Cerebellar degeneration and progressive ataxia associated with HIV-virus infection
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Citações na Scopus
8
Tipo de produção
article
Data de publicação
2018
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
PEDROSO, Jose Luiz
VALE, Thiago Cardoso
GAMA, Maria Thereza Drumond
RIBAS, Gustavo
KRISTOCHIK, Julio C. G.
GERMINIANI, Francisco M. B.
TEIVE, Helio A. G.
BARSOTTINI, Orlando G.
Citação
PARKINSONISM & RELATED DISORDERS, v.54, p.95-98, 2018
Resumo
Introduction: The spectrum of neurologic disorders associated with HIV infection is very broad, resulting from direct virus invasion, opportunistic infections, malignancies and toxic effects of drugs. Methods: Among a large cohort of ataxia patients (N = 1050) evaluated between 2008 and 2017, we detected four patients with HIV-infection who developed a pure progressive cerebellar ataxia syndrome combined with cerebellar atrophy. Results: Adverse drug effects, opportunistic infections and malignancies as well as immune reconstitution syndrome were ruled out based on history and laboratory data. The exact pathophysiological mechanisms of ataxia in HIV patients is not very clear, but seems to be immune-mediated or a direct neurotoxic virus effect leading to apoptosis of Purkinje and granular cells. Conclusion: HIV infection should be investigated in adult patients with undetermined sporadic progressive pure ataxia with cerebellar atrophy.
Palavras-chave
HIV, Ataxia, Cerebellum
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