AIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphisms

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPRATES, Gabriela da Silva
dc.contributor.authorMALTA, Fernanda M.
dc.contributor.authorGONCALVES, Fernanda de Toledo
dc.contributor.authorMONTEIRO, Mariana A.
dc.contributor.authorFONSECA, Luiz Augusto M.
dc.contributor.authorVEIGA, Ana Paula R.
dc.contributor.authorMAGRI, Marcello M. C.
dc.contributor.authorDUARTE, Alberto J. S.
dc.contributor.authorCASSEB, Jorge
dc.contributor.authorASSONE, Tatiane
dc.contributor.groupauthorADEE 3002 GRP
dc.date.accessioned2021-06-17T13:56:03Z
dc.date.available2021-06-17T13:56:03Z
dc.date.issued2021
dc.description.abstractFew studies have reported the prognosis of human immunodeficiency virus (HIV)-positive patients followed for a long time in Brazil, particularly those including pre and post-HAART eras. The polymorphisms of interferon (IFN)-lambda 4 have been postulated as possibly associated with the pathogenesis of HIV infection. The aim of this study was to describe the incidence and mortality from a cohort of HIV-positive patients as well as whether IFN-lambda 4 gene polymorphisms (SNP rs8099917 and SNP rs12979860) were associated with HIV/acquired immune deficiency syndrome (AIDS) progression. We followed 402 patients for up to 30 years; 347 of them began follow-up asymptomatic, without any AIDS-defining opportunistic disease and/or a lymphocytes T CD4+ count of 350 cells/mm(3)or lower. We determined the probability of the asymptomatic subjects to remain AIDS-free, and the risk of death for those entering the study already with an AIDS diagnosis, as well as for subjects developing AIDS during follow-up. We compared the prognosis of patients with two different polymorphisms for the genes encoding for IFN-lambda 4, variants rs8099917 and rs12979860. The follow-up time of the 347 asymptomatic-at-entry subjects was 3687 person-years. IFN-lambda 4 rs8099917 polymorphisms were not associated with AIDS progression, but IFN-lambda 4 rs12979860 wild type genotype (CC) was associated with higher mortality compared to CT and TT, with an increased probability of death from AIDS (P = .01). In conclusion, genetic variations in IFN-lambda 4 on rs12979860 polymorphisms in HIV-infected patients may drive mortality risk.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2017/08320-5, 2018/07239-2, 2016/03025-2, 2019/18522-0]
dc.description.sponsorshipCNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [301372/2013-6]
dc.identifier.citationJOURNAL OF MEDICAL VIROLOGY, v.93, n.6, p.3601-3606, 2021
dc.identifier.doi10.1002/jmv.26054
dc.identifier.eissn1096-9071
dc.identifier.issn0146-6615
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40851
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Medical Virology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectHIV-1eng
dc.subjectIFN-lambda 4eng
dc.subjectSNPeng
dc.subjectviral loadeng
dc.subject.othergenetic-variationeng
dc.subject.otherspontaneous clearanceeng
dc.subject.otheril28beng
dc.subject.othergenotypeeng
dc.subject.wosVirologyeng
dc.titleAIDS incidence and survival in a hospital-based cohort of HIV-positive patients from Sao Paulo, Brazil: The role of IFN-lambda 4 polymorphismseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalVEIGA, Ana Paula R.:Univ Sao Paulo, Fac Med FMUSP, Hosp Clin, Dept Dermatol,Ambulatorio Dermatol & Imunodeficie, Rua Dr Eneas Carvalho Aguiar 500, BR-05403000 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcGABRIELA DA SILVA PRATES
hcfmusp.contributor.author-fmusphcFERNANDA DE MELLO MALTA
hcfmusp.contributor.author-fmusphcFERNANDA DE TOLEDO GONCALVES
hcfmusp.contributor.author-fmusphcMARIANA AMELIA MONTEIRO
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO MARCONDES FONSECA
hcfmusp.contributor.author-fmusphcMARCELLO MIHAILENKO CHAVES MAGRI
hcfmusp.contributor.author-fmusphcALBERTO JOSE DA SILVA DUARTE
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.contributor.author-fmusphcTATIANE ASSONE CASSEB
hcfmusp.description.beginpage3601
hcfmusp.description.endpage3606
hcfmusp.description.issue6
hcfmusp.description.volume93
hcfmusp.origemWOS
hcfmusp.origem.pubmed32449798
hcfmusp.origem.scopus2-s2.0-85097864756
hcfmusp.origem.wosWOS:000576546300001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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