Whole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcification

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVRIES, Paul S. de
dc.contributor.authorCONOMOS, Matthew P.
dc.contributor.authorSINGH, Kuldeep
dc.contributor.authorNICHOLSON, Christopher J.
dc.contributor.authorJAIN, Deepti
dc.contributor.authorHASBANI, Natalie R.
dc.contributor.authorJIANG, Wanlin
dc.contributor.authorLEE, Sujin
dc.contributor.authorCARDENAS, Christian L. Lino
dc.contributor.authorLUTZ, Sharon M.
dc.contributor.authorWONG, Doris
dc.contributor.authorGUO, Xiuqing
dc.contributor.authorYAO, Jie
dc.contributor.authorYOUNG, Erica P.
dc.contributor.authorTCHEANDJIEU, Catherine
dc.contributor.authorHILLIARD, Austin T.
dc.contributor.authorBIS, Joshua C.
dc.contributor.authorBIELAK, Lawrence F.
dc.contributor.authorBROWN, Michael R.
dc.contributor.authorMUSHAROFF, Shaila
dc.contributor.authorCLARKE, Shoa L.
dc.contributor.authorTERRY, James G.
dc.contributor.authorPALMER, Nicholette D.
dc.contributor.authorYANEK, Lisa R.
dc.contributor.authorXU, Huichun
dc.contributor.authorHEARD-COSTA, Nancy
dc.contributor.authorWESSEL, Jennifer
dc.contributor.authorSELVARAJ, Margaret Sunitha
dc.contributor.authorLI, Rebecca H.
dc.contributor.authorSUN, Xiao
dc.contributor.authorTURNER, Adam W.
dc.contributor.authorSTILP, Adrienne M.
dc.contributor.authorKHAN, Alyna
dc.contributor.authorNEWMAN, Anne B.
dc.contributor.authorRASHEED, Asif
dc.contributor.authorFREEDMAN, Barry I.
dc.contributor.authorKRAL, Brian G.
dc.contributor.authorMCHUGH, Caitlin P.
dc.contributor.authorHODONSKY, Chani
dc.contributor.authorSALEHEEN, Danish
dc.contributor.authorHERRINGTON, David M.
dc.contributor.authorJACOBS JR., David R.
dc.contributor.authorNICKERSON, Deborah A.
dc.contributor.authorBOERWINKLE, Eric
dc.contributor.authorWANG, Fei Fei
dc.contributor.authorHEISS, Gerardo
dc.contributor.authorJUN, Goo
dc.contributor.authorKINNEY, Greg L.
dc.contributor.authorSIGURSLID, Haakon H.
dc.contributor.authorDODDAPANENI, Harshavardhan
dc.contributor.authorHALL, Ira M.
dc.contributor.authorBENSENOR, Isabela M.
dc.contributor.authorBROOME, Jai
dc.contributor.authorCRAPO, James D.
dc.contributor.authorWILSON, James G.
dc.contributor.authorSMITH, Jennifer A.
dc.contributor.authorBLANGERO, John
dc.contributor.authorVARGAS, Jose D.
dc.contributor.authorMOSQUERA, Jose Verdezoto
dc.contributor.authorSMITH, Joshua D.
dc.contributor.authorVIAUD-MARTINEZ, Karine A.
dc.contributor.authorRYAN, Kathleen A.
dc.contributor.authorYOUNG, Kendra A.
dc.contributor.authorTAYLOR, Kent D.
dc.contributor.authorLANGE, Leslie A.
dc.contributor.authorEMERY, Leslie S.
dc.contributor.authorBITTENCOURT, Marcio S.
dc.contributor.authorBUDOFF, Matthew J.
dc.contributor.authorMONTASSER, May E.
dc.contributor.authorYU, Miao
dc.contributor.authorMAHANEY, Michael C.
dc.contributor.authorMAHAMDEH, Mohammed S.
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorFRANCESCHINI, Nora
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorNATARAJAN, Pradeep
dc.contributor.authorWONG, Quenna
dc.contributor.authorMATHIAS, Rasika A.
dc.contributor.authorGIBBS, Richard A.
dc.contributor.authorDO, Ron
dc.contributor.authorMEHRAN, Roxana
dc.contributor.authorTRACY, Russell P.
dc.contributor.authorKIM, Ryan W.
dc.contributor.authorNELSON, Sarah C.
dc.contributor.authorDAMRAUER, Scott M.
dc.contributor.authorKARDIA, Sharon L. R.
dc.contributor.authorRICH, Stephen S.
dc.contributor.authorFUSTER, Valentin
dc.contributor.authorNAPOLIONI, Valerio
dc.contributor.authorZHAO, Wei
dc.contributor.authorTIAN, Wenjie
dc.contributor.authorYIN, Xianyong
dc.contributor.authorI, Yuan- Min
dc.contributor.authorMANNING, Alisa K.
dc.contributor.authorPELOSO, Gina
dc.contributor.authorKELLY, Tanika N.
dc.contributor.authorO'DONNELL, Christopher J.
dc.contributor.authorMORRISON, Alanna C.
dc.contributor.authorCURRAN, Joanne E.
dc.contributor.authorZAPOL, Warren M.
dc.contributor.authorBOWDEN, Donald W.
dc.contributor.authorBECKER, Lewis C.
dc.contributor.authorCORREA, Adolfo
dc.contributor.authorMITCHELL, Braxton D.
dc.contributor.authorPSATY, Bruce M.
dc.contributor.authorCARR, John Jeffrey
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorASSIMES, Themistocles L.
dc.contributor.authorSTITZIEL, Nathan O.
dc.contributor.authorHOKANSON, John E.
dc.contributor.authorLAURIE, Cecelia A.
dc.contributor.authorROTTER, Jerome I.
dc.contributor.authorVASAN, Ramachandran S.
dc.contributor.authorPOST, Wendy S.
dc.contributor.authorPEYSER, Patricia A.
dc.contributor.authorMILLER, Clint L.
dc.contributor.authorMALHOTRA, Rajeev
dc.date.accessioned2024-02-15T14:39:26Z
dc.date.available2024-02-15T14:39:26Z
dc.date.issued2023
dc.description.abstractCoronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four known loci and identified two additional loci associated with CAC (ARSE and MMP16), with evidence of significant associations in replication analyses for both novel loci. Functional assays of ARSE and MMP16 in human vascular smooth muscle cells (VSMCs) demonstrate that ARSE is a promoter of VSMC calcification and VSMC phenotype switching from a contractile to a calcifying or osteogenic phenotype. Furthermore, we show that the association of variants near ARSE with reduced CAC is likely explained by reduced ARSE expression with the G allele of enhancer variant rs5982944. Our study highlights ARSE as an important contributor to atherosclerotic vascular calcification and a potential drug target for vascular calcific disease. de Vries, Conomos, Singh and Nicholson et al. identify two additional loci associated with coronary artery calcification (ARSE and MMP16) via a genome-wide association study in 22,400 participants from multiple ancestral groups and prove that ARSE is a mediator of vascular smooth muscle cell calcification and phenotype switching.eng
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) [R01HL146860]
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (NHLBI) [18TPA34230025]
dc.description.sponsorshipAmerican Heart Association [U01HL137162]
dc.description.sponsorshipNHLBI grant [3R01HL-117626-02S1, HHSN268201800002I, R01HL-120393, U01HL-120393, HHSN268201800001I]
dc.description.sponsorshipNHLBI
dc.description.sponsorshipWild Family Foundation [18CVD02]
dc.description.sponsorshipFondation Leducq
dc.description.sponsorshipChan Zuckerberg Initiative
dc.description.sponsorshipSilicon Valley Community Foundation
dc.description.sponsorshipVA Million Veteran Program
dc.identifier.citationNATURE CARDIOVASCULAR RESEARCH, v.2, n.12, p.1159-+, 2023
dc.identifier.doi10.1038/s44161-023-00375-y
dc.identifier.eissn2731-0590
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57857
dc.language.isoeng
dc.publisherSPRINGERNATUREeng
dc.relation.ispartofNature Cardiovascular Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPRINGERNATUREeng
dc.subject.othersmooth-muscle-cellseng
dc.subject.othermatrix metalloproteinaseseng
dc.subject.otherwide associationeng
dc.subject.othercalcium scoreeng
dc.subject.otherpopulation-structureeng
dc.subject.otherrisk classificationeng
dc.subject.otherin-vitroeng
dc.subject.otherexpressioneng
dc.subject.otherfibronectineng
dc.subject.otherdeficiencyeng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titleWhole-genome sequencing uncovers two loci for coronary artery calcification and identifies ARSE as a regulator of vascular calcificationeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryPaquistão
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoit
hcfmusp.affiliation.countryisopk
hcfmusp.author.externalVRIES, Paul S. de:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA
hcfmusp.author.externalCONOMOS, Matthew P.:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalSINGH, Kuldeep:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalNICHOLSON, Christopher J.:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalJAIN, Deepti:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalHASBANI, Natalie R.:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA
hcfmusp.author.externalJIANG, Wanlin:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalLEE, Sujin:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalCARDENAS, Christian L. Lino:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalLUTZ, Sharon M.:Harvard Med Sch, Dept Populat Med, PRecisiOn Med Translat Res PROMoTeR Ctr, Boston, MA 02115 USA; Harvard Pilgrim Hlth Care Inst, Boston, MA USA; Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA
hcfmusp.author.externalWONG, Doris:Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
hcfmusp.author.externalGUO, Xiuqing:Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USA
hcfmusp.author.externalYAO, Jie:Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USA
hcfmusp.author.externalYOUNG, Erica P.:Washington Univ, Sch Med, Dept Internal Med, Cardiovasc Div, St Louis, MO 63110 USA
hcfmusp.author.externalTCHEANDJIEU, Catherine:VA Palo Alto Healthcare Syst, Palo Alto, CA USA; Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
hcfmusp.author.externalHILLIARD, Austin T.:VA Palo Alto Healthcare Syst, Palo Alto, CA USA; Palo Alto Vet Inst Res, Palo Alto, CA USA
hcfmusp.author.externalBIS, Joshua C.:Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
hcfmusp.author.externalBIELAK, Lawrence F.:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalBROWN, Michael R.:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA
hcfmusp.author.externalMUSHAROFF, Shaila:VA Palo Alto Healthcare Syst, Palo Alto, CA USA; Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
hcfmusp.author.externalCLARKE, Shoa L.:VA Palo Alto Healthcare Syst, Palo Alto, CA USA; Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
hcfmusp.author.externalTERRY, James G.:Vanderbilt Univ, Med Ctr, Dept Radiol, Vanderbilt Translat & Clin Cardiovasc Res Ctr, Nashville, TN 37232 USA
hcfmusp.author.externalPALMER, Nicholette D.:Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27101 USA
hcfmusp.author.externalYANEK, Lisa R.:Johns Hopkins Univ, Sch Med, Dept Med, Div Gen Internal Med, Baltimore, MD 21205 USA
hcfmusp.author.externalXU, Huichun:Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA
hcfmusp.author.externalHEARD-COSTA, Nancy:Boston Univ, Sch Med, Boston, MA 02118 USA; Boston Univ & Natl Heart Lung & Blood Inst Framin, Framingham, MA USA
hcfmusp.author.externalWESSEL, Jennifer:Indiana Univ, Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA; Indiana Univ, Diabet Translat Res Ctr, Indianapolis, IN 46204 USA
hcfmusp.author.externalSELVARAJ, Margaret Sunitha:Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA; Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA; Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA; Harvard Med Sch, Dept Med, Boston, MA 02115 USA
hcfmusp.author.externalLI, Rebecca H.:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalSUN, Xiao:Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA; Univ Illinois, Coll Med, Div Nephrol, Dept Med, Chicago, IL USA
hcfmusp.author.externalTURNER, Adam W.:Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
hcfmusp.author.externalSTILP, Adrienne M.:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalKHAN, Alyna:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalNEWMAN, Anne B.:Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA
hcfmusp.author.externalRASHEED, Asif:Ctr NonCommunicable Dis, Karachi, Pakistan
hcfmusp.author.externalFREEDMAN, Barry I.:Wake Forest Sch Med, Dept Internal Med, Sect Nephrol, Winston Salem, NC 27101 USA
hcfmusp.author.externalKRAL, Brian G.:Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA
hcfmusp.author.externalMCHUGH, Caitlin P.:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalHODONSKY, Chani:Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
hcfmusp.author.externalSALEHEEN, Danish:Ctr NonCommunicable Dis, Karachi, Pakistan; Columbia Univ, Dept Med, Irving Med Ctr, New York, NY USA; Columbia Univ, Irving Med Ctr, Dept Cardiol, New York, NY USA
hcfmusp.author.externalHERRINGTON, David M.:Wake Forest Sch Med, Dept Internal Med, Sect Cardiovasc Med, Winston Salem, NC 27101 USA
hcfmusp.author.externalJACOBS JR., David R.:Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA
hcfmusp.author.externalNICKERSON, Deborah A.:Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA; Univ Washington, Northwest Genom Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalBOERWINKLE, Eric:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA; Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
hcfmusp.author.externalWANG, Fei Fei:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalHEISS, Gerardo:Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA
hcfmusp.author.externalJUN, Goo:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA
hcfmusp.author.externalKINNEY, Greg L.:Univ Colorado Denver Anschutz Med Campus, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA
hcfmusp.author.externalSIGURSLID, Haakon H.:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalDODDAPANENI, Harshavardhan:Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
hcfmusp.author.externalHALL, Ira M.:Yale Sch Med, Yale Ctr Genom Hlth, New Haven, CT USA
hcfmusp.author.externalBROOME, Jai:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalCRAPO, James D.:Natl Jewish Hlth, Dept Med, Denver, CO USA
hcfmusp.author.externalWILSON, James G.:Beth Israel Deaconess Med Ctr, Div Cardiol, Boston, MA 02215 USA
hcfmusp.author.externalSMITH, Jennifer A.:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA; Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA
hcfmusp.author.externalBLANGERO, John:Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX USA; Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Brownsville, TX USA
hcfmusp.author.externalVARGAS, Jose D.:Medstar Georgetown Univ Hosp, Medstar Heart & Vasc Inst, Washington, DC USA
hcfmusp.author.externalMOSQUERA, Jose Verdezoto:Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
hcfmusp.author.externalSMITH, Joshua D.:Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA; Univ Washington, Northwest Genom Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalVIAUD-MARTINEZ, Karine A.:Illumina Inc, Illumina Lab Serv, San Diego, CA USA
hcfmusp.author.externalRYAN, Kathleen A.:Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA
hcfmusp.author.externalYOUNG, Kendra A.:Univ Colorado Denver Anschutz Med Campus, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA
hcfmusp.author.externalTAYLOR, Kent D.:Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USA
hcfmusp.author.externalLANGE, Leslie A.:Univ Colorado Denver Anschutz Med Campus, Dept Med, Aurora, CO USA
hcfmusp.author.externalEMERY, Leslie S.:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalBUDOFF, Matthew J.:Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Dept Med, Torrance, CA 90509 USA
hcfmusp.author.externalMONTASSER, May E.:Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA
hcfmusp.author.externalYU, Miao:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalMAHANEY, Michael C.:Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX USA; Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Brownsville, TX USA
hcfmusp.author.externalMAHAMDEH, Mohammed S.:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalFORNAGE, Myriam:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA; Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Inst Mol Med, Houston, TX 77030 USA
hcfmusp.author.externalFRANCESCHINI, Nora:Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27515 USA
hcfmusp.author.externalNATARAJAN, Pradeep:Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA; Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA 02114 USA; Broad Inst Harvard & MIT, Program Med & Populat Genet, Cambridge, MA USA; Harvard Med Sch, Dept Med, Boston, MA 02115 USA
hcfmusp.author.externalWONG, Quenna:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalMATHIAS, Rasika A.:Johns Hopkins Univ, Sch Med, Dept Med, Div Gen Internal Med, Baltimore, MD 21205 USA; Johns Hopkins Univ, Sch Med, Dept Med, Div Allergy & Clin Immunol, Baltimore, MD 21205 USA
hcfmusp.author.externalGIBBS, Richard A.:Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA; Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
hcfmusp.author.externalDO, Ron:Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
hcfmusp.author.externalMEHRAN, Roxana:Icahn Sch Med Mt Sinai, New York, NY 10029 USA
hcfmusp.author.externalTRACY, Russell P.:Univ Vermont, Robert Larner MD Coll Med, Dept Pathol & Lab Med, Burlington, VT USA
hcfmusp.author.externalKIM, Ryan W.:Psomagen Inc, Rockville, MD USA
hcfmusp.author.externalNELSON, Sarah C.:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalDAMRAUER, Scott M.:Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA USA; Univ Penn, Perelman Sch Med, Dept Surg, Philadelphia, PA 19104 USA
hcfmusp.author.externalKARDIA, Sharon L. R.:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalRICH, Stephen S.:Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
hcfmusp.author.externalFUSTER, Valentin:Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain; Mt Sinai Heart Ctr, New York, NY USA
hcfmusp.author.externalNAPOLIONI, Valerio:Univ Camerino, Sch Biosci & Vet Med, Genom & Mol Epidemiol GAME Lab, Camerino, Italy
hcfmusp.author.externalZHAO, Wei:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalTIAN, Wenjie:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.author.externalYIN, Xianyong:Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA; Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA
hcfmusp.author.externalI, Yuan- Min:Univ Mississippi, Med Ctr, Dept Med, Jackson Heart Study, Jackson, MS 39216 USA
hcfmusp.author.externalMANNING, Alisa K.:Massachusetts Gen Hosp, Dept Med, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA; Broad Inst, Program Metab, Cambridge, MA USA; Broad Inst, Program Med & Populat Genet, Cambridge, MA USA
hcfmusp.author.externalPELOSO, Gina:Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
hcfmusp.author.externalKELLY, Tanika N.:Univ Illinois, Coll Med, Div Nephrol, Dept Med, Chicago, IL USA
hcfmusp.author.externalO'DONNELL, Christopher J.:VA Boston Healthcare Syst, Boston, MA USA; Brigham & Womens Hosp, Dept Med, 75 Francis St, Boston, MA 02115 USA
hcfmusp.author.externalMORRISON, Alanna C.:Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Human Genet Ctr, Houston, TX 77030 USA
hcfmusp.author.externalCURRAN, Joanne E.:Univ Texas Rio Grande Valley, Sch Med, Dept Human Genet, Brownsville, TX USA; Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Brownsville, TX USA
hcfmusp.author.externalZAPOL, Warren M.:Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
hcfmusp.author.externalBOWDEN, Donald W.:Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27101 USA
hcfmusp.author.externalBECKER, Lewis C.:Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA
hcfmusp.author.externalCORREA, Adolfo:Univ Mississippi, Med Ctr, Dept Med, Jackson Heart Study, Jackson, MS 39216 USA; Univ Mississippi, Med Ctr, Dept Populat Hlth Sci, Jackson, MS 39216 USA
hcfmusp.author.externalMITCHELL, Braxton D.:Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA; Baltimore Vet Adm Med Ctr, Geriatr Res & Educ Clin Ctr, Baltimore, MD USA
hcfmusp.author.externalPSATY, Bruce M.:Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA; Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA; Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA
hcfmusp.author.externalCARR, John Jeffrey:Vanderbilt Univ, Med Ctr, Dept Radiol, Vanderbilt Translat & Clin Cardiovasc Res Ctr, Nashville, TN 37232 USA
hcfmusp.author.externalASSIMES, Themistocles L.:VA Palo Alto Healthcare Syst, Palo Alto, CA USA; Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
hcfmusp.author.externalSTITZIEL, Nathan O.:Washington Univ, Sch Med, Dept Internal Med, Cardiovasc Div, St Louis, MO 63110 USA; Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA; Washington Univ, Sch Med, McDonnell Genome Inst, St Louis, MO USA
hcfmusp.author.externalHOKANSON, John E.:Univ Colorado Denver Anschutz Med Campus, Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA
hcfmusp.author.externalLAURIE, Cecelia A.:Univ Washington, Sch Publ Hlth, Dept Biostat, Genet Anal Ctr, Seattle, WA 98195 USA
hcfmusp.author.externalROTTER, Jerome I.:Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90509 USA
hcfmusp.author.externalVASAN, Ramachandran S.:Boston Univ & Natl Heart Lung & Blood Inst Framin, Framingham, MA USA; Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA; Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
hcfmusp.author.externalPOST, Wendy S.:Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA
hcfmusp.author.externalPEYSER, Patricia A.:Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
hcfmusp.author.externalMILLER, Clint L.:Univ Virginia, Sch Med, Ctr Publ Hlth Genom, Charlottesville, VA 22908 USA
hcfmusp.author.externalMALHOTRA, Rajeev:Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Cardiovasc Res Ctr,Div Cardiol, Boston, MA 02115 USA
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcISABELA JUDITH MARTINS BENSEñOR
hcfmusp.contributor.author-fmusphcMARCIO SOMMER BITTENCOURT
hcfmusp.contributor.author-fmusphcPAULO ANDRADE LOTUFO
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.beginpage1159
hcfmusp.description.endpage+
hcfmusp.description.issue12
hcfmusp.description.volume2
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-85178434924
hcfmusp.origem.wosWOS:001124837200021
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hcfmusp.publisher.countryENGLANDeng
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