Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNAGAI, Maria Aparecida
dc.date.accessioned2016-07-04T13:54:18Z
dc.date.available2016-07-04T13:54:18Z
dc.date.issued2016
dc.description.abstractPleckstrin homology-like domain, family A, member 1 (PHLDA1) encodes a member of an evolutionarily conserved pleckstrin homology-related domain protein family. It was first identified as a potential transcription factor required for Fas expression and activation-induced apoptosis in mouse T cell hybridomas. The exact molecular and biological functions of PHLDA1 remain to be elucidated. However, its expression is induced by a variety of external stimuli and there is evidence that it may function as a transcriptional activator that acts as a mediator of apoptosis, proliferation, differentiation and cell migration dependent on the cellular type and context. Recently, PHLDA1 has received attention due to its association with cancer. In the present review, the current knowledge of PHLDA1 protein structure, expression regulation and function is summarized. In addition, the current data in the literature is reviewed with regards to the role of PHLDA1 in cancer pathogenesis.
dc.description.indexPubMed
dc.identifier.citationBIOMEDICAL REPORTS, v.4, n.3, p.275-281, 2016
dc.identifier.doi10.3892/br.2016.580
dc.identifier.eissn2049-9442
dc.identifier.issn2049-9434
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/13903
dc.language.isoeng
dc.publisherSPANDIDOS PUBL LTD
dc.relation.ispartofBiomedical Reports
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPANDIDOS PUBL LTD
dc.subjectPHLDA1
dc.subjectpleckstrin homology-like
dc.subjectcancer
dc.subjecttumor suppressor gene
dc.subjectoncogene
dc.subjectdownregulation
dc.subjectstem cell
dc.subject.otherapoptosis in-vivo
dc.subject.otherbreast-cancer
dc.subject.othercell-death
dc.subject.othermesenchymal transition
dc.subject.othergene-expression
dc.subject.otherdown-regulation
dc.subject.othertdag51
dc.subject.otherprotein
dc.subject.othercontributes
dc.subject.othersurvival
dc.subject.wosMedicine, Research & Experimental
dc.titlePleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus50
hcfmusp.contributor.author-fmusphcMARIA APARECIDA NAGAI
hcfmusp.description.beginpage275
hcfmusp.description.endpage281
hcfmusp.description.issue3
hcfmusp.description.volume4
hcfmusp.origemWOS
hcfmusp.origem.pubmed26998263
hcfmusp.origem.scopus2-s2.0-85006403446
hcfmusp.origem.wosWOS:000370148000004
hcfmusp.publisher.cityATHENS
hcfmusp.publisher.countryGREECE
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