Radionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planning

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSAPIENZA, Marcelo Tatit
dc.contributor.authorWILLEGAIGNON, Jose
dc.date.accessioned2019-09-23T14:16:15Z
dc.date.available2019-09-23T14:16:15Z
dc.date.issued2019
dc.description.abstractThe efficacy and toxicity of radionuclide therapy are believed to be directly related to the radiation doses received by target tissues; however, nuclear medicine therapy continues to be based primarily on the administration of empirical activities to patients and less frequently on the use of internal dosimetry for individual therapeutic planning. This review aimed to critically describe the techniques and clinical evidence of dosimetry as a tool for therapeutic planning and the main limitations to its implementation in clinical practice. The present article is a nonsystematic review of voxel-based dosimetry. Clinical evidence pointing to a correlation between the radiation dose and therapeutic response in various diseases, such as thyroid carcinoma, neuroendocrine tumors and prostate cancer, is reviewed. Its limitations include technical aspects related to image acquisition and processing and the lack of randomized clinical trials demonstrating the impact of dosimetry on patient therapy. A more widespread use of dosimetry in therapeutic planning involves the development of user-friendly dosimetric protocols and confirmation that dose estimation implies good efficacy and low treatment-related toxicity.eng
dc.description.indexMEDLINEeng
dc.identifier.citationCLINICS, v.74, article ID e835, 8p, 2019
dc.identifier.doi10.6061/clinics/2019/e835
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33461
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULOeng
dc.relation.ispartofClinics
dc.rightsopenAccesseng
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULOeng
dc.subjectNuclear Medicineeng
dc.subjectRadionuclide Imagingeng
dc.subjectIn vivo Dosimetryeng
dc.subject.otherdifferentiated thyroid-cancereng
dc.subject.otherpatient-specific dosimetryeng
dc.subject.otheri-124 peteng
dc.subject.otherimage quantificationeng
dc.subject.otherradioiodine therapyeng
dc.subject.otherradioembolizationeng
dc.subject.othercarcinomaeng
dc.subject.othersurvivaleng
dc.subject.otheri-131-metaiodobenzylguanidineeng
dc.subject.otherneuroblastomaeng
dc.subject.wosMedicine, General & Internaleng
dc.titleRadionuclide therapy: current status and prospects for internal dosimetry in individualized therapeutic planningeng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcMARCELO TATIT SAPIENZA
hcfmusp.contributor.author-fmusphcJOSE WILLEGAIGNON DE AMORIM DE CARVALHO
hcfmusp.description.articlenumbere835
hcfmusp.description.volume74
hcfmusp.origemWOS
hcfmusp.origem.pubmed31365617
hcfmusp.origem.scieloSCIELO:S1807-59322019000100308
hcfmusp.origem.scopus2-s2.0-85070888350
hcfmusp.origem.wosWOS:000478037700001
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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