Transcriptomic analysis reveals a tissue-specific loss of identity during ageing and cancer

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art_SANTOS_Transcriptomic_analysis_reveals_a_tissuespecific_loss_of_identity_2023.PDF (2.35 MB)
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0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
BMC
Autores
CHATSIRISUPACHAI, Kasit
AVELAR, Roberto A.
MAGALHAES, Joao Pedro de
Citação
BMC GENOMICS, v.24, n.1, article ID 644, 13p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
IntroductionUnderstanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes in human tissues are associated with tissue specificity during cancer and ageing using transcriptome data from TCGA and GTEx.ResultsWe found significant downregulation of tissue-specific genes during ageing in 40% of the tissues analyzed, which suggests loss of tissue identity with age. For most cancer types, we have noted a consistent pattern of downregulation in genes that are specific to the tissue from which the tumor originated. Moreover, we observed in cancer an activation of genes not usually expressed in the tissue of origin as well as an upregulation of genes specific to other tissues. These patterns in cancer were associated with patient survival. The age of the patient, however, did not influence these patterns.ConclusionWe identified loss of cellular identity in 40% of the tissues analysed during human ageing, and a clear pattern in cancer, where during tumorigenesis cells express genes specific to other organs while suppressing the expression of genes from their original tissue. The loss of cellular identity observed in cancer is associated with prognosis and is not influenced by age, suggesting that it is a crucial stage in carcinogenesis.
Palavras-chave
Functional genomics, Geriatric oncology, Geroscience, Oncogenomics
URI
https://observatorio.fm.usp.br/handle/OPI/57628
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Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - LIM/55
Artigos e Materiais de Revistas Científicas - ODS/03