M2-Polarized Macrophages Determine Human Cutaneous Lesions in Lacaziosis

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Arquivos
art_BARBOZA_M2Polarized_Macrophages_Determine_Human_Cutaneous_Lesions_in_Lacaziosis_2020.PDF.pdf (795.7 KB)
Citações na Scopus
4
Tipo de produção
article
Data de publicação
2020
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER
Autores
BARBOZA, Tania Cristina
BRITO, Arival Cardoso de
QUARESMA, Juarez Antonio Simoes
Citação
MYCOPATHOLOGIA, v.185, n.3, p.477-483, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Lacaziosis is a cutaneous chronic mycosis caused by Lacazia loboi. Macrophages are important cells in the host immune response in fungal infections. The macrophage population exhibits strong plasticity that varies according to the stimuli in the microenvironment of lesions M1 profile promotes a Th1 pattern of cytokines and a microbicidal function and M2 is related to Th2 cytokines and immunomodulatory response. We investigated the population of M1 and M2 polarized macrophages in human cutaneous lesions. A total of 27 biopsies from human lesions were submitted to an immunohistochemistry protocol using antibodies to detect M1 and M2 macrophages (Arginase-1, CD163, iNOS, RBP-J and cMAF). We could observe high number of cells expressing Arginase1, CD163 and c-MAF that correspond to elements of the M2 profile of macrophage, over iNOS and RBP-J (elements of the M1 profile). The results suggest a predominant phenotype of M2 macrophages, which have an immunomodulatory role and probably contributing to chronicity of Lacaziosis.
Palavras-chave
Lacaziosis, M1 macrophages, M2 macrophages, Immunopathogenesis
URI
https://observatorio.fm.usp.br/handle/OPI/37022
Referências
  1. Ambarus CA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035994
  2. Avdic S, 2013, J VIROL, V87, P10273, DOI 10.1128/JVI.00912-13
  3. Barboza TC, 2015, MYCOPATHOLOGIA, V179, P269, DOI 10.1007/s11046-014-9836-3
  4. Barros MHM, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0080908
  5. Benoit M, 2008, J IMMUNOL, V181, P3733, DOI 10.4049/jimmunol.181.6.3733
  6. Brito Arival Cardoso de, 2007, An. Bras. Dermatol., V82, P461, DOI 10.1590/S0365-05962007000500010
  7. Cassetta L, 2013, AIDS, V27, P1847, DOI 10.1097/QAD.0b013e328361d059
  8. Cassol E, 2013, AIDS, V27, P707, DOI 10.1097/QAD.0b013e32835cfc82
  9. Chacon-Salinas R, 2005, CLIN EXP IMMUNOL, V140, P443, DOI 10.1111/j.1365-2249.2005.02797.x
  10. Franks TJ, 2003, HUM PATHOL, V34, P743, DOI 10.1016/S0046-8177(03)00367-8
  11. FUCHS J, 1990, CUTIS, V46, P227
  12. Gordon S, 2010, IMMUNITY, V32, P593, DOI 10.1016/j.immuni.2010.05.007
  13. Herr RA, 2001, J CLIN MICROBIOL, V39, P309, DOI 10.1128/JCM.39.1.309-314.2001
  14. Kiszewski AE, 2006, CLIN EXP IMMUNOL, V143, P445, DOI 10.1111/j.1365-2249.2006.03020.x
  15. Kong LQ, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0059771
  16. Lacaz CS, 1986, DOENCA J LOBO
  17. Lavanchy D, 2011, CLIN MICROBIOL INFEC, V17, P107, DOI 10.1111/j.1469-0691.2010.03432.x
  18. Leite JM, 1967, AT S BIOT AM PAT, V6, pLeite
  19. Lobo J, 1931, REV MED PERNAMBUCO, V1, P763
  20. Martinez Fernando O, 2014, F1000Prime Rep, V6, P13, DOI 10.12703/P6-13
  21. Michalany J, 1995, REV ASSOC MED BRAS, V2, P61
  22. Movahedi K, 2010, CANCER RES, V70, P5728, DOI 10.1158/0008-5472.CAN-09-4672
  23. Opromolla D. V. A., 2000, Anais Brasileiros de Dermatologia, V75, P425
  24. Opromolla D. V. A., 1999, Anais Brasileiros de Dermatologia, V74, P135
  25. Opromolla D. V. A., 1999, Anais Brasileiros de Dermatologia, V74, P345
  26. Opromolla DVA, 2005, DINAMICA DOENCAS INF, P1185
  27. Puig-Kroger A, 2009, CANCER RES, V69, P9395, DOI 10.1158/0008-5472.CAN-09-2050
  28. Rottenberg ME, 2002, CURR OPIN IMMUNOL, V14, P444, DOI 10.1016/S0952-7915(02)00361-8
  29. Shaughnessy LM, 2007, FRONT BIOSCI-LANDMRK, V12, P2683, DOI 10.2741/2364
  30. Sica A, 2012, J CLIN INVEST, V122, P787, DOI 10.1172/JCI59643
  31. Silva D., 1996, Anais Brasileiros de Dermatologia, V71, P211
  32. Silva D, 1972, REV SOC BRAS MED TRO, V6, P85, DOI [10.1590/S0037-86821972000200005, DOI 10.1590/S0037-86821972000200005]
  33. Taborda PR, 1999, J CLIN MICROBIOL, V37, P2031, DOI 10.1128/JCM.37.6.2031-2033.1999
  34. Vilani-Moreno FR, 2011, MED MYCOL, V49, P643, DOI 10.3109/13693786.2010.547993
  35. Wang HH, 2014, BIOCHEM BIOPH RES CO, V454, P71, DOI 10.1016/j.bbrc.2014.10.023
  36. Xavier MB, 2008, HUM PATHOL, V39, P269, DOI 10.1016/j.humpath.2007.06.016
  37. Xu HX, 2012, NAT IMMUNOL, V13, P642, DOI 10.1038/ni.2304
  38. Zaba LC, 2007, J CLIN INVEST, V117, P2517, DOI 10.1172/JCI32282

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - LIM/53
Artigos e Materiais de Revistas Científicas - ODS/03