Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBOCHI, Ana Paula Garcia
dc.contributor.authorFERREIRA, Guilherme da Silva
dc.contributor.authorBIANCO, Vanessa Del
dc.contributor.authorPINTO, Paula Ramos
dc.contributor.authorRODRIGUES, Leticia Gomes
dc.contributor.authorTREVISANI, Mayara da Silva
dc.contributor.authorFURUKAWA, Luzia Naoko Shinohara
dc.contributor.authorBISPO, Kely Cristina Soares
dc.contributor.authorSILVA, Alexandre Alves da
dc.contributor.authorVELOSA, Ana Paula Pereira
dc.contributor.authorNAKANDAKARE, Edna Regina
dc.contributor.authorMACHADO, Ubiratan Fabres
dc.contributor.authorTEODORO, Walcy Paganelli Rosolia
dc.contributor.authorPASSARELLI, Marisa
dc.contributor.authorCATANOZI, Sergio
dc.date.accessioned2022-12-21T13:17:44Z
dc.date.available2022-12-21T13:17:44Z
dc.date.issued2022
dc.description.abstractThis study investigated the efficacy of aerobic exercise training (AET) in the prevention of dyslipidemia, insulin resistance (IR), and atherogenesis induced by severe low-sodium (LS) diet. LDL receptor knockout (LDLR KO) mice were fed a low-sodium (LS) (0.15% NaCl) or normal-sodium (NS; 1.27% NaCl) diet, submitted to AET in a treadmill, 5 times/week, 60 min/day, 15 m/min, for 90 days, or kept sedentary. Blood pressure (BP), plasma total cholesterol (TC) and triglyceride (TG) concentrations, lipoprotein profile, and insulin sensitivity were evaluated at the end of the AET protocol. Lipid infiltration, angiotensin II type 1 receptor (AT1), receptor for advanced glycation end products (RAGE), carboxymethyllysine (CML), and 4-hydroxynonenal (4-HNE) contents as well as gene expression were determined in the brachiocephalic trunk. BP and TC and gene expression were similar among groups. Compared to the NS diet, the LS diet increased vascular lipid infiltration, CML, RAGE, 4-HNE, plasma TG, LDL-cholesterol, and VLDL-TG. Conversely, the LS diet reduced vascular AT1 receptor, insulin sensitivity, HDL-cholesterol, and HDL-TG. AET prevented arterial lipid infiltration; increases in CML, RAGE, and 4-HNE contents; and reduced AT1 levels and improved LS-induced peripheral IR. The current study showed that AET counteracted the deleterious effects of chronic LS diet in an atherogenesis-prone model by ameliorating peripheral IR, lipid infiltration, CML, RAGE, 4-HNE, and AT1 receptor in the intima-media of the brachiocephalic trunk. These events occurred independently of the amelioration of plasma-lipid profile, which was negatively affected by the severe dietary-sodium restriction.eng
dc.description.indexPubMedeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/15603-0]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq, Brazil
dc.identifier.citationANTIOXIDANTS, v.11, n.10, article ID 2023, 16p, 2022
dc.identifier.doi10.3390/antiox11102023
dc.identifier.eissn2076-3921
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/50384
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofAntioxidants
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectlow-sodium dieteng
dc.subjectatherogenesiseng
dc.subjectdyslipidemiaeng
dc.subjectaerobic-exercise trainingeng
dc.subjectinsulin resistanceeng
dc.subject.otherrenin-angiotensin systemeng
dc.subject.otherplasma-lipid concentrationeng
dc.subject.otherinsulin-resistanceeng
dc.subject.otheradvanced glycationeng
dc.subject.otheratherosclerotic plaqueseng
dc.subject.otherchloride restrictioneng
dc.subject.otherskeletal-muscleeng
dc.subject.otherat(1) receptoreng
dc.subject.othermechanismseng
dc.subject.otherhypercholesterolemiaeng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosChemistry, Medicinaleng
dc.subject.wosFood Science & Technologyeng
dc.titleAerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Miceeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalPINTO, Paula Ramos:Univ Sao Paulo, Lab Lipides LIM 10, Hosp Clin HCFMUSP, Fac Med, BR-01246000 Sao Paulo, Brazil
hcfmusp.author.externalRODRIGUES, Leticia Gomes:Univ Sao Paulo, Lab Lipides LIM 10, Hosp Clin HCFMUSP, Fac Med, BR-01246000 Sao Paulo, Brazil
hcfmusp.author.externalTREVISANI, Mayara da Silva:Univ Sao Paulo, Lab Lipides LIM 10, Hosp Clin HCFMUSP, Fac Med, BR-01246000 Sao Paulo, Brazil
hcfmusp.author.externalSILVA, Alexandre Alves da:Univ Mississippi, Mississippi Ctr Obes Res, Cardiorenal & Metab Dis Res Ctr, Dept Physiol & Biophys,Med Ctr, Jackson, MS 39216 USA
hcfmusp.author.externalMACHADO, Ubiratan Fabres:Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcANA PAULA GARCIA BOCHI
hcfmusp.contributor.author-fmusphcGUILHERME DA SILVA FERREIRA
hcfmusp.contributor.author-fmusphcVANESSA DEL BIANCO DE BENTO
hcfmusp.contributor.author-fmusphcLUZIA NAOKO SHINOHARA FURUKAWA
hcfmusp.contributor.author-fmusphcKELY CRISTINA SOARES BISPO
hcfmusp.contributor.author-fmusphcANA PAULA PEREIRA VELOSA
hcfmusp.contributor.author-fmusphcEDNA REGINA NAKANDAKARE
hcfmusp.contributor.author-fmusphcWALCY PAGANELLI ROSOLIA TEODORO
hcfmusp.contributor.author-fmusphcMARISA PASSARELLI
hcfmusp.contributor.author-fmusphcSERGIO CATANOZI
hcfmusp.description.articlenumber2023
hcfmusp.description.issue10
hcfmusp.description.volume11
hcfmusp.origemWOS
hcfmusp.origem.pubmed36290746
hcfmusp.origem.scopus2-s2.0-85140463180
hcfmusp.origem.wosWOS:000872009500001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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