An outbreak of invasive fusariosis in a children's cancer hospital

Imagem de Miniatura
Arquivos
art_LITVINOV_An_outbreak_of_invasive_fusariosis_in_a_childrens_2015.PDF (442.15 KB)
Citações na Scopus
49
Tipo de produção
article
Data de publicação
2015
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Autores
Citação
CLINICAL MICROBIOLOGY AND INFECTION, v.21, n.3, 2015
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Fusarium is considered an emerging pathogen, and there are few reports of fusariosis in children. The objective of this study was to describe an outbreak of invasive fusariosis in a children's cancer hospital. A neutropenic 17-year-old male patient hospitalized for 10 days for a relapse of acute myeloid leukaemia, under chemotherapy, presented fever without any other symptoms; a thoracic computerized tomography showed bilateral pulmonary nodules. During voriconazole treatment, 1-cm reddened and painful subcutaneous nodules appeared on arms and legs and the culture of a skin biopsy revealed F. solani. Another case occurred 11 days later and started an outbreak investigation. Water samples for cultures were collected from taps, showers and water reservoirs. Air from all patient rooms was sampled. Faucets and the drains of sinks and showers were swabbed and cultured. Environmental and clinical isolates were typed. There were 10 confirmed cases of infection caused by Fusarium spp. F. oxysporum and F. solani were isolated from water, swabs and air in patient rooms. Many control measures were instituted, but the outbreak was only controlled 1 year after the first case, when water filters filtering 0.2 mu m were installed at the exit of all faucets and showers in all patient rooms (points-of-use). Typing demonstrated that clinical isolates of F. oxysporum were similar to those of the environment. In conclusion, to our knowledge this is the first reported outbreak of invasive fusariosis in children with oncohaematologic disease. It was controlled using 0.2-mu m filters in all tap faucets and showers. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases.
Palavras-chave
Fusarium infection, oncohaematologic disease, paediatric infections, water filter, water
URI
https://observatorio.fm.usp.br/handle/OPI/12758
Referências
  1. Boutati EI, 1997, BLOOD, V90, P999
  2. Nucci M, 2003, CANCER, V98, P315, DOI 10.1002/cncr.11510
  3. NELSON PE, 1994, CLIN MICROBIOL REV, V7, P479
  4. TAMURA K, 1993, MOL BIOL EVOL, V10, P512
  5. Nucci M, 2007, CLIN MICROBIOL REV, V20, P695, DOI 10.1128/CMR.00014-07
  6. Chehri K, 2014, MICROB PATHOGENESIS, V67-68, P14, DOI 10.1016/j.micpath.2014.01.002
  7. Oliveira MS, 2007, J HOSP INFECT, V66, P327, DOI 10.1016/j.jhin.2007.04.020
  8. Warris A, 2001, J HOSP INFECT, V47, P143, DOI 10.1053/jhin.2000.0876
  9. Cakir M, 2009, CURR EYE RES, V34, P988, DOI 10.3109/02713680903254822
  10. Perfect JR, 2003, CLIN INFECT DIS, V36, P1122, DOI 10.1086/374557
  11. Lin YE, 2011, INFECT CONT HOSP EP, V32, P166, DOI 10.1086/657934
  12. Ortolano GA, 2005, AM J INFECT CONTROL, V33, pS1, DOI 10.1016/j.ajic.2005.03.014
  13. Bullock JD, 2010, OPHTHAL EPIDEMIOL, V17, P179, DOI 10.3109/09286581003749975
  14. Schaffer K, 2008, J HOSP INFECT, V69, P400, DOI 10.1016/j.jhin.2008.03.008
  15. Nucci M, 2013, EMERG INFECT DIS, V19, P1567, DOI 10.3201/eid1910.120847
  16. Anaissie EJ, 2001, CLIN INFECT DIS, V33, P1871, DOI 10.1086/324501
  17. Tortorano AM, 2014, CLIN MICROBIOL INFEC, V20, P27, DOI 10.1111/1469-0691.12465
  18. Morris SK, 2012, CAN J INFECT DIS MED, V23, P179
  19. Tamura K, 2013, MOL BIOL EVOL, V30, P2725, DOI 10.1093/molbev/mst197
  20. VISCOLI C, 1990, EUR J CLIN MICROBIOL, V9, P773, DOI 10.1007/BF02184694
  21. Guarro J, 2013, EUR J CLIN MICROBIOL, V32, P1491, DOI 10.1007/s10096-013-1924-7
  22. Warris A, 2010, J HOSP INFECT, V76, P56, DOI 10.1016/j.jhin.2010.03.014
  23. Sautour M, 2012, INT J HYG ENVIR HEAL, V215, P286, DOI 10.1016/j.ijheh.2011.11.003
  24. Patel A, 2008, CURR OPIN OPHTHALMOL, V19, P302, DOI 10.1097/ICU.0b013e3283045e74
  25. O'Donnell K, 1998, P NATL ACAD SCI USA, V95, P2044, DOI 10.1073/pnas.95.5.2044
  26. Exner M, 2005, AM J INFECT CONTROL, V33, pS26, DOI 10.1016/j.ajic.2005.04.002
  27. Gungel H, 2011, MYCOSES, V54, P767
  28. Hosein IK, 2005, J HOSP INFECT, V61, P100, DOI 10.1016/j.jhin.2005.02.008
  29. Mesquita-Rocha S, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-289
  30. Ridell RW, 1950, MYCOLOGIA, V42, P265
  31. Scheel CM, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-49
  32. Schwartz KL, 2013, J PEDIAT INFECT DIS, P1
  33. Silva F. P. D., 2014, TROP PLANT PATHOL, V39, P64
  34. Vagace JM, 2007, BMC INFECT DIS, V7, DOI 10.1186/1471-2334-7-40
  35. Wattier RL, 2014, J PEDIAT INFECT DIS, P1

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/36
Artigos e Materiais de Revistas Científicas - LIM/53
Artigos e Materiais de Revistas Científicas - LIM/54
Carregar mais