Cachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBATISTA JR., Miguel L.
dc.contributor.authorHENRIQUES, Felipe S.
dc.contributor.authorNEVES, Rodrigo X.
dc.contributor.authorOLIVAN, Mireia R.
dc.contributor.authorMATOS-NETO, Emidio M.
dc.contributor.authorALCANTARA, Paulo S. M.
dc.contributor.authorMAXIMIANO, Linda F.
dc.contributor.authorOTOCH, Jose P.
dc.contributor.authorALVES, Michele J.
dc.contributor.authorSEELAENDER, Marilia
dc.date.accessioned2016-07-18T11:35:22Z
dc.date.available2016-07-18T11:35:22Z
dc.date.issued2016
dc.description.abstractBackground and aimsCachexia is a syndrome characterized by marked involuntary loss of body weight. Recently, adipose tissue (AT) wasting has been shown to occur before the appearance of other classical cachexia markers. We investigated the composition and rearrangement of the extracellular matrix, adipocyte morphology and inflammation in the subcutaneous AT (scAT) pad of gastrointestinal cancer patients. MethodsSurgical biopsies for scAT were obtained from gastrointestinal cancer patients, who were signed up into the following groups: cancer cachexia (CC, n=11), weight-stable cancer (WSC, n=9) and weight-stable control (non-cancer) (control, n=7). The stable weight groups were considered as those with no important weight change during the last year and body mass index <25kg/m(2). Subcutaneous AT fibrosis was quantified and characterized by quantitative PCR, histological analysis and immunohistochemistry. ResultsThe degree of fibrosis and the distribution and collagen types (I and III) were different in WSC and CC patients. CC patients showed more pronounced fibrosis in comparison with WSC. Infiltrating macrophages surrounding adipocytes and CD3 Ly were found in the fibrotic areas of scAT. Subcutaneous AT fibrotic areas demonstrated increased monocyte chemotactic protein 1 (MCP-1) and Cluster of Differentiation (CD)68 gene expression in cancer patients. ConclusionsOur data indicate architectural modification consisting of fibrosis and inflammatory cell infiltration in scAT as induced by cachexia in gastrointestinal cancer patients. The latter was characterized by the presence of macrophages and lymphocytes, more evident in the fibrotic areas. In addition, increased MCP-1 and CD68 gene expression in scAT from cancer patients may indicate an important role of these markers in the early phases of cancer.
dc.description.indexPubMed
dc.description.sponsorshipFAPESP [2010/51078-1, 2008/54091-9, 2012/50079-0]
dc.identifier.citationJOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v.7, n.1, p.37-47, 2016
dc.identifier.doi10.1002/jcsm.12037
dc.identifier.eissn2190-6009
dc.identifier.issn2190-5991
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14093
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofJournal of Cachexia Sarcopenia and Muscle
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectAdipose tissue
dc.subjectExtracellular matrix
dc.subjectFibrosis
dc.subjectInflammation
dc.subjectCachexia
dc.subject.otherextracellular-matrix
dc.subject.othercell-death
dc.subject.otherinflammation
dc.subject.otherexpression
dc.subject.otherobesity
dc.subject.othermechanisms
dc.subject.otherlipolysis
dc.subject.othermice
dc.subject.otherdefinition
dc.subject.othermetabolism
dc.subject.wosMedicine, General & Internal
dc.titleCachexia-associated adipose tissue morphological rearrangement in gastrointestinal cancer patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalBATISTA JR., Miguel L.:Univ Mogi das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, Brazil; Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalHENRIQUES, Felipe S.:Univ Mogi das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, Brazil
hcfmusp.author.externalNEVES, Rodrigo X.:Univ Mogi das Cruzes, Integrated Grp Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, Brazil; Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalOLIVAN, Mireia R.:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalMATOS-NETO, Emidio M.:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalALVES, Michele J.:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalSEELAENDER, Marilia:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.citation.scopus71
hcfmusp.contributor.author-fmusphcPAULO SERGIO MARTINS DE ALCANTARA
hcfmusp.contributor.author-fmusphcLINDA FERREIRA MAXIMIANO
hcfmusp.contributor.author-fmusphcJOSE PINHATA OTOCH
hcfmusp.description.beginpage37
hcfmusp.description.endpage47
hcfmusp.description.issue1
hcfmusp.description.volume7
hcfmusp.origemWOS
hcfmusp.origem.pubmed27066317
hcfmusp.origem.scopus2-s2.0-84961616346
hcfmusp.origem.wosWOS:000373200500005
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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