Anti-Lipoprotein Lipase Antibodies in Patients with Hypertriglyceridemia without Associated Autoimmune Disease

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCARVALHO, Jozelio Freire de
dc.contributor.authorVIANA, Vilma Santos Trindade
dc.contributor.authorBORBA NETO, Eduardo Ferreira
dc.contributor.authorSANTOS, Raul Dias
dc.contributor.authorBONFA, Eloisa
dc.date.accessioned2017-11-27T16:23:36Z
dc.date.available2017-11-27T16:23:36Z
dc.date.issued2011
dc.description.abstractBackground: Anti-lipoprotein lipase antibodies have been described in rare cases of patients with hypertriglyceridemia. However, no systematic study evaluating these antibodies in patients with this lipid abnormality has been undertaken. Objectives: To analyze the correlation of anti-lipoprotein lipase (anti-LPL) antibodies with other laboratory findings in patients with hypertriglyceridemia but no autoimmune disease. Methods: We evaluated 44 hypertriglyceridemic patients without autoimmune disease. Clinical and laboratory evaluations included analyses of comorbidities, fasting lipid profile and anti-LPL antibodies. Results: Mean patient age was 55 +/- 10 years; 46% of the patients were female and 64% were Caucasian. The mean disease duration was 94.4 months and mean body mass index 28.7 +/- 3.6 kg/m(2); 34.0% were diabetic, 25.0% were obese, 72.7% had systemic arterial hypertension, 75% were sedentary, 15.9% were smokers, 56.8% had a family history of dyslipidemia, 45.5% had a family history of coronary insufficiency, 20.5% had acute myocardial infarction, 9.0% had undergone revascularization and 11.0% angioplasty, 79.5% were being treated with statins and 43.2% were taking fibrates. Median triglyceride levels were 254 mg/dl (range 100-3781 mg/dl), and total cholesterol level was 233 +/- 111 mg/dl. High-density lipoprotein was 42.6 +/- 15.4 mg/dl, low-density lipoprotein 110.7 +/- 42.4 mg/dl and very low-density lipoprotein 48 +/- 15 mg/dl. Anti-LPL antibodies were identified in 2 patients (4.5%), both of whom had a family history of dyslipidemia, coronary insufficiency and acute myocardial infarction; one had undergone myocardial revascularization and percutaneous transluminal coronary angioplasty, and both were using fibrates and had normal triglyceride levels. Conclusions: Our findings demonstrate a correlation between the immune response and dyslipoproteinemia in hypertriglyceridemic patients, suggesting that autoimmune disease contributes to the dyslipidemia process.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [02/03867-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, National Council for Scientific and Technological Development) [304756/2003-2, 300665/2009-1]
dc.description.sponsorshipFederico Foundation
dc.identifier.citationISRAEL MEDICAL ASSOCIATION JOURNAL, v.13, n.6, p.350-353, 2011
dc.identifier.issn1565-1088
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22642
dc.language.isoeng
dc.publisherISRAEL MEDICAL ASSOC JOURNAL
dc.relation.ispartofIsrael Medical Association Journal
dc.rightsopenAccess
dc.rights.holderCopyright ISRAEL MEDICAL ASSOC JOURNAL
dc.subjectlipoprotein lipase
dc.subjectanti-lipoprotein lipase
dc.subjectatherosclerosis
dc.subjecthypertriglyceridemia
dc.subjectdyslipidemia
dc.subject.othersystemic-lupus-erythematosus
dc.subject.otheri hyperlipoproteinemia
dc.subject.otherhyperchylomicronemia
dc.subject.othercholesterol
dc.subject.otherhyperlipidemia
dc.subject.otherenzyme
dc.subject.wosMedicine, General & Internal
dc.titleAnti-Lipoprotein Lipase Antibodies in Patients with Hypertriglyceridemia without Associated Autoimmune Disease
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcJOZELIO FREIRE DE CARVALHO
hcfmusp.contributor.author-fmusphcVILMA DOS SANTOS TRINDADE VIANA
hcfmusp.contributor.author-fmusphcEDUARDO FERREIRA BORBA NETO
hcfmusp.contributor.author-fmusphcRAUL DIAS DOS SANTOS FILHO
hcfmusp.contributor.author-fmusphcELOISA SILVA DUTRA DE OLIVEIRA BONFA
hcfmusp.description.beginpage350
hcfmusp.description.endpage353
hcfmusp.description.issue6
hcfmusp.description.volume13
hcfmusp.origemWOS
hcfmusp.origem.pubmed21809732
hcfmusp.origem.scopus2-s2.0-79959926663
hcfmusp.origem.wosWOS:000292489500007
hcfmusp.publisher.cityRAMAT GAN
hcfmusp.publisher.countryISRAEL
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