Exercise in a Child with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPRADO, Danilo M.
dc.contributor.authorGUALANO, Bruno
dc.contributor.authorPINTO, Ana Lucia S.
dc.contributor.authorSALLUM, Adriana M.
dc.contributor.authorPERONDI, Maria B.
dc.contributor.authorROSCHEL, Hamilton
dc.contributor.authorSILVA, Clovis Artur
dc.date.accessioned2017-11-27T16:38:28Z
dc.date.available2017-11-27T16:38:28Z
dc.date.issued2011
dc.description.abstractPRADO, D. M., B. GUALANO, A. L. S. PINTO, A. M. SALLUM, M. B. PERONDI, H. ROSCHEL, and C. A. SILVA. Exercise in a Child with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. Med. Sci. Sports Exerc., Vol. 43, No. 12, pp. 2221-2223, 2011. Exercise training has emerged as a potential therapeutic strategy to counteract the decline in physical function and aerobic capacity in pediatric rheumatic disease. Purpose: We report for the first time on the effects of exercise training in juvenile systemic lupus erythematosus (JSLE) and antiphospholipid syndrome (APS). Methods: A 15-yr-old boy with JSLE and APS treated with warfarin, azathioprine, and prednisone underwent a 12-wk aerobic exercise training program to improve his physical capacity and functioning. Before and after the 12-wk exercise program, the patient was submitted to incremental cardiopulmonary tests to determine (V) over dotO(2peak), peak and submaximal exercise intensity, and time to exhaustion. In addition, a 6-min square-wave test was performed for assessing metabolic parameters. Functioning was assessed by using the visual analog scale. Laboratory parameters of inflammation were also assessed at baseline and 48 h after the last training session. Results: All the cardiopulmonary parameters (e. g., (V) over dotO(2max) = +36.0%, time to exhaustion = +67.8%, peak exercise intensity = +16.7%) and the metabolic cost of movement (e. g., energy expenditure = -28.3% to -33.3%, (V) over dotO(2) = -29.3% to -33.4%) were improved. Both disease activity and cumulative damage scores did not change after the intervention, and no evidence of exercise-induced exacerbation of inflammation was observed. Visual analog scale scores were also improved according to the patients' evaluation (before intervention = 8 vs after intervention = 10), parents' evaluation (before intervention = 8 vs after intervention = 10), and physicians' evaluation (before intervention = 6 vs after intervention = 9). Conclusions: This is the first evidence that a 12-wk supervised aerobic training program can be safe and effective in improving aerobic conditioning and physical function in a patient with JSLE and APS. In light of these findings, the therapeutic effects of exercise training in pediatric rheumatic diseases merit further investigations.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2010/51428-2, 08/58238-4]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico [300248/2008-3]
dc.description.sponsorshipFederico Foundation
dc.identifier.citationMEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v.43, n.12, p.2221-2223, 2011
dc.identifier.doi10.1249/MSS.0b013e318223b177
dc.identifier.issn0195-9131
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23637
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofMedicine and Science in Sports and Exercise
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectAEROBIC TRAINING
dc.subjectJUVENILE SYSTEMIC LUPUS ERYTHEMATOSUS
dc.subjectTHERAPEUTIC EFFECTS
dc.subjectPEDIATRIC RHEUMATIC DISEASES
dc.subject.otherclassification
dc.subject.othercriteria
dc.subject.otherfitness
dc.subject.othertrial
dc.subject.wosSport Sciences
dc.titleExercise in a Child with Systemic Lupus Erythematosus and Antiphospholipid Syndrome
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSALLUM, Adriana M.:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
hcfmusp.author.externalPERONDI, Maria B.:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil
hcfmusp.author.externalROSCHEL, Hamilton:Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil; Univ Sao Paulo, Sch Med, Div Rheumatol, Sao Paulo, Brazil
hcfmusp.citation.scopus10
hcfmusp.contributor.author-fmusphcDANILO MARCELO LEITE DO PRADO
hcfmusp.contributor.author-fmusphcBRUNO GUALANO
hcfmusp.contributor.author-fmusphcANA LUCIA DE SA PINTO
hcfmusp.contributor.author-fmusphcCLOVIS ARTUR ALMEIDA DA SILVA
hcfmusp.description.beginpage2221
hcfmusp.description.endpage2223
hcfmusp.description.issue12
hcfmusp.description.volume43
hcfmusp.origemWOS
hcfmusp.origem.pubmed21606873
hcfmusp.origem.scopus2-s2.0-81355138839
hcfmusp.origem.wosWOS:000297251100001
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-17
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