Relationship between glycemic control and coronary artery disease severity, prevalence and plaque characteristics by computed tomography coronary angiography in asymptomatic type 2 diabetic patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTAVARES, C. A. F.
dc.contributor.authorRASSI, C. H. R. E.
dc.contributor.authorFAHEL, M. G.
dc.contributor.authorWAJCHENBERG, B. L.
dc.contributor.authorROCHITTE, C. E.
dc.contributor.authorLERARIO, A. C.
dc.date.accessioned2016-12-20T16:36:01Z
dc.date.available2016-12-20T16:36:01Z
dc.date.issued2016
dc.description.abstractEvaluate whether glycemic control in type 2 diabetes (DM2) asymptomatic for coronary artery disease (CAD) affects not only the presence and magnitude of CAD but also the characteristics of plaque vulnerability using multidetector row computed coronary tomography (MDCT). Acute coronary syndrome (ACS) is frequently observed in asymptomatic DM2 patients. Positive vessel remodeling (PR) and low-attenuation plaques (LAP) identified by MDCT have been demonstrated to be characteristics of subsequent culprit lesions of ACS. However, little is known regarding plaque characteristics in asymptomatic diabetic patients and their relationship with glycemic control. Ninety asymptomatic DM2 patients, aged 40-65 years old, underwent MDCT. The presence of atherosclerotic obstruction, defined as coronary stenosis aeyen50 %, and plaque characteristics were compared between two groups of patients with A1c < 7 and A1c aeyenaEuroe7 %. Of the 90 patients, 38 (42.2 %) presented with coronary atherosclerotic plaques, 11 had A1c < 7 % and 27 had A1c aeyenaEuroe7 % (p = 0.0006). Fourteen patients had significant lumen obstruction higher than 50 %: 3 in the A1c < 7 % group and 11 in the A1c aeyenaEuroe7 % group (p = 0.02). Non-calcified plaque was more prevalent in the A1c aeyenaEuroe7 % group (p = 0.005). In eleven patients, the simultaneous presence of two vulnerability plaque characteristics (PR and LAP) were observed more frequently in the A1c aeyenaEuroe7 group (n = 8) than in the A1c < 7 group (n = 3) (p = 0.04). Asymptomatic DM2 patients with A1c aeyenaEuroe7 % have a higher frequency of CAD and a higher proportion of vulnerable atherosclerotic coronary plaque by MDCT compared to patients with DM2 with A1c < 7 in our study.
dc.description.indexMEDLINE
dc.description.sponsorshipResearch Center-FAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Sao Paulo, SP, Brasil [10/51705-6]
dc.identifier.citationINTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, v.32, n.10, p.1577-1585, 2016
dc.identifier.doi10.1007/s10554-016-0942-9
dc.identifier.eissn1573-0743
dc.identifier.issn1569-5794
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16992
dc.language.isoeng
dc.publisherSPRINGER
dc.relation.ispartofInternational Journal of Cardiovascular Imaging
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER
dc.subjectMultislice computed tomography
dc.subjectType 2 diabetes mellitus
dc.subjectCoronary artery disease
dc.subject.otherprognostic value
dc.subject.otherct angiography
dc.subject.othermellitus
dc.subject.wosCardiac & Cardiovascular Systems
dc.subject.wosRadiology, Nuclear Medicine & Medical Imaging
dc.titleRelationship between glycemic control and coronary artery disease severity, prevalence and plaque characteristics by computed tomography coronary angiography in asymptomatic type 2 diabetic patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalTAVARES, C. A. F.:Univ Sao Paulo, Inst Heart, Inst Coracao InCor,Diabet Grp, Nucleo Diabet & Doenca,Cardiovasc,Cerqueira Cesar, Ave Dr Eneas de Carvalho Aguiar 44,Andar AB, BR-05403000 Sao Paulo, SP, Brazil; Univ Sao Paulo, Endocrinol Course LIM 25, Clin Hosp,Med Sch, Nucleo Diabet & Doenca,Cardiovasc,Cerqueira Cesar, Ave Dr Eneas de Carvalho Aguiar 44,Andar AB, BR-05403000 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcCARLOS HENRIQUE REIS ESSELIN RASSI
hcfmusp.contributor.author-fmusphcMATEUS GUIMARAES FAHEL
hcfmusp.contributor.author-fmusphcBERNARDO LEO WAJCHENBERG
hcfmusp.contributor.author-fmusphcCARLOS EDUARDO ROCHITTE
hcfmusp.contributor.author-fmusphcANTONIO CARLOS LERARIO
hcfmusp.description.beginpage1577
hcfmusp.description.endpage1585
hcfmusp.description.issue10
hcfmusp.description.volume32
hcfmusp.origemWOS
hcfmusp.origem.pubmed27432440
hcfmusp.origem.scopus2-s2.0-84978757640
hcfmusp.origem.wosWOS:000383831300014
hcfmusp.publisher.cityDORDRECHT
hcfmusp.publisher.countryNETHERLANDS
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