Carbapenem-resistant Serratia marcescens bloodstream infection in hematopoietic stem cell transplantation patients: Will it be the next challenge?

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Citações na Scopus
3
Tipo de produção
article
Data de publicação
2021
Título da Revista
ISSN da Revista
Título do Volume
Editora
JOHN WILEY AND SONS INC
Citação
TRANSPLANT INFECTIOUS DISEASE, v.23, n.4, article ID e13630, p, 2021
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Unidades Organizacionais
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Resumo
Surveillance programs have been reporting decreasing rates of carbapenem-sensitivity in Serratia marcescens, leading to a concern regarding the few remaining therapeutic options to treat these multidrug-resistant (MDR) organisms. Here, we describe a case series of 11 stem cell hematopoietic transplantation patients infected (N = 6) or colonized (N = 5) by carbapenem-resistant S marcescens (CrSm) from 2010 to 2013. The comorbidities found were acute renal insufficiency (3/11), neutropenia (7/11), and mucositis (8/11), and the mortality rate was 64%. KPC was the most prevalent carbapenemase detected (8/11) and tigecycline and gentamicin were the antimicrobials used as treatment. © 2021 Wiley Periodicals LLC
Palavras-chave
bone marrow transplant, carbapenem-resistant Serratia, hematopoietic stem cell transplantation, KPC, NDM, Serratia marcescens
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