Walking Training Improves Ambulatory Blood Pressure Variability in Claudication

dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCHEHUEN, Marcel da Rocha
dc.contributor.authorCUCATO, Gabriel Grizzo
dc.contributor.authorCARVALHO, Celso Ricardo Fernandes de
dc.contributor.authorZERATI, Antonio Eduardo
dc.contributor.authorLEICHT, Anthony
dc.contributor.authorWOLOSKER, Nelson
dc.contributor.authorRITTI-DIAS, Raphael Mendes
dc.contributor.authorFORJAZ, Claudia Lucia de Moraes
dc.date.accessioned2021-06-17T13:51:56Z
dc.date.available2021-06-17T13:51:56Z
dc.date.issued2021
dc.description.abstractBackground: Walking training (WT) improves walking capacity and reduces clinic blood pressure (BP) in patients with peripheral artery disease (PAD), but its effects on ambulatory BP remains unknown. Objectives: To investigate the effect of 12 weeks of WT on ambulatory BP and its variability in patients with PAD. Methods: Thirty-five male patients with PAD and claudication symptoms were randomly allocated into two groups: control (n = 16, 30 min of stretching) and WT (n = 19, 15 bouts of 2 min of walking at the heart rate of leg pain threshold interspersed by 2 min of upright rest). Before and after 12 weeks, 24-hour ambulatory BP was assessed. Ambulatory BP variability indices assessed at both time points included the 24-hour standard deviation (SD 24), the awake and asleep weighted standard deviation (SD dn), and the 24-hour average real variability (ARV 24). Data were analyzed by mixed two-way ANOVAs, considering P<0.05 as significant. Results: After 12 weeks, neither group had significant changes in 24-hour, awake and sleep BPs. The WT decreased systolic and mean BP variabilities (Systolic BP - 13.3 +/- 2.8 vs 11.8 +/- 2.3, 12.1 +/- 2.84 vs 10.7 +/- 2.5 and 9.4 +/- 2.3 vs 8.8 +/- 2.2 mmHg); Mean BP - 11.0 +/- 1.7 vs 10.4 +/- 1.9, 10.1 +/- 1.6 vs 9.1 +/- 1.7 and 8.0.+/- 1.7 vs 7.2 +/- 1.5 mmHg) for SD 24, SD dn and ARV 24, respectively). Neither group had significant changes in diastolic BP variabilities after 12 weeks. Conclusion: The WT does not change ambulatory BP levels but decreases ambulatory BP variability in patients with PAD. This improvement may have a favorable impact on the cardiovascular risk of patients with symptomatic PAD.eng
dc.description.abstractFundamento: O treinamento de caminhada (TC) melhora a capacidade de caminhar e reduz a pressão arterial (PA) clínica em pacientes com doença arterial periférica (DAP), mas seus efeitos na PA ambulatorial permanecem desconhecidos. Objetivo: Investigar o efeito de 12 semanas de TC na PA ambulatorial e sua variabilidade em pacientes com DAP. Métodos:Trinta e cinco pacientes do sexo masculino com DAP e sintomas de claudicação foram alocados aleatoriamente em dois grupos: controle (n = 16, 30 min de alongamento) e TC (n = 19, 15 séries de 2 minutos de caminhada na frequência cardíaca em que ocorreu limiar de dor intercalados por 2 minutos de repouso em pé). Antes e depois de 12 semanas, a PA ambulatorial de 24 horas foi avaliada. Os índices de variabilidade da PA ambulatorial avaliados em ambos os momentos incluíram o desvio-padrão de 24 horas (DP24), o desvio-padrão ponderado de vigília e sono (DPvs) e a variabilidade real média de 24 horas (VRM24). Os dados foram analisados por ANOVAs mistas de dois fatores, considerando significativo P<0,05. Resultados: Após 12 semanas, nenhum dos grupos apresentou alterações na PA de 24 horas, vigília e sono. O TC diminuiu as variabilidades da PA sistólica e média (PA sistólica – 13,3 ± 2,8 vs 11,8 ± 2,3; 12,1 ± 2,84 vs 10,7 ± 2,5; e 9,4 ± 2,3 vs 8,8 ± 2,2 mmHg; PA média – 11,0 ± 1,7 vs 10,4 ± 1,9; 10,1 ± 1,6 vs 9,1 ± 1,7; e 8,0 ± 1,7 vs 7,2 ± 1,5 mmHg para DP24, DPvs e VRM24, respectivamente). Nenhum dos grupos apresentou mudanças significantesnos índices de variabilidade da PA diastólica após 12 semanas. Conclusões: O TC não altera os níveis ambulatoriais da PA, mas diminui a sua variabilidade em pacientes com DAP. Essa melhora pode ter um impacto favorável no risco cardiovascular de pacientes com DAP sintomática.
dc.description.indexMEDLINEeng
dc.description.sponsorshipCNPQConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [442507/2014-3, 304436/2018-6]
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2015/13800-0]
dc.description.sponsorshipCAPESCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [0001]
dc.identifier.citationARQUIVOS BRASILEIROS DE CARDIOLOGIA, v.116, n.5, p.898-905, 2021
dc.identifier.doi10.36660/abc.20190822
dc.identifier.issn0066-782X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/40649
dc.language.isoeng
dc.language.isopor
dc.publisherARQUIVOS BRASILEIROS CARDIOLOGIAeng
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.rightsopenAccesseng
dc.rights.holderCopyright ARQUIVOS BRASILEIROS CARDIOLOGIAeng
dc.subjectIntermittent Claudicationeng
dc.subjectWalkingeng
dc.subjectBlood Pressureeng
dc.subjectBlood Pressure Monitoring Ambulatoryeng
dc.subjectMuscle Weaknesseng
dc.subjectEndurance Trainingeng
dc.subjectCaminhada
dc.subjectClaudicação Intermitente
dc.subjectFraqueza Muscular
dc.subjectMonitoração Ambulatorial da Pressão Arterial
dc.subjectPressão Arterial
dc.subjectTreinamento Aeróbico
dc.subject
dc.subject.otherperipheral arterial-diseaseeng
dc.subject.otherlower-extremityeng
dc.subject.otherassociationeng
dc.subject.othermanagementeng
dc.subject.otherofficeeng
dc.subject.wosCardiac & Cardiovascular Systemseng
dc.titleWalking Training Improves Ambulatory Blood Pressure Variability in Claudicationeng
dc.title.alternativeTreinamento de Caminhada Melhora a Variabilidade da Pressão Arterial Ambulatorial em Claudicantes
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisoau
hcfmusp.author.externalCHEHUEN, Marcel da Rocha:Univ Sao Paulo, Escola Educ Fis & Esporte, Av Prof Mello Moraes 65,Cidade Univ, BR-05508030 Sao Paulo, SP, Brazil
hcfmusp.author.externalCUCATO, Gabriel Grizzo:Northumbria Univ, Newcastle Upon Tyne, Tyne & Wear, England
hcfmusp.author.externalLEICHT, Anthony:James Cook Univ, Douglas, Qld, Australia
hcfmusp.author.externalWOLOSKER, Nelson:Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
hcfmusp.author.externalRITTI-DIAS, Raphael Mendes:Univ Nove Julho, Programa Posgrad Ciencias Reabil, Sao Paulo, SP, Brazil
hcfmusp.author.externalFORJAZ, Claudia Lucia de Moraes:Univ Sao Paulo, Escola Educ Fis & Esporte, Av Prof Mello Moraes 65,Cidade Univ, BR-05508030 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcCELSO RICARDO FERNANDES DE CARVALHO
hcfmusp.contributor.author-fmusphcANTONIO EDUARDO ZERATI
hcfmusp.description.beginpage898
hcfmusp.description.endpage905
hcfmusp.description.issue5
hcfmusp.description.volume116
hcfmusp.origemWOS
hcfmusp.origem.pubmed34008811
hcfmusp.origem.scieloSCIELO:S0066-782X2021000600898
hcfmusp.origem.scopus2-s2.0-85106195220
hcfmusp.origem.wosWOS:000653679200009
hcfmusp.publisher.cityRIO DE JANEIROeng
hcfmusp.publisher.countryBRAZILeng
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hcfmusp.scopus.lastupdate2024-05-11
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