Genomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIMA-COSTA, M. Fernanda
dc.contributor.authorMACINKO, James
dc.contributor.authorMAMBRINI, Juliana Vaz de Mello
dc.contributor.authorPEIXOTO, Sergio Viana
dc.contributor.authorPEREIRA, Alexandre Costa
dc.contributor.authorTARAZONA-SANTOS, Eduardo
dc.contributor.authorRIBEIRO, Antonio Luiz Pinho
dc.date.accessioned2016-10-17T16:44:29Z
dc.date.available2016-10-17T16:44:29Z
dc.date.issued2016
dc.description.abstractBackground The influence of genetic ancestry on Trypanosoma cruzi infection and Chagas disease outcomes is unknown. Methodology/Principal Findings We used 370,539 Single Nucleotide Polymorphisms (SNPs) to examine the association between individual proportions of African, European and Native American genomic ancestry with T. cruzi infection and related outcomes in 1,341 participants (aged >= 60 years) of the Bambui (Brazil) population-based cohort study of aging. Potential confounding variables included sociodemographic characteristics and an array of health measures. The prevalence of T. cruzi infection was 37.5% and 56.3% of those infected had a major ECG abnormality. Baseline T. cruzi infection was correlated with higher levels of African and Native American ancestry, which in turn were strongly associated with poor socioeconomic circumstances. Cardiomyopathy in infected persons was not significantly associated with African or Native American ancestry levels. Infected persons with a major ECG abnormality were at increased risk of 15-year mortality relative to their counterparts with no such abnormalities (adjusted hazard ratio = 1.80; 95% 1.41, 2.32). African and Native American ancestry levels had no significant effect modifying this association. Conclusions/Significance Our findings indicate that African and Native American ancestry have no influence on the presence of major ECG abnormalities and had no influence on the ability of an ECG abnormality to predict mortality in older people infected with T. cruzi. In contrast, our results revealed a strong and independent association between prevalent T. cruzi infection and higher levels of African and Native American ancestry. Whether this association is a consequence of genetic background or differential exposure to infection remains to be determined.
dc.description.indexPubMed
dc.description.sponsorshipDepartment of Science and Technology (DECIT, Ministry of Health)
dc.description.sponsorshipNational Fund for Scientific and Technological Development (FNDCT, Ministry of Science and Technology)
dc.description.sponsorshipFunding of Studies and Projects (FINEP, Ministry of Science and Technology, Brazil)
dc.description.sponsorshipBrazilian National Research Council (CNPq)
dc.identifier.citationPLOS NEGLECTED TROPICAL DISEASES, v.10, n.5, article ID e0004724, 14p, 2016
dc.identifier.doi10.1371/journal.pntd.0004724
dc.identifier.issn1935-2735
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16452
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos Neglected Tropical Diseases
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othertrypanosoma-cruzi infection
dc.subject.otherblood-pressure
dc.subject.otherunited-states
dc.subject.otherhealth
dc.subject.othercommunity
dc.subject.othercardiomyopathy
dc.subject.othertransmission
dc.subject.othermortality
dc.subject.otherdiagnosis
dc.subject.otheradmixture
dc.subject.wosInfectious Diseases
dc.subject.wosParasitology
dc.subject.wosTropical Medicine
dc.titleGenomic African and Native American Ancestry and Chagas Disease: The Bambui (Brazil) Epigen Cohort Study of Aging
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLIMA-COSTA, M. Fernanda:Fundacao Oswaldo Cruz, Inst Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil
hcfmusp.author.externalMACINKO, James:Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA USA; Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Community Hlth Sci, Los Angeles, CA USA
hcfmusp.author.externalMAMBRINI, Juliana Vaz de Mello:Fundacao Oswaldo Cruz, Inst Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil
hcfmusp.author.externalPEIXOTO, Sergio Viana:Fundacao Oswaldo Cruz, Inst Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais, Escola Enfermagem, Dept Enfermagem Aplicada, Belo Horizonte, MG, Brazil
hcfmusp.author.externalTARAZONA-SANTOS, Eduardo:Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Belo Horizonte, MG, Brazil
hcfmusp.author.externalRIBEIRO, Antonio Luiz Pinho:Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil; Fac Med, Belo Horizonte, MG, Brazil
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.articlenumbere0004724
hcfmusp.description.issue5
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed27182885
hcfmusp.origem.scopus2-s2.0-84971597376
hcfmusp.origem.wosWOS:000377769300062
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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