Pancreatitis Subtypes Survey in 852 Childhood-Onset Systemic Lupus Erythematosus Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARQUES, Victor L. S.
dc.contributor.authorGORMEZANO, Natali W. S.
dc.contributor.authorBONFA, Eloisa
dc.contributor.authorAIKAWA, Nadia E.
dc.contributor.authorTERRERI, Maria T.
dc.contributor.authorPEREIRA, Rosa M.
dc.contributor.authorMAGALHAES, Claudia S.
dc.contributor.authorGUARIENTO, Andressa
dc.contributor.authorAPPENZELLER, Simone
dc.contributor.authorFERRIANI, Virginia P.
dc.contributor.authorBARBOSA, Cassia M.
dc.contributor.authorRAMOS, Valeria C.
dc.contributor.authorLOTUFO, Simone
dc.contributor.authorSILVA, Clovis A.
dc.date.accessioned2016-03-14T14:22:01Z
dc.date.available2016-03-14T14:22:01Z
dc.date.issued2016
dc.description.abstractObjective:Pancreatitis is a rare and a life-threatening systemic lupus erythematosus (SLE) manifestation in childhood-onset SLE (cSLE). The objective of this study was to systematically classify pancreatitis in cSLE according to the International Study Group of Pediatric Pancreatitis and determine the overall prevalence, clinical features, laboratory, and first episode outcomes.Methods:A multicenter cohort study in 10 pediatric rheumatology centers, including 852 patients with cSLE.Results:Pancreatitis was diagnosed in 22 of 852 (2.6%) patients with cSLE. It was classified as acute pancreatitis in 20 (91%), acute recurrent pancreatitis in 2 (9%), and none of them had chronic pancreatitis. None of them had gallstones, traumatic pancreatitis, or reported alcohol/tobacco use. The comparison of patients with pancreatitis (first episode) and without this complication revealed a shorter disease duration (1 [0-10] vs 4 [0-23] years, P<0.0001) and higher median of Systemic Lupus Erythematosus Disease Activity Index 2000 (21 [0-41] vs 2 [0-45], P<0.0001). The frequencies of fever (P<0.0001), weight loss (P<0.0001), serositis (P<0.0001), nephritis (P<0.0001), arterial hypertension (P<0.0001), acute renal failure (P<0.0001), macrophage activation syndrome (P<0.0001), and death (P=0.001) were also higher in patients with pancreatitis. The frequencies of intravenous methylprednisolone use (P<0.0001) and the median of prednisone dose (55 [15-60] vs 11 [1-90] mg/day, P<0.0001) were significantly higher in patients with pancreatitis. Of note, the 2 patients with acute recurrent pancreatitis had 2 episodes, with pain-free interval of 1 and 4 years.Conclusions:This was the first study characterizing pancreatitis using the International Study Group of Pediatric Pancreatitis standardized definitions in patients with cSLE showing that the predominant form is acute pancreatitis seen in association with glucocorticoid treatment and active severe disease.
dc.description.indexMEDLINE
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 2009/51897-5, 301805/2013-0, 302724/2011-7]
dc.description.sponsorshipFederico Foundation
dc.description.sponsorshipNucleo de Apoio a Pesquisa ""Saude da Crianca e do Adolescente"" da USP (NAP-CriAd)
dc.identifier.citationJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, v.62, n.2, p.328-334, 2016
dc.identifier.doi10.1097/MPG.0000000000000990
dc.identifier.eissn1536-4801
dc.identifier.issn0277-2116
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13405
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofJournal of Pediatric Gastroenterology and Nutrition
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectchildhood-onset systemic lupus erythematosus
dc.subjectglucocorticoid
dc.subjectpancreatitis
dc.subjectSystemic Lupus Erythematosus Disease Activity Index
dc.subject.otherpediatric acute-pancreatitis
dc.subject.otherof-the-literature
dc.subject.othercase series
dc.subject.othercriteria
dc.subject.otherchildren
dc.subject.otherupdate
dc.subject.otherindex
dc.subject.otherclassification
dc.subject.otherseverity
dc.subject.otherlipase
dc.subject.wosGastroenterology & Hepatology
dc.subject.wosNutrition & Dietetics
dc.subject.wosPediatrics
dc.titlePancreatitis Subtypes Survey in 852 Childhood-Onset Systemic Lupus Erythematosus Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalTERRERI, Maria T.:Univ Fed Sao Paulo, Pediat Rheumatol Unit, Sao Paulo, Brazil
hcfmusp.author.externalMAGALHAES, Claudia S.:Sao Paulo State Univ, UNESP, Fac Med Botucatu, Sao Paulo, Brazil
hcfmusp.author.externalGUARIENTO, Andressa:Irmandade Santa Casa de Misericordia Sao Paulo, Sao Paulo, Brazil
hcfmusp.author.externalAPPENZELLER, Simone:Univ Estadual Campinas, Sao Paulo, Brazil
hcfmusp.author.externalFERRIANI, Virginia P.:Univ Sao Paulo, Ribeirao Preto Med Sch, BR-05403000 Sao Paulo, SP, Brazil
hcfmusp.author.externalBARBOSA, Cassia M.:Hosp Infantil Darcy Vargas, Sao Paulo, Brazil
hcfmusp.author.externalRAMOS, Valeria C.:Pontifical Catholic Univ Sorocaba, Sao Paulo, Brazil
hcfmusp.author.externalLOTUFO, Simone:Hosp Municipal Infantil Menino Jesus, Sao Paulo, Brazil
hcfmusp.citation.scopus24
hcfmusp.contributor.author-fmusphcVICTOR LEONARDO SARAIVA MARQUES
hcfmusp.contributor.author-fmusphcNATALI WENIGER SPELLING GORMEZANO
hcfmusp.contributor.author-fmusphcELOISA SILVA DUTRA DE OLIVEIRA BONFA
hcfmusp.contributor.author-fmusphcNADIA EMI AIKAWA
hcfmusp.contributor.author-fmusphcROSA MARIA RODRIGUES PEREIRA
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.description.beginpage328
hcfmusp.description.endpage334
hcfmusp.description.issue2
hcfmusp.description.volume62
hcfmusp.origemWOS
hcfmusp.origem.pubmed26418213
hcfmusp.origem.scopus2-s2.0-84956892606
hcfmusp.origem.wosWOS:000369292300011
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-04-12
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