Chagas' cardiomyopathy: The economic burden of an expensive and neglected disease

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorABUHAB, Abrao
dc.contributor.authorTRINDADE, Evelinda
dc.contributor.authorAULICINO, Gabriel Barros
dc.contributor.authorFUJII, Sandra
dc.contributor.authorBOCCHI, Edimar Alcides
dc.contributor.authorBACAL, Fernando
dc.date.accessioned2014-01-28T22:19:21Z
dc.date.available2014-01-28T22:19:21Z
dc.date.issued2013
dc.description.abstractBackground: Chagas' cardiomyopathy (CC) is a rising etiology for heart failure (HF) that previously was restricted to some countries of Latin America. The chronic CC cases cause now a profound socio-economic impact. However this issue has not been well studied if compared to other causes of HF. The objective of this study was to assess the cost burden of CC during acute decompensated HF admissions (ADHF), and compare this cost to the other etiologies of HF. Methods and results: By the end of 2006 we started a five year follow-up of 577 consecutive adult patients admitted at a high complexity cardiology university hospital in the city of Sao Paulo, Brazil. This study shows the data of the first admission of each patient of this follow-up. Patients were divided in two groups: CC (58 patients) and non-chagasic (NC) (519 patients). Mortality was different among groups, 19/58 (32.8%) in CC vs 113/519 (21.8%) in NC (p=0.046). The prevalence of signs of inadequate perfusion was higher in the CC group at admission, but in a multivariated analysis chagasic etiology and presence of diabetes were independent predictors of higher costs per day of hospitalization adjusted by mortality. Median costs per day were US$308 (277-542) vs US$467 (323-815) for NC and CC respectively (p<0.001). Conclusion: Treating ADHF patients with CC etiology was more expensive and mortality was higher in this population at the first admission of this follow-up. This could be explained by the severity of Chagas' cardiomyopathy disease.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL JOURNAL OF CARDIOLOGY, v.168, n.3, p.2375-2380, 2013
dc.identifier.doi10.1016/j.ijcard.2013.01.262
dc.identifier.issn0167-5273
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3952
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofInternational Journal of Cardiology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER IRELAND LTD
dc.subjectChagas' cardiomyopathy
dc.subjectEconomic burden
dc.subjectNeglected disease
dc.subject.otherdecompensated heart-failure
dc.subject.otherrandomized controlled trial
dc.subject.otherdiagnosis
dc.subject.otherrisk
dc.subject.otherguidelines
dc.subject.othercharlson
dc.subject.otheradhere
dc.subject.otherbrazil
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleChagas' cardiomyopathy: The economic burden of an expensive and neglected disease
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalAULICINO, Gabriel Barros:Univ Sao Paulo, Sch Med, Heart Inst InCor, Heart Failure Dept, Sao Paulo, Brazil
hcfmusp.citation.scopus48
hcfmusp.contributor.author-fmusphcABRAO ABUHAB
hcfmusp.contributor.author-fmusphcEVELINDA MARRAMON TRINDADE
hcfmusp.contributor.author-fmusphcSANDRA MARI FUJII
hcfmusp.contributor.author-fmusphcEDIMAR ALCIDES BOCCHI
hcfmusp.contributor.author-fmusphcFERNANDO BACAL
hcfmusp.description.beginpage2375
hcfmusp.description.endpage2380
hcfmusp.description.issue3
hcfmusp.description.volume168
hcfmusp.origemWOS
hcfmusp.origem.pubmed23465560
hcfmusp.origem.scopus2-s2.0-84885599302
hcfmusp.origem.wosWOS:000326184400106
hcfmusp.publisher.cityCLARE
hcfmusp.publisher.countryIRELAND
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