Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNUNES, Valeria Sutti
dc.contributor.authorCAZITA, Patricia Miralda
dc.contributor.authorCATANOZI, Sergio
dc.contributor.authorNAKANDAKARE, Edna Regina
dc.contributor.authorQUINTAO, Eder Carlos Rocha
dc.date.accessioned2018-09-13T15:22:29Z
dc.date.available2018-09-13T15:22:29Z
dc.date.issued2018
dc.description.abstractApolipoprotein E knockout (apoE-KO) mice present synaptic loss, cognitive dysfunction, and high plasma lipid levels that may affect brain function simulating Alzheimer disease. Plasma and brain sterols were measured in apoE-KO and in wild type control mice on a cholesterol-free, phytosterol-containing diet by gas chromatography coupled to a mass spectrometer. Plasma cholesterol and phytosterols (campesterol and sitosterol) were higher in apoE-KO compared to control mice. Cholesterol precursors (desmosterol and lathosterol) were not detected in plasma of control mice but were present in apoE-KO mice. In the brain amounts of cholesterol, desmosterol, campesterol and 24-hydroxycholesterol were significantly lower in apoE-KO than in controls. There is a tendency in apoE-KO for lower values of 7 alpha-hydroxycholesterol and 7 beta-hydroxycholesterol. Cholesterol content, synthesis rates (desmosterol) and export of 24-hydroxycholesterol are reduced in the brain of the severe hypercholesterolemic apoE-KO mice.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP), Sao Paulo, Brazil [2015-17566-2]
dc.identifier.citationJOURNAL OF BIOENERGETICS AND BIOMEMBRANES, v.50, n.4, p.283-287, 2018
dc.identifier.doi10.1007/s10863-018-9757-9
dc.identifier.eissn1573-6881
dc.identifier.issn0145-479X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/27972
dc.language.isoeng
dc.publisherSPRINGER/PLENUM PUBLISHERS
dc.relation.ispartofJournal of Bioenergetics and Biomembranes
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER/PLENUM PUBLISHERS
dc.subjectApolipoprotein E knockout mice
dc.subjectSterols
dc.subjectPhytosterols
dc.subjectOxysterols
dc.subjectBrain
dc.subject.othercentral-nervous-system
dc.subject.othere-deficient mice
dc.subject.otherapolipoprotein-e
dc.subject.othercognitive impairment
dc.subject.otheralzheimers-disease
dc.subject.othermetabolism
dc.subject.othermouse
dc.subject.other24s-hydroxycholesterol
dc.subject.otherbeta
dc.subject.otherhypercholesterolemia
dc.subject.wosBiophysics
dc.subject.wosCell Biology
dc.titleDecreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus23
hcfmusp.contributor.author-fmusphcVALERIA SUTTI NUNES
hcfmusp.contributor.author-fmusphcPATRICIA MIRALDA CAZITA
hcfmusp.contributor.author-fmusphcSERGIO CATANOZI
hcfmusp.contributor.author-fmusphcEDNA REGINA NAKANDAKARE
hcfmusp.contributor.author-fmusphcEDER CARLOS ROCHA QUINTAO
hcfmusp.description.beginpage283
hcfmusp.description.endpage287
hcfmusp.description.issue4
hcfmusp.description.volume50
hcfmusp.origemWOS
hcfmusp.origem.pubmed29675736
hcfmusp.origem.scopus2-s2.0-85045727052
hcfmusp.origem.wosWOS:000435587700003
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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