Lifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLOUREIRO, Camila Marcelino
dc.contributor.authorCORSI-ZUELLI, Fabiana
dc.contributor.authorFACHIM, Helene Aparecida
dc.contributor.authorSHUHAMA, Rosana
dc.contributor.authorOLIVEIRA, Adrielle Martins de
dc.contributor.authorMENEZES, Paulo Rossi
dc.contributor.authorDALTON, Caroline F.
dc.contributor.authorLOUZADA-JUNIOR, Paulo
dc.contributor.authorBELANGERO, Sintia Iole
dc.contributor.authorCOELI-LACCHINI, Fernanda
dc.contributor.authorREYNOLDS, Gavin P.
dc.contributor.authorLACCHINI, Riccardo
dc.contributor.authorDEL-BEN, Cristina Marta
dc.date.accessioned2023-10-30T14:39:28Z
dc.date.available2023-10-30T14:39:28Z
dc.date.issued2023
dc.description.abstractObjectives: Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and cannabinoid receptor type 1 (CB1R), lifetime cannabis use, and childhood trauma.Methods: Twenty-three SNVs of genes encoding D2R (DRD2: rs1799978, rs7131056, rs6275), NMDAR (GRIN1: rs4880213, rs11146020; GRIN2A: rs1420040, rs11866328; GRIN2B: rs890, rs2098469, rs7298664), and CB1R (CNR1: rs806380, rs806379, rs1049353, rs6454674, rs1535255, rs2023239, rs12720071, rs6928499, rs806374, rs7766029, rs806378, rs10485170, rs9450898) were genotyped in 143 first-episode psychosis patients (FEPp) and 286 communitybased controls by Illumina HumanCoreExome-24 BeadChip. Gene-gene and gene-environment associations were assessed using nonparametric Multifactor Dimensionality Reduction software.Results: Single-locus analyses among the 23 SNVs for psychosis and gene-gene interactions were not significant (p 4 0.05 for all comparisons); however, both environmental risk factors showed an association with psychosis (p < 0.001). Moreover, gene-environment interactions were significant for an SNV in CNR1 and cannabis use. The best-performing model was the combination of CNR1 rs12720071 and lifetime cannabis use (p < 0.001), suggesting an increased risk of psychosis.Conclusion: Our study supports the hypothesis of gene-environment interactions for psychosis involving T-allele carriers of CNR1 SNVs, childhood trauma, and cannabis use.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipFundacao de Amparo a~Pesquisa do Estado de Sao Paulo (FAPESP) [2012/05178-0, 2013/08216-2]
dc.description.sponsorshipFAPESP [2021/07448-3, 2019/13229-2, 2017/00624-5, 2015/02948-7, 2013/11167-3]
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [2020/15752-1]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.identifier.citationBRAZILIAN JOURNAL OF PSYCHIATRY, v.45, n.3, p.226-235, 2023
dc.identifier.doi10.47626/1516-4446-2022-2882
dc.identifier.eissn1809-452X
dc.identifier.issn1516-4446
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/56156
dc.language.isoeng
dc.publisherASSOC BRASILEIRA PSIQUIATRIAeng
dc.relation.ispartofBrazilian Journal of Psychiatry
dc.rightsopenAccesseng
dc.rights.holderCopyright ASSOC BRASILEIRA PSIQUIATRIAeng
dc.subjectCannabis useeng
dc.subjectchildhood traumaeng
dc.subjectfirst-episode psychosiseng
dc.subjectsingle nucleotide variantseng
dc.subject.othermultifactor dimensionality reductioneng
dc.subject.othermajor depressive disordereng
dc.subject.otherschizophreniaeng
dc.subject.otherassociationeng
dc.subject.otherpharmacogeneticseng
dc.subject.otherpolymorphismseng
dc.subject.othervalidationeng
dc.subject.otherreceptorseng
dc.subject.otherbiologyeng
dc.subject.wosPsychiatryeng
dc.titleLifetime cannabis use and childhood trauma increase risk of psychosis in carriers of CNR1 genetic variants: findings from the STREAM studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalLOUREIRO, Camila Marcelino:Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil; Ctr Pesquisas Saode Mental Populacao, Sao Paulo, SP, Brazil; Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, Ave Bandeirantes 3900, BR-14040900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalCORSI-ZUELLI, Fabiana:Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalFACHIM, Helene Aparecida:Univ Manchester, Manchester, England
hcfmusp.author.externalSHUHAMA, Rosana:Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil; Ctr Pesquisas Saode Mental Populacao, Sao Paulo, SP, Brazil
hcfmusp.author.externalOLIVEIRA, Adrielle Martins de:Univ Fed Sao Paulo, Sao Paulo, SP, Brazil
hcfmusp.author.externalDALTON, Caroline F.:Sheffield Hallam Univ, South Yorkshire, England
hcfmusp.author.externalBELANGERO, Sintia Iole:Univ Fed Sao Paulo, Sao Paulo, SP, Brazil
hcfmusp.author.externalCOELI-LACCHINI, Fernanda:Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, SP, Brazil
hcfmusp.author.externalREYNOLDS, Gavin P.:Sheffield Hallam Univ, South Yorkshire, England
hcfmusp.author.externalLACCHINI, Riccardo:Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalDEL-BEN, Cristina Marta:Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil; Ctr Pesquisas Saode Mental Populacao, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcPAULO ROSSI MENEZES
hcfmusp.description.beginpage226
hcfmusp.description.endpage235
hcfmusp.description.issue3
hcfmusp.description.volume45
hcfmusp.origemWOS
hcfmusp.origem.pubmed36918037
hcfmusp.origem.scieloSCIELO:S1516-44462023000300226
hcfmusp.origem.scopus2-s2.0-85164457832
hcfmusp.origem.wosWOS:001026620900003
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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