Referências

1. Diamanti-Kandarakis, E., Bourguignon, J.-P., Giudice, L.C., Hauser, R., Prins, G.S., Soto, A.M., Zoeller, R.T., Gore, A.C., Endocrine-disrupting chemicals: An Endocrine Society scientific statement (2009) Endocr Rev, 30 (4), pp. 293-342
2. Gore, A., Chappell, V., Fenton, S., Flaws, J., Nadal, A., Prins, G., Toppari, J., Zoeller, R., EDC-2: The Endocrine Society’s second scientific statement on endocrine-disrupting chemicals (2015) Endocr Rev, 36, pp. e1-150
3. Bigsby, R., Chapin, R.E., Daston, G.P., Davis, B.J., Gorski, J., Gray, L.E., Howdeshell, K.L., Vom Saal, F.S., Evaluating the effects of endocrine disruptors on endocrine function during development (1999) Environ Health Perspect, 107 (4), p. 613
4. Maffini, M.V., Rubin, B.S., Sonnenschein, C., Soto, A.M., Endocrine disruptors and reproductive health: The case of bisphenol-A (2006) Mol Cell Endocrinol, 254, pp. 179-186
5. Biles, J., Mc Neal, T., Begley, T., Hollifield, H., Determination of bisphenol-A in reusable polycar-bonate food-contact plastics and migration to food-simulating liquids (1997) J Agric Food Chem, 45 (9), pp. 3541-3544
6. Michalowicz, J., Bisphenol A-sources, toxicity and biotransformation (2014) Environ Toxicol Pharmacol, 37 (2), pp. 738-758
7. Takeuchi, T., Tsutsumi, O., Serum Bisphenol, A., Concentrations showed gender differences, pos-sibly linked to androgen levels (2002) Biochem Biophys Res Commun, 291 (1), pp. 76-78
8. Ikezuki, Y., Tsutsumi, O., Takai, Y., Kamei, Y., Taketani, Y., Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure (2002) Hum Reprod, 17 (11), pp. 2839-2841
9. Schonfelder, G., Flick, B., Mayr, E., Talsness, C., Paul, M., Chahoud, I., In utero exposure to low doses of bisphenol A lead to long-term deleterious effects in the vagina (2002) Neoplasia, 4 (2), pp. 98-102
10. Sun, Y., Irie, M., Kishikawa, N., Wada, M., Kuroda, N., Nakashima, K., Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection (2004) Biomed Chromatogr, 18 (8), pp. 501-507
11. Calafat, A.M., Kuklenyik, Z., Reidy, J.A., Caudill, S.P., Ekong, J., Needham, L.L., Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population (2005) Environ Health Perspect, 113, pp. 391-395
12. Arakawa, C., Fujimaki, K., Yoshinaga, J., Imai, H., Serizawa, S., Shiraishi, H., Daily urinary excretion of bisphenol A (2004) Environ Health Prev Med, 9 (1), pp. 22-26
13. Wetherill, Y.B., Fisher, N.L., Staubach, A., Danielsen, M., De Vere White, R.W., Knudsen, K.E., Xenoestrogen action in prostate cancer: Pleiotropic effects dependent on androgen recep-tor status (2005) Cancer Res, 65 (1), pp. 54-65
14. Iso, T., Watanabe, T., Iwamoto, T., Shimamoto, A., Furuichi, Y., DNA damage caused by bisphenol A and estradiol through estrogenic activity (2006) Biol Pharm Bull, 29 (2), pp. 206-210
15. Ziv-Gal, A., Craig, Z.R., Wang, W., Flaws, J.A., Bisphenol, A., Inhibits cultured mouse ovarian follicle growth partially via the aryl hydrocarbon receptor signaling pathway (2013) Reprod Toxicol, 42, pp. 58-67
16. Wetherill, Y.B., Akingbemi, B.T., Kanno, J., Mc Lachlan, J.A., Nadal, A., Sonnenschein, C., Watson, C.S., Belcher, S.M., In vitro molecular mechanisms of bisphenol A action (2007) Reprod Toxicol, 24 (2), pp. 178-198
17. Gupta, C., Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals (2000) Proc Soc Exp Biol Med, 224 (2), pp. 61-68
18. Timms, B.G., Howdeshell, K.L., Barton, L., Bradley, S., Richter, C.A., Vom Saal, F.S., Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra (2005) Proc Natl Acad Sci U S A, 102 (19), pp. 7014-7019
19. Vom Saal, F.S., Cooke, P.S., Buchanan, D.L., Palanza, P., Thayer, K.A., Nagel, S.C., Parmigiani, S., Welshons, W.V., A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior (1998) Toxicol Ind Health, 14 (1-2), pp. 239-260
20. Ramos, J.G., Varayoud, J., Sonnenschein, C., Soto, A.M., De Toro, M.M., Luque, E.H., Prenatal exposure to low doses of bisphenol A alters the periductal stroma and glandular cell function in the rat ventral prostate (2001) Biol Reprod, 65 (4), pp. 1271-1277
21. Savchuk, I., Soder, O., Svechnikov, K., Mouse leydig cells with different androgen production potential are resistant to estrogenic stimuli but responsive to bisphenol a which attenuates testosterone metabolism (2013) Plos One, 15 (8), pp. e71722
22. Nanjappa, M.K., Ahuja, M., Dhanasekaran, M., Coleman, E.S., Braden, T.D., Bartol, F.F., Bird, R.C., Bisphenol, A., Regulation of testicular endocrine function in male rats is affected by diet (2014) Toxicol Lett, 225 (3), pp. 479-487
23. Chouhan, S., Yadav, S.K., Prakash, J., Westfall, S., Ghosh, A., Agarwal, N.K., Singh, S.P., Increase in the expression of inducible nitric oxide synthase on exposure to bisphenol A: A possible cause for decline in steroidogenesis in male mice (2015) Environ Toxicol Pharmacol, 39 (1), pp. 405-416
24. Maamar, M.B., Lesné, L., Desdoits-Lethimonier, C., Coiffec, I., Lassurguère, J., Lavoué, V., Deceuninck, Y., Perdu, E., An investigation of the endocrine-disruptive effects of bisphenol A in human and rat fetal testes (2015) Plos One., 10 (2), pp. e0117226
25. De Vries, G.J., Simerly, R.B., Anatomy, development, and function of sexually dimorphic neural circuits in the mammalian brain (2002) Horm Brain Behav, 4, pp. 137-191
26. Rubin, B.S., Lenkowski, J.R., Schaeberle, C.M., Vandenberg, L.N., Ronsheim, P.M., Soto, A.M., Evidence of altered brain sexual differentiation in mice exposed perinatally to low, environmentally relevant levels of bisphenol A (2006) Endocrinology, 147 (8), pp. 3681-3691
27. Funabashi, T., Kawaguchi, M., Furuta, M., Fukushima, A., Kimura, F., Exposure to bisphenol A dur-ing gestation and lactation causes loss of sex difference in corticotropin-releasing hormone-immunoreactive neurons in the bed nucleus of the stria terminalis of rats (2004) Psychoneuroendocrinology, 29 (4), pp. 475-485
28. Kubo, K., Arai, O., Omura, M., Watanabe, R., Ogata, R., Aou, S., Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats (2003) Neurosci Res, 45 (3), pp. 345-356
29. Meeker, J.D., Calafat, A.M., Hauser, R., Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic (2009) Environ Sci Technol, 44 (4), pp. 1458-1463
30. Doherty, L.F., Bromer, J.G., Zhou, Y., Aldad, T.S., Taylor, H.S., In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: An epigenetic mechanism linking endocrine disruptors to breast cancer (2010) Horm Cancer, 1 (3), pp. 146-155
31. Clayton, R., Erin, M., Todd, M., Dowd, J.B., Aiello, A.E., The impact of bisphenol A and triclosan on immune parameters in the U. S. Population, NHANES 2003-2006 (2010) Environ Health Perspect, 119 (3), pp. 390-396
32. Hassan, Z.K., Elobeid, M.A., Virk, P., Omer, S.A., Elamin, M., Daghestani, M.H., Alolayan, E.M., Bisphenol A induces hepatotoxicity through oxidative stress in rat model (2012) Oxid Med Cell Longev, 2012
33. Teppala, S., Madhavan, S., Shankar, A., Bisphenol A and metabolic syndrome: Results from NHANES (2012) Int J Endocrinol, 2012
34. Shankar, A., Teppala, S., Sabanayagam, C., Bisphenol A and peripheral arterial disease: Results from the NHANES (2012) Environ Health Perspect, 120 (9), p. 1297
35. Xing, L., Xu, Y., Xiao, Y., Shang, L., Liu, R., Wei, X., Jiang, J., Hao, W., Embryotoxic and teratogenic effects of the combination of bisphenol A and genistein on in vitro cultured postimplantation rat embryos (2010) Toxicol Sci, 115, p. 577
36. Mably, T.A., Moore, R.W., Peterson, R.E., In utero and lactational exposure of male rats to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin: I. Effects on androgenic status (1992) Toxicol Appl Pharmacol, 114 (1), pp. 97-107
37. Petersen, M., Halling, J., Weihe, P., Jensen, T., Grandjean, P., Nielsen, F., Jorgensen, N., Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls (2015) Environ Res, 138, pp. 345-351
38. Ruder, A.M., Hein, M.J., Hopf, N.B., Waters, M.A., Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: A ten-year update (2014) Int J Hyg Environ Health, 217 (2), pp. 176-187
39. Khan, I.A., Thomas, P., Disruption of neuroendocrine control of luteinizing hormone secretion by Aroclor 1254 involves inhibition of hypothalamic tryptophan hydroxylase activity (2001) Biol Reprod, 64 (3), pp. 955-964
40. Dickerson, S.M., Cunningham, S.L., Gore, A.C., Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus (2011) Toxicol Appl Pharmacol, 252 (1), pp. 36-46
41. Vested, A., Giwercman, A., Bonde, J.P., Toft, G., Persistent organic pollutants and male reproductive health (2014) Asian J Androl, 16 (1), p. 71
42. Sharpe, R.M., Environmental/lifestyle effects on spermatogenesis (2010) Phil Trans Roy Soc B Biol Sci, 365 (1546), pp. 1697-1712
43. Doyle, T.J., Bowman, J.L., Windell, V.L., Mc Lean, D.J., Kim, K.H., Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice (2013) Biol Reprod, 88 (5), p. 112
44. Chen, J., Wu, S., Wen, S., Shen, L., Peng, J., Yan, C., Cao, X., Lin, T., The mechanism of environmental endocrine disruptors (DEHP) induces epigenetic transgenerational inheri-tance of cryptorchidism (2015) Plos One, 10 (6), pp. e0126403
45. Foster, P., Disruption of reproductive development in male rat offspring following in utero exposure to phthalate esters (2006) Int J Androl, 29 (1), pp. 140-147
46. Joensen, U.N., Veyrand, B., Antignac, J.-P., Jensen, M.B., Petersen, J.H., Marchand, P., Skakkebæk, N.E., Jorgensen, N., PFOS (Perfluorooctanesulfonate) in serum is nega-tively associated with testosterone levels, but not with semen quality, in healthy men (2013) Hum Reprod, 28 (3), pp. 599-608
47. Lopez-Doval, S., Salgado, R., Pereiro, N., Moyano, R., Lafuente, A., Perfluorooctane sulfonate effects on the reproductive axis in adult male rats (2014) Environ Res, 134, pp. 158-168
48. Sierra-Santoyo, A., Hernandez, M., Albores, A., Cebrian, M.E., DDT increases hepatic testosterone metabolism in rats (2005) Arch Toxicol, 79 (1), pp. 7-12
49. Ye, L., Su, Z.-J., Ge, R.-S., Inhibitors of testosterone biosynthetic and metabolic activation enzymes (2011) Molecules, 16 (12), pp. 9983-10001
50. Bhosle, N.B., Garg, A., Jadhav, S., Harjee, R., Sawant, S.S., Venkat, K., Anil, A., Butyltins in water, biofilm, animals and sediments of the west coast of India (2004) Chemosphere, 57 (8), pp. 897-907
51. Lo, S., Alléra, A., Albers, P., Heimbrecht, J., Jantzen, E., Klingmüller, D., Steckelbroeck, S., Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism (2003) J Steroid Biochem Mol Biol, 84 (5), pp. 569-576
52. Ohno, S., Nakajima, Y., Nakajin, S., Triphenyltin and Tributyltin inhibit pig testicular 17p-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis (2005) Steroids, 70 (9), pp. 645-651
53. Doering, D.D., Steckelbroeck, S., Doering, T., Klingmüller, D., Effects of butyltins on human 5a-reductase type 1 and type 2 activity (2002) Steroids, 67 (10), pp. 859-867
54. Janer, G., Sternberg, R., Leblanc, G., Porte, C., Testosterone conjugating activities in invertebrates: Are they targets for endocrine disruptors? (2005) Aquat Toxicol, 71 (3), pp. 273-282
55. Clement, T.M., Savenkova, M.I., Settles, M., Anway, M.D., Skinner, M.K., Alterations in the develop-ing testis transcriptome following embryonic vinclozolin exposure (2010) Reprod Toxicol, 30 (3), pp. 353-364
56. Anway, M.D., Cupp, A.S., Uzumcu, M., Skinner, M.K., Epigenetic transgenerational actions of endocrine disruptors and male fertility (2005) Science, 308 (5727), pp. 1466-1469
57. Swan, S.H., Main, K.M., Liu, F., Stewart, S.L., Kruse, R.L., Calafat, A.M., Mao, C.S., Sullivan, S., Decrease in anogenital distance among male infants with prenatal phthalate exposure (2005) Environ Health Perspect, 113, pp. 1056-1061
58. Bay, K., Asklund, C., Skakkebaek, N.E., Ersson, A.-M., Testicular dysgenesis syndrome: Possible role of endocrine disrupters (2006) Best Prac Res Clin Endocrinol Metab, 20 (1), pp. 77-90
59. Gaspari, L., Paris, F., Philibert, P., Audran, F., Orsini, M., Servant, N., Maïmoun, L., Kalfa, N., Sultan C: ‘Idiopathic’ partial androgen insensitivity syndrome in 28 newborn and infant males: Impact of prenatal exposure to environmental endocrine disruptor chemicals? (2011) Eur J Endocrinol, 165 (4), pp. 579-587
60. Hauser, R., Skakkebaek, N.E., Hass, U., Toppari, J., Juul, A., Ersson, A.M., Kortenkamp, A., Trasande, L., Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union (2015) J Clin Endocrinol Metab, 100 (4), pp. 1267-1277
61. Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Yamada, T., Brain masculinization requires androgen receptor function (2004) Proc Natl Acad Sci U S A, 101 (6), pp. 1673-1678
62. Bakker, J., Honda, S., Harada, N., Balthazart, J., The aromatase knockout (ArKO) mouse provides new evidence that estrogens are required for the development of the female brain (2003) Ann N Y Acad Sci, 1007 (1), pp. 251-262
63. Lichtensteiger, W., Bassetti-Gaille, C., Faass, O., Axelstad, M., Boberg, J., Christiansen, S., Rehrauer, H., Kortenkamp, A., Differential gene expression patterns in developing sexually dimorphic rat brain regions exposed to antiandrogenic, estrogenic, or complex endocrine disruptor mixtures: Glutamatergic synapses as target (2015) Endocrinology, 156 (4), pp. 1477-1493
64. Grumbach, M.M., Styne, D.M., Puberty: Ontogeny, neuroendocrinology, physiology, and disor-ders (1998) Williams Textb Endocrinol, 9, pp. 1509-1625
65. Zawatski, W., Lee, M.M., Male pubertal development: Are endocrine-disrupting compounds shift-ing the norms? (2013) J Endocrinol, 218 (2), pp. R1-12
66. Howdeshell, K.L., Hotchkiss, A.K., Thayer, K.A., Vandenbergh, J.G., Vom Saal, F.S., Environmental toxins: Exposure to bisphenol A advances puberty (1999) Nature, 401 (6755), pp. 763-764
67. Ge, R.S., Chen, G.R., Dong, Q., Akingbemi, B., Sottas, C.M., Santos, M., Sealfon, S.C., Hardy, M.P., Biphasic effects of postnatal exposure to diethylhexyl phthalate on the timing of puberty in male rats (2007) J Androl, 28 (4), pp. 513-520
68. Den Hond, E., Schoeters, G., Endocrine disrupters and human puberty (2006) Int J Androl, 29 (1), pp. 264-271
69. Del Rio Gomez, I., Marshall, T., Tsai, P., Shao, Y.-S., Guo, Y.L., Number of boys born to men exposed to polychlorinated byphenyls (2002) Lancet, 360 (9327), pp. 143-144
70. Mieritz, M.G., Frederiksen, H., Sorensen, K., Aksglaede, L., Mouritsen, A., Hagen, C.P., Skakkebaek, N.E., Juul, A., Urinary phthalate excretion in 555 healthy Danish boys with and without pubertal gynaecomastia (2012) Int J Androl, 35 (3), pp. 227-235
71. Bujan, L., Mansat, A., Pontonnier, F., Mieusset, R., Time series analysis of sperm concentration in fertile men in Toulouse, France between 1977 and 1992 (1996) BMJ, 312 (7029), pp. 471-472
72. Carlsen, E., Giwercman, A., Keiding, N., Skakkebaek, N.E., Evidence for decreasing quality of semen during past 50 years (1992) BMJ, 305 (6854), pp. 609-613
73. Duty, S.M., Silva, M.J., Barr, D.B., Brock, J.W., Ryan, L., Chen, Z., Herrick, R.F., Hauser, R., Phthalate exposure and human semen parameters (2003) Epidemiology, 14 (3), pp. 269-277
74. Jonsson, B.A., Richthoff, J., Rylander, L., Giwercman, A., Hagmar, L., Urinary phthalate metabolites and biomarkers of reproductive function in young men (2005) Epidemiology, 16 (4), pp. 487-493
75. Dallinga, J.W., Moonen, E.J., Dumoulin, J.C., Evers, J.L., Geraedts, J.P., Kleinjans, J.C., Decreased human semen quality and organochlorine compounds in blood (2002) Hum Reprod, 17 (8), pp. 1973-1979
76. Hsu, P.C., Huang, W., Yao, W.J., Wu, M.H., Guo, Y.L., Lambert, G.H., Sperm changes in men exposed to polychlorinated biphenyls and dibenzofurans (2003) JAMA, 289 (22), pp. 2943-2944
77. Mocarelli, P., Gerthoux, P.M., Patterson, D.G., Jr., Milani, S., Limonta, G., Bertona, M., Signorini, S., Needham, L.L., Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality (2008) Environ Health Perspect, 116 (1), pp. 70-77
78. Skakkebaek, N.E., Rajpert-De Meyts, E., Jorgensen, N., Main, K.M., Leffers, H., Ersson, A.M., Juul, A., Toppari, J., Testicular cancer trends as ‘whistle blowers’ of testicular develop-mental problems in populations (2007) Int J Androl, 30 (4), pp. 198-204. , discussion 204-205
79. Hemminki, K., Li, X., Cancer risks in Nordic immigrants and their offspring in Sweden (2002) Eur J Cancer, 38 (18), pp. 2428-2434
80. Hardell, L., Van Bavel, B., Lindstrom, G., Carlberg, M., Dreifaldt, A.C., Wijkstrom, H., Starkhammar, H., Kolmert, T., Increased concentrations of polychlorinated biphe-nyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer (2003) Environ Health Perspect, 111 (7), pp. 930-934
81. Zoeller, R.T., Brown, T., Doan, L., Gore, A., Skakkebaek, N., Soto, A., Woodruff, T., Vom Saal, F., Endocrine-disrupting chemicals and public health protection: A statement of principles from The Endocrine Society (2012) Endocrinology, 153 (9), pp. 4097-4110
82. Gore, A., Chappell, V., Fenton, S., Flaws, J., Nadal, A., Prins, G., Toppari, J., Zoeller, R., Executive sum-mary to EDC-2: The Endocrine Society’s second scientific statement on endocrine-disrupting chemicals (2015) Endocr Rev, 36 (6), pp. 593-602