Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPOLACHINI, Giovana Mussi
dc.contributor.authorCASTRO, Tialfi Bergamin de
dc.contributor.authorSMARRA, Luis Fabiano Soares
dc.contributor.authorHENRIQUE, Tiago
dc.contributor.authorPAULA, Carlos Henrique Diniz de
dc.contributor.authorSEVERINO, Patricia
dc.contributor.authorLOPEZ, Rossana Veronica Mendoza
dc.contributor.authorCARVALHO, Andre Lopes
dc.contributor.authorZERI, Ana Carolina de Mattos
dc.contributor.authorSILVA, Ismael Dale Cotrim Guerreiro
dc.contributor.authorTAJARA, Eloiza H.
dc.date.accessioned2024-04-05T19:38:44Z
dc.date.available2024-04-05T19:38:44Z
dc.date.issued2023
dc.description.abstractMetabolomics has proven to be an important omics approach to understand the molecular pathways underlying the tumour phenotype and to identify new clinically useful markers. The literature on cancer has illustrated the potential of this approach as a diagnostic and prognostic tool. The present study aimed to analyse the plasma metabolic profile of patients with oral squamous cell carcinoma (OSCC) and controls and to compare patients with metastatic and primary tumours at different stages and subsites using nuclear magnetic resonance and mass spectrometry. To our knowledge, this is the only report that compared patients at different stages and subsites and replicates collected in diverse institutions at different times using these methodologies. Our results showed a plasma metabolic OSCC profile suggestive of abnormal ketogenesis, lipogenesis and energy metabolism, which is already present in early phases but is more evident in advanced stages of the disease. Reduced levels of several metabolites were also associated with an unfavorable prognosis. The observed metabolomic alterations may contribute to inflammation, immune response inhibition and tumour growth, and may be explained by four nonexclusive views-differential synthesis, uptake, release, and degradation of metabolites. The interpretation that assimilates these views is the cross talk between neoplastic and normal cells in the tumour microenvironment or in more distant anatomical sites, connected by biofluids, signalling molecules and vesicles. Additional population samples to evaluate the details of these molecular processes may lead to the discovery of new biomarkers and novel strategies for OSCC prevention and treatment.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipConselho Nacional de Pesquisas/CNPq (CNPq) [10/51168-0/EHT, 2011/23353-0/GMP, 2019/07293-0/TBC, 2021/07087-0/TBC, 2021/03647-1/CHDP]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo/FAPESP (FAPESP) [10/51168-0/EHT, 2011/23353-0/GMP, 2019/07293-0/TBC, 2021/07087-0/TBC, 2021/03647-1/CHDP]
dc.description.sponsorshipConselho Nacional de Pesquisas/CNPq (CNPq) [306216/2010-8/EHT, 308904/2014-1/EHT, 307327/2018-3/EHT]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior/CAPES (CAPES-USP)
dc.identifier.citationSCIENTIFIC REPORTS, v.13, n.1, article ID 8588, 21p, 2023
dc.identifier.doi10.1038/s41598-023-34808-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/59128
dc.language.isoeng
dc.publisherNATURE PORTFOLIOeng
dc.relation.ispartofScientific Reports
dc.rightsopenAccesseng
dc.rights.holderCopyright NATURE PORTFOLIOeng
dc.subject.otherneck-cancereng
dc.subject.othersphingolipid metabolismeng
dc.subject.otherbeta-hydroxybutyrateeng
dc.subject.othercholine metaboliteseng
dc.subject.otheroxidative stresseng
dc.subject.otherprostate-cancereng
dc.subject.otherbreast-cancereng
dc.subject.otherheadeng
dc.subject.otherh-1eng
dc.subject.otherserumeng
dc.subject.wosMultidisciplinary Scienceseng
dc.titlePlasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival predictioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalPOLACHINI, Giovana Mussi:Sch Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalCASTRO, Tialfi Bergamin de:Sch Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalSMARRA, Luis Fabiano Soares:Sch Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil; Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, SP, Brazil
hcfmusp.author.externalHENRIQUE, Tiago:Sch Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalPAULA, Carlos Henrique Diniz de:Sch Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalSEVERINO, Patricia:Hosp Israelita Albert Einstein, Albert Einstein Res & Educ Inst, Sao Paulo, SP, Brazil
hcfmusp.author.externalCARVALHO, Andre Lopes:Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, SP, Brazil
hcfmusp.author.externalZERI, Ana Carolina de Mattos:Brazilian Ctr Res Energy & Mat CNPEM, Ilum Sch Sci, Campinas, SP, Brazil
hcfmusp.author.externalSILVA, Ismael Dale Cotrim Guerreiro:Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, SP, Brazil; Fleury Labs, Sao Paulo, SP, Brazil
hcfmusp.author.externalTAJARA, Eloiza H.:Sch Med Sao Jose Do Rio Preto FAMERP, Dept Mol Biol, Av Brigadeiro Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP, Brazil; Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus3
hcfmusp.contributor.author-fmusphcROSSANA VERONICA MENDOZA LOPEZ
hcfmusp.description.articlenumber8588
hcfmusp.description.issue1
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1158395393
hcfmusp.origem.pubmed37237049
hcfmusp.origem.scopus2-s2.0-85160373455
hcfmusp.origem.wosWOS:001001070500045
hcfmusp.publisher.cityBERLINeng
hcfmusp.publisher.countryGERMANYeng
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