Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorJESUS, Jaqueline Goes de
dc.contributor.authorDUTRA, Karina Rocha
dc.contributor.authorSALES, Flavia Cristina da Silva
dc.contributor.authorCLARO, Ingra Morales
dc.contributor.authorTERZIAN, Ana Carolina
dc.contributor.authorCANDIDO, Darlan da Silva
dc.contributor.authorHILL, Sarah C.
dc.contributor.authorTHEZE, Julien
dc.contributor.authorTORRES, Celeste
dc.contributor.authorD'AGOSTINI, Tatiana Lang
dc.contributor.authorFELIX, Alvina Clara
dc.contributor.authorREIS, Andreia F. Negri
dc.contributor.authorALCANTAR, Luiz Carlos Junior
dc.contributor.authorABREU, Andre L. de
dc.contributor.authorCRODA, Julio H. R.
dc.contributor.authorOLIVEIRA, Wanderson K. de
dc.contributor.authorFILIPIS, Ana Maria Bispo de
dc.contributor.authorCAMIS, Maria do Carmo Rodrigues dos Santos
dc.contributor.authorROMANO, Camila Malta
dc.contributor.authorLOMAN, Nick J.
dc.contributor.authorPYBUS, Oliver G.
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorNOGUEIRA, Mauricio L.
dc.contributor.authorFARIA, Nuno Rodrigues
dc.date.accessioned2020-08-20T13:21:58Z
dc.date.available2020-08-20T13:21:58Z
dc.date.issued2020
dc.description.abstractBACKGROUND Despite efforts to mitigate the impact of dengue virus (DENV) epidemics, the virus remains a public health problem in tropical and subtropical regions around the world. Most DENV cases in the Americas between January and July 2019 were reported in Brazil. Sao Paulo State in the southeast of Brazil has reported nearly half of all DENV infections in the country. OBJECTIVES To understand the origin and dynamics of the 2019 DENV outbreak. METHODS Here using portable nanopore sequencing we generated20 new DENV genome sequences from viremic patients with suspected dengue infection residing in two of the most-affected municipalities of Sao Paulo State, Araraquara and Sao Jose do Rio Preto. We conducted a comprehensive phylogenetic analysis with 1,630 global DENV strains to better understand the evolutionary history of the DENV lineages that currently circulate in the region. FINDINGS The new outbreak strains were classified as DENV2 genotype III (American/Asian genotype). Our analysis shows that the 2019 outbreak is the result of a novel DENV lineage that was recently introduced to Brazil from the Caribbean region. Dating phylogeographic analysis suggests that DENV2-III BR-4 was introduced to Brazil in or around early 2014, possibly from the Caribbean region. MAIN CONCLUSIONS Our study describes the early detection of a newly introduced and rapidly-expanding DENV2 virus lineage in Brazil.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESP-MRC grant (CADDE) [FAPESP 2018/14389-0]
dc.description.sponsorshipWellcome TrustWellcome Trust
dc.description.sponsorshipRoyal Society Sir Henry Dale Fellowship [204311/Z/16/Z]
dc.description.sponsorshipCNPqNational Council for Scientific and Technological Development (CNPq) [400354/2016-0, 440685/2016-8, 440856/2016-7]
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/01735-2, 13/21719-3, 15/12295-0, 15/14313-6]
dc.description.sponsorshipOxford Martin School
dc.description.sponsorshipDecit/SCTIE/MoH
dc.description.sponsorshipCAPESCAPES [88887.130716/201600, 88881.130825/2016-00, 88887.130823/2016-00]
dc.description.sponsorshipEU's Horizon 2020 Programme through ZIKAlliance [PRES-005-FEX-17-4-2-33]
dc.identifier.citationMEMORIAS DO INSTITUTO OSWALDO CRUZ, v.115, article ID e190423, 6p, 2020
dc.identifier.doi10.1590/0074-02760190423
dc.identifier.eissn1678-8060
dc.identifier.issn0074-0276
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36872
dc.language.isoeng
dc.publisherFUNDACO OSWALDO CRUZeng
dc.relation.ispartofMemorias do Instituto Oswaldo Cruz
dc.rightsopenAccesseng
dc.rights.holderCopyright FUNDACO OSWALDO CRUZeng
dc.subjectdengue 2eng
dc.subjectoutbreakeng
dc.subjectgenomic surveillanceeng
dc.subjectlineage replacementeng
dc.subjectBrazileng
dc.subject.otherzika viruseng
dc.subject.othercirculationeng
dc.subject.wosParasitologyeng
dc.subject.wosTropical Medicineeng
dc.titleGenomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019eng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalDUTRA, Karina Rocha:Fac Med Sao Jose do Rio Preto, Lab Pesquisa Virol, Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalTERZIAN, Ana Carolina:Fac Med Sao Jose do Rio Preto, Lab Pesquisa Virol, Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalCANDIDO, Darlan da Silva:Univ Oxford, Dept Zool, Oxford, England
hcfmusp.author.externalHILL, Sarah C.:Univ Oxford, Dept Zool, Oxford, England
hcfmusp.author.externalTHEZE, Julien:Univ Oxford, Dept Zool, Oxford, England
hcfmusp.author.externalTORRES, Celeste:Inst Oswaldo Cruz, Fundacao Oswaldo Cruz Fiocruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalD'AGOSTINI, Tatiana Lang:Coordenadoria Controle Doencas Sao Paulo, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Secretaria Estado Saude, Sao Paulo, SP, Brazil
hcfmusp.author.externalREIS, Andreia F. Negri:Secretaria Municipal Saude, Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalALCANTAR, Luiz Carlos Junior:Inst Oswaldo Cruz, Fundacao Oswaldo Cruz Fiocruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil; Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil
hcfmusp.author.externalABREU, Andre L. de:Coordenacao Geral Lab Saude Publ, Secretaria Vigilancia Saude, Minist Saude, Brasilia, DF, Brazil
hcfmusp.author.externalCRODA, Julio H. R.:Coordenacao Geral Lab Saude Publ, Secretaria Vigilancia Saude, Minist Saude, Brasilia, DF, Brazil; Fundacao Univ Fed Grande Dourados, Lab Pesquisa Ciencias Saude, Dourados, MS, Brazil; Fiocruz MS, Fundacao Oswaldo Cruz, Campo Grande, MS, Brazil
hcfmusp.author.externalOLIVEIRA, Wanderson K. de:Coordenacao Geral Lab Saude Publ, Secretaria Vigilancia Saude, Minist Saude, Brasilia, DF, Brazil
hcfmusp.author.externalFILIPIS, Ana Maria Bispo de:Inst Oswaldo Cruz, Fundacao Oswaldo Cruz Fiocruz, Lab Flavivirus, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalCAMIS, Maria do Carmo Rodrigues dos Santos:Coordenadoria Controle Doencas Sao Paulo, Ctr Vigilancia Epidemiol Prof Alexandre Vranjac, Secretaria Estado Saude, Sao Paulo, SP, Brazil
hcfmusp.author.externalLOMAN, Nick J.:Univ Birmingham, Sch Biosci, Inst Microbiol & Infect, Birmingham, W Midlands, England
hcfmusp.author.externalPYBUS, Oliver G.:Univ Oxford, Dept Zool, Oxford, England
hcfmusp.author.externalNOGUEIRA, Mauricio L.:Fac Med Sao Jose do Rio Preto, Lab Pesquisa Virol, Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalFARIA, Nuno Rodrigues:Univ Sao Paulo, Inst Med Trop, Sao Paulo, SP, Brazil; Univ Oxford, Dept Zool, Oxford, England
hcfmusp.citation.scopus22
hcfmusp.contributor.author-fmusphcJAQUELINE GOES DE JESUS
hcfmusp.contributor.author-fmusphcFLAVIA CRISTINA DA SILVA SALES
hcfmusp.contributor.author-fmusphcINGRA MORALES CLARO
hcfmusp.contributor.author-fmusphcALVINA CLARA FELIX
hcfmusp.contributor.author-fmusphcCAMILA MALTA ROMANO
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.description.articlenumbere190423
hcfmusp.description.volume115
hcfmusp.origemWOS
hcfmusp.origem.pubmed32428189
hcfmusp.origem.scieloSCIELO:S0074-02762020000100317
hcfmusp.origem.scopus2-s2.0-85084962112
hcfmusp.origem.wosWOS:000537066200001
hcfmusp.publisher.cityRIO DE JANEIRO, RJeng
hcfmusp.publisher.countryBRAZILeng
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