Is Gilbert Syndrome a new risk factor for breast cancer?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorASTOLFI, Rafael Haddad
dc.contributor.authorBUGANO, Diogo Diniz Gomes
dc.contributor.authorFRANCISCO, Alice Aparecida Rodrigues Ferreira
dc.contributor.authorSOUZA, Marcelo Moreira Tavares de
dc.contributor.authorONO-NITA, Suzane Kioko
dc.contributor.authorBARACAT, Edmund Chada
dc.date.accessioned2017-11-27T16:27:09Z
dc.date.available2017-11-27T16:27:09Z
dc.date.issued2011
dc.description.abstractPatients with Gilbert Syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert Syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.
dc.description.indexMEDLINE
dc.identifier.citationMEDICAL HYPOTHESES, v.77, n.2, p.162-164, 2011
dc.identifier.doi10.1016/j.mehy.2011.03.047
dc.identifier.issn0306-9877
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23005
dc.language.isoeng
dc.publisherCHURCHILL LIVINGSTONE
dc.relation.ispartofMedical Hypotheses
dc.rightsrestrictedAccess
dc.rights.holderCopyright CHURCHILL LIVINGSTONE
dc.subject.otherudp-glucuronosyltransferase
dc.subject.othergenetic polymorphisms
dc.subject.otherpostmenopausal women
dc.subject.otherendogenous estrogens
dc.subject.otherbilirubin metabolism
dc.subject.otherreceptor status
dc.subject.otherugt1a1
dc.subject.otherphenotypes
dc.subject.wosMedicine, Research & Experimental
dc.titleIs Gilbert Syndrome a new risk factor for breast cancer?
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBUGANO, Diogo Diniz Gomes:Univ Sao Paulo, Hosp Clin, Dept Internal Med, BR-05508 Sao Paulo, Brazil
hcfmusp.author.externalFRANCISCO, Alice Aparecida Rodrigues Ferreira:Inst Brasileiro Controle Canc, Brasilia, DF, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcRAFAEL HADDAD ASTOLFI
hcfmusp.contributor.author-fmusphcMARCELO MOREIRA TAVARES DE SOUZA
hcfmusp.contributor.author-fmusphcSUZANE KIOKO ONO
hcfmusp.contributor.author-fmusphcEDMUND CHADA BARACAT
hcfmusp.description.beginpage162
hcfmusp.description.endpage164
hcfmusp.description.issue2
hcfmusp.description.volume77
hcfmusp.origemWOS
hcfmusp.origem.pubmed21636218
hcfmusp.origem.scopus2-s2.0-79960640102
hcfmusp.origem.wosWOS:000294039100002
hcfmusp.publisher.cityEDINBURGH
hcfmusp.publisher.countrySCOTLAND
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