Periprostatic innervation: New issues based on segmental analysis of 10 human cadaver pelvic blocs

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRODRIGUES, Tiago M.
dc.contributor.authorMITRE, Anuar I.
dc.contributor.authorSILVA, Luiz Fernando F. da
dc.contributor.authorCASTILHO, Lisias N.
dc.contributor.authorSIMOES, Fabiano A.
dc.contributor.authorSALDIVA, Paulo H. N.
dc.contributor.authorSROUGI, Miguel
dc.date.accessioned2017-08-17T19:12:20Z
dc.date.available2017-08-17T19:12:20Z
dc.date.issued2017
dc.description.abstractBackgroundThe exact paths of periprostatic nerves have been under debate over the last decades. In the present study, the topographic distribution of nerves around the prostate and their relative distances from the prostatic capsule were analyzed in male cadaver visceral blocs. MethodsThe pelvic organs from ten fresh male cadavers were removed and serial sectioned en bloc for histological investigation. The macroslices was divided into four sectors. Each sector was centrally covered with a raster dividing each sector in three subsectors numbered clockwise. The prostatic capsule was identified, and distances of 2.5 and 5mm from the prostate were demarked with lines. We quantified the number of nerve fibers present in each subsector of each slide and recorded their position relative to the prostatic capsule. ResultsIn general, the topographic analysis revealed that the majority of nerves were identified in sectors 4 through 9, corresponding to the posterolateral and posterior surfaces of the prostate gland. At the prostate base, the majority of nerves were found at the posterolateral and posterior surfaces of the gland. Within the mid-region of the prostate, the same topographic distribution pattern was observed, but the nerve fibers were closer to the prostatic capsule. At the apical region, the percentage of nerve fibers identified in the anterior region was higher, despite their major concetration in the posterior surface. The nerves identified at the apex were mainly located up to 2.5mm from the prostate. This proximity to the prostate was specifically observed in the anterolateral and anterior sectors. In the craniocaudal sense, the percentage of nerves identified between 2.5 and 5mm from the prostatic capsule remained constant. ConclusionsA significant number of nerve fibers were present in the anterior and anterolateral positions, especially at the apex. The anterior nerves were closer to the prostate. This proximity suggests that the anterior nerves may participate in local physiology and that the cavernous nerves are probably formed by the posterior nerve fibers. It is likely that the safe distance of 2.5mm from all surfaces of the prostate may be related to cavernous fiber preservation.
dc.description.indexMEDLINE
dc.identifier.citationPROSTATE, v.77, n.10, p.1151-1159, 2017
dc.identifier.doi10.1002/pros.23374
dc.identifier.eissn1097-0045
dc.identifier.issn0270-4137
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/21196
dc.language.isoeng
dc.publisherWILEY
dc.relation.ispartofProstate
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY
dc.subjectnerve fibers
dc.subjectprostate
dc.subjectprostatectomy
dc.subjectsexual dysfunction
dc.subject.otherradical retropubic prostatectomy
dc.subject.othervattikuti-institute prostatectomy
dc.subject.otherneurovascular bundle
dc.subject.othercurtain dissection
dc.subject.othersexual function
dc.subject.otherpreservation
dc.subject.othernerves
dc.subject.otherfascia
dc.subject.othertissue
dc.subject.otherveil
dc.subject.wosEndocrinology & Metabolism
dc.subject.wosUrology & Nephrology
dc.titlePeriprostatic innervation: New issues based on segmental analysis of 10 human cadaver pelvic blocs
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcTIAGO MOURA RODRIGUES
hcfmusp.contributor.author-fmusphcANUAR IBRAHIM MITRE
hcfmusp.contributor.author-fmusphcLUIZ FERNANDO FERRAZ DA SILVA
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcMIGUEL SROUGI
hcfmusp.description.beginpage1151
hcfmusp.description.endpage1159
hcfmusp.description.issue10
hcfmusp.description.volume77
hcfmusp.origemWOS
hcfmusp.origem.pubmed28573651
hcfmusp.origem.scopus2-s2.0-85020061724
hcfmusp.origem.wosWOS:000404367500011
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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