Neurohumoral and Endothelial Responses to Heated Water-Based Exercise in Resistant Hypertensive Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCRUZ, Lais Galvani de Barros
dc.contributor.authorBOCCHI, Edimar Alcides
dc.contributor.authorGRASSI, Guido
dc.contributor.authorGUIMARAES, Guilherme Veiga
dc.date.accessioned2017-06-09T15:31:33Z
dc.date.available2017-06-09T15:31:33Z
dc.date.issued2017
dc.description.abstractBackground: The neurohumoral and endothelial responses to the blood pressure (BP) lowering effects of heated water- based exercise (HEx) in resistant hypertension (HT) patients remain undefined. Methods and Results: We investigated these in 44 true resistant HT patients (age 53.3 +/- 0.9 years, mean +/- SEM). They were randomized and allocated to 2 groups, 28 to a HEx training protocol, which consisted of callisthenic exercises and walking in a heated pool for 1 h, three times weekly for 12 weeks and 16 patients to a control group maintaining their habitual activities. Measurements made before and after 12 weeks of HEx included clinic and 24-h BP, plasma levels of nitric oxide, endothelin- 1, aldosterone, renin, norepinephrine and epinephrine, as well as peak V. O2, and endothelial function (reactive hyperemia). After 12 weeks of HEx patients showed a significant decrease in clinic and 24- h systolic and diastolic BPs. Concomitantly, nitric oxide increased significantly (from 25 +/- 8 to 75 +/- 24 mu mol/ L, P < 0.01), while endothelin-1 (from 41 +/- 5 to 26 +/- 3 pg/ mL), renin (from 35 +/- 4 to 3.4 +/- 1 ng/mL/h), and norepinephrine (from 720 +/- 54 to 306 +/- 35 pg/ mL) decreased significantly (P < 0.01). Plasma aldosterone also tended to decrease, although not significantly (from 101 +/- 9 to 76 +/- 4 pg/ mL, P=NS). Peak VO2 increased significantly after HEx (P < 0.01), while endothelial function was unchanged. No significant change was detected in the control group. Conclusions: The BP-lowering effects of HEx in resistant HT patients were accompanied by a significant reduction in the marked neurohumoral activation characterizing this clinical condition.
dc.description.indexMEDLINE
dc.identifier.citationCIRCULATION JOURNAL, v.81, n.3, p.339-345, 2017
dc.identifier.doi10.1253/circj.CJ-16-0870
dc.identifier.eissn1347-4820
dc.identifier.issn1346-9843
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/19997
dc.language.isoeng
dc.publisherJAPANESE CIRCULATION SOC
dc.relation.ispartofCirculation Journal
dc.rightsrestrictedAccess
dc.rights.holderCopyright JAPANESE CIRCULATION SOC
dc.subjectEndothelial dysfunction
dc.subjectHeated water-based exercise
dc.subjectNeurohumoral activation
dc.subjectResistant hypertension
dc.subject.otherangiotensin-aldosterone system
dc.subject.otherleft-ventricular hypertrophy
dc.subject.otherheart-failure patients
dc.subject.otherblood-pressure
dc.subject.othercontrolled-trial
dc.subject.otherplasma
dc.subject.otherdysfunction
dc.subject.otherstiffness
dc.subject.otherhumans
dc.subject.otherassay
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleNeurohumoral and Endothelial Responses to Heated Water-Based Exercise in Resistant Hypertensive Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryItália
hcfmusp.affiliation.countryisoit
hcfmusp.author.externalGRASSI, Guido:Univ Milano Bicocca, IRCCS Multimed, Dept Med & Surg, Milan, Italy
hcfmusp.citation.scopus26
hcfmusp.contributor.author-fmusphcLAIS GALVANI DE BARROS CRUZ
hcfmusp.contributor.author-fmusphcEDIMAR ALCIDES BOCCHI
hcfmusp.contributor.author-fmusphcGUILHERME VEIGA GUIMARAES
hcfmusp.description.beginpage339
hcfmusp.description.endpage345
hcfmusp.description.issue3
hcfmusp.description.volume81
hcfmusp.origemWOS
hcfmusp.origem.pubmed28049937
hcfmusp.origem.scopus2-s2.0-85013901896
hcfmusp.origem.wosWOS:000395054400011
hcfmusp.publisher.cityTOYKO
hcfmusp.publisher.countryJAPAN
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