Does Arterialization of Portal Vein Have Any Effects in Large-for-Size Liver Transplantation? Hemodynamic, Histological, and Biomolecular Experimental Studies

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTORRES, Rafael Rodrigues
dc.contributor.authorTANNURI, Ana Cristina Aoun
dc.contributor.authorSERAFINI, Suellen
dc.contributor.authorBELON, Alessandro
dc.contributor.authorGONCALVES, Josiane Oliveira
dc.contributor.authorLORETO, Celso di
dc.contributor.authorTANNURI, Uenis
dc.date.accessioned2022-06-20T15:31:06Z
dc.date.available2022-06-20T15:31:06Z
dc.date.issued2022
dc.description.abstractBackground: In pediatric liver transplantation, the optimal size of the transplanted liver ranges between 0.8% and 4.0% of the recipient's weight. Sometimes, the graft weight exceeds this upper limit, characterizing the large-for-size condition potentially associated with reduced blood flow and worsening of ischemia-reperfusion injury. Therefore, it would be beneficial to increase the portal flow through arterialization of the portal vein. Materials and methods: Fifteen pigs underwent large-for-size liver transplants. They were divided into two groups: control (CTRL 6 animals - conventional technique) and arterialization - a shunt was established between the portal vein and the splenic artery (ART 9 animals). Hemodynamic, biochemical, histological, and molecular variables were compared. Results: Arterialization resulted in a significant increase in portal vein pressure but no changes in other hemodynamic variables, as shown in the analysis of variance. It was observed lower ALT values (p = 0.007), with no differences regarding the values of blood pH and lactate (p = 0.54 and p = 0.699 respectively) or histological variables (edema, steatosis, inflammation, necrosis, and IRI - p = 1.0, p = 0.943, p = 0.174, p = 0.832, p = 0.662, respectively). The molecular studies showed significantly increased expression of IL6 after 3 hours of reperfusion (p = 0.048) and decreased expression of ICAM immediately after reperfusion (p = 0.03). The regression analysis suggested a positive influence of portal flow and pressure on biochemical parameters. Conclusion: Arterialization of the portal vein showed no histological, biochemical, or molecular benefits in large-for-size transplantation.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2016/19098-9]
dc.identifier.citationJOURNAL OF INVESTIGATIVE SURGERY, v.35, n.6, p.1197-1207, 2022
dc.identifier.doi10.1080/08941939.2021.2021333
dc.identifier.eissn1521-0553
dc.identifier.issn0894-1939
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/47205
dc.language.isoeng
dc.publisherTAYLOR & FRANCIS INCeng
dc.relation.ispartofJournal of Investigative Surgery
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright TAYLOR & FRANCIS INCeng
dc.subjectLarge-for-size liver transplantationeng
dc.subjectcomplications of liver transplantationeng
dc.subjectliver transplantationeng
dc.subjectpediatric liver transplantationeng
dc.subjectanimal modeleng
dc.subject.otherischemia-reperfusion injuryeng
dc.subject.othersalvage procedureeng
dc.subject.othermodeleng
dc.subject.otherhepatectomyeng
dc.subject.othermechanismseng
dc.subject.wosSurgeryeng
dc.titleDoes Arterialization of Portal Vein Have Any Effects in Large-for-Size Liver Transplantation? Hemodynamic, Histological, and Biomolecular Experimental Studieseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcRAFAEL RODRIGUES TORRES
hcfmusp.contributor.author-fmusphcANA CRISTINA AOUN TANNURI
hcfmusp.contributor.author-fmusphcSUELLEN SERAFINI
hcfmusp.contributor.author-fmusphcALESSANDRO RODRIGO BELON
hcfmusp.contributor.author-fmusphcJOSIANE DE OLIVEIRA GONCALVES
hcfmusp.contributor.author-fmusphcCELSO DI LORETO
hcfmusp.contributor.author-fmusphcUENIS TANNURI
hcfmusp.description.beginpage1197
hcfmusp.description.endpage1207
hcfmusp.description.issue6
hcfmusp.description.volume35
hcfmusp.origemWOS
hcfmusp.origem.pubmed34965813
hcfmusp.origem.scopus2-s2.0-85122076034
hcfmusp.origem.wosWOS:000736438100001
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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