject.othergravityeng
dc.subject.otherfloweng
dc.subject.othersupineeng
dc.subject.otherproneeng
dc.subject.othergradientseng
dc.subject.otherseverityeng
dc.subject.otherdensityeng
dc.subject.wosRadiology, Nuclear Medicine & Medical Imagingeng
dc.titleLobar pulmonary perfusion quantification with dual-energy CT angiography: Interlobar variability and relationship with regional clot burden in pulmonary embolismeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcHYE JU LEE
hcfmusp.contributor.author-fmusphcMARK WANDERLEY
hcfmusp.contributor.author-fmusphcVIVIAN CARDINAL DA SILVA RUBIN
hcfmusp.contributor.author-fmusphcANA CLARA TUDE RODRIGUES
hcfmusp.contributor.author-fmusphcAMANDA ROCHA DINIZ KIMURA
hcfmusp.contributor.author-fmusphcJOSE RODRIGUES PARGA FILHO
hcfmusp.contributor.author-fmusphcMARCELO BRITTO PASSOS AMATO
hcfmusp.description.articlenumber100428
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed35712646
hcfmusp.origem.scopus2-s2.0-85131928175
hcfmusp.origem.wosWOS:000814566300001
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
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