Impact of Pediatric Hematopoietic Stem-Cell Transplantation on Craniofacial Growth

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Arquivos
art_FRASCINO_Impact_of_Pediatric_Hematopoietic_StemCell_Transplantation_on_Craniofacial_2020.PDF.pdf (424.15 KB)
Citações na Scopus
0
Tipo de produção
article
Data de publicação
2020
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HOSPITAL CLINICAS, UNIV SAO PAULO
Autores
FAVA, Marcelo
Citação
CLINICS, v.75, article ID e1901, 6p, 2020
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
OBJECTIVES: To assess the craniofacial skeletal growth in pediatric hematopoietic stem-cell transplantation (HSCT) survivors in comparison with age-sex matched-paired controls. METHODS: A case-controlled retrospective comparison of the craniofacial growth in 25 HSCT children and 25 matched-paired controls was conducted. Craniofacial growth was quantitatively assessed by linear and angular measurements in panoramic radiographic images using ImageJ (R). Stature growth and body weight were obtained through physical examination. Cancer diagnosis, myeloablative conditioning, and HSCT were retrieved from medical records. RESULTS: Patients aged 12.2 years (+/- 3.8; 16 male, 9 female). Radiographic images were obtained on an average of 2.43 (+/- 2.0) years after HSCT. The main malignant diagnosis was acute lymphoblastic leukemia (56%), followed by acute myeloid leukemia (36%) and myelodysplastic syndromes (8%). Total body irradiation was associated with chemotherapy at 80%. Mean age at transplantation was 10 (+/- 4.7) years. HSCT survivors showed reduced a vertical growth of the mandibular ramus (p.O.003). This persisted among individuals below 12 years of age (p=0.017). The HSCT group showed delayed dental eruption, though there was no statistically significant difference (p=0.3668). The HSCT group showed stature deficit, increased weight, and body mass index (Z-score stature: -0.28; Z-score weight: 0.38, respectively). CONCLUSIONS: Pediatric HSCT has decreased vertical craniofacial growth compared to their matched controls. There might be an association between reduced craniofacial vertical growth and reduced estature growth. Further studies to quantitatively investigate the impact of different myeloablative regimens in craniofacial skeletal growth and development.
Palavras-chave
Hematopoietic Stem-Cell Transplantation, Pediatrics, Bone Marrow Transplantation, Skull/Growth and Development, Facial Bones/Growth and Development
URI
https://observatorio.fm.usp.br/handle/OPI/38422
Referências
  1. Al-Jewair Thikriat S., 2018, Dental Press J. Orthod., V23, P37, DOI 10.1590/2177-6709.23.2.037-045.oar
  2. Calvo-Henriquez C, 2019, INT J PEDIATR OTORHI, V119, P161, DOI 10.1016/j.ijporl.2019.01.035
  3. D'Souza A, 2017, BIOL BLOOD MARROW TR, V23, P1417, DOI 10.1016/j.bbmt.2017.05.035
  4. Frascino AV, 2019, CLINICS, V74, DOI 10.6061/clinics/2019/e929
  5. Frascino AV, 2014, CLIN LAB RES DEN, V20, P252, DOI [10.11606/issn.2357-8041.clrd.2014.84385, DOI 10.11606/ISSN.2357-8041.CLRD.2014.84385]
  6. Frascino AV, 2016, REV CPAQV, V8, P1
  7. Gawade PL, 2014, CURR PEDIATR REV, V10, P249, DOI 10.2174/1573400510666141114223827
  8. Gratwohl A, 2015, LANCET HAEMATOL, V2, pE91, DOI 10.1016/S2352-3026(15)00028-9
  9. Gratwohl A, 2010, JAMA-J AM MED ASSOC, V303, P1617, DOI 10.1001/jama.2010.491
  10. Gurney JG, 2014, PEDIATR BLOOD CANCER, V61, P1270, DOI 10.1002/pbc.25010
  11. Huang YS, 2019, SLEEP MED, V60, P20, DOI 10.1016/j.sleep.2018.10.015
  12. Lemos Alexandre Durval, 2014, Dental Press J. Orthod., V19, P52, DOI 10.1590/2176-9451.19.3.052-058.oar
  13. Maber M, 2006, FORENSIC SCI INT, V159, pS68, DOI 10.1016/j.forsciint.2006.02.019
  14. Nakagawa R, 2018, ENDOCRINE, V61, P76, DOI 10.1007/s12020-018-1595-3
  15. Nishimura S, 2013, EUR J CANCER CARE, V22, P353, DOI 10.1111/ecc.12038
  16. Passweg JR, 2013, BONE MARROW TRANSPL, V48, P1161, DOI 10.1038/bmt.2013.51
  17. Rodriguez-Galindo C, 2015, J CLIN ONCOL, V33, P3065, DOI 10.1200/JCO.2014.60.6376
  18. Ruyssinck L, 2019, BIOL BLOOD MARROW TR, V25, P107, DOI 10.1016/j.bbmt.2018.08.027
  19. Sanders JE, 2008, BONE MARROW TRANSPL, V41, P223, DOI 10.1038/sj.bmt.1705875
  20. Shenoy S, 2017, BIOL BLOOD MARROW TR, V23, P552, DOI 10.1016/j.bbmt.2017.01.009
  21. Skinner R, 2006, LANCET ONCOL, V7, P489, DOI 10.1016/S1470-2045(06)70724-0
  22. Sun CL, 2010, BLOOD, V116, P3129, DOI 10.1182/blood-2009-06-229369
  23. Tanzi EM, 2011, J PEDIATR ONCOL NURS, V28, P191, DOI 10.1177/1043454211408100
  24. Vesterbacka M, 2012, ORTHOD CRANIOFAC RES, V15, P21, DOI 10.1111/j.1601-6343.2011.01533.x

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPE
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - LIM/36
Artigos e Materiais de Revistas Científicas - ODS/03