Assessment of Adherence to Prescribed Therapy in Patients with Chronic Hepatitis B

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Arquivos
art_ABREU_Assessment_of_Adherence_to_Prescribed_Therapy_in_Patients_2016.PDF (659.98 KB)
Citações na Scopus
6
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER LONDON LTD
Autores
FERREIRA, Camila da Silva
FERREIRA, Aline Siqueira
REMOR, Eduardo
Citação
INFECTIOUS DISEASES AND THERAPY, v.5, n.1, p.53-64, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Evidence shows that treatment for hepatitis B virus (HBV) can suppress viral load. Among the factors directly linked to therapeutic success is adherence to the treatment. Several instruments to assess adherence are available, but they are not validated for use in chronic hepatitis B. The purpose of this paper was to adapt and validate the ""Assessment of Adherence to Antiretroviral Therapy Questionnaire-HIV"" (CEAT-VIH) for patients with chronic hepatitis B (referred to herein as CEAT-HBV). The validity of the adapted questionnaire evidence was established through concurrent, criterion, and construct validities. We found negative and significant correlation between the domain ""degree of compliance to antiviral therapy"" assessed by CEAT-HBV and the Morisky test (r = -0.62, P < 0.001) and between the domain ""barriers to adherence"" and HBV viral load (r = -0.42, P < 0.001). In terms of the construct's discriminative capacity, scores greater than or equal to 80 detected antiviral therapy success, which are necessary for the prediction of an undetectable HBV viral load. Thus, a cutoff value of 80.5 was set with a value of 81% for sensitivity and 67% for specificity. The CEAT-HBV identified 43% (n = 79) non-adherent patients and was shown to be a useful tool in clinical practice.
Palavras-chave
Assessment tool, Chronic disease, Hepatitis B, Patient adherence, Questionnaire
URI
https://observatorio.fm.usp.br/handle/OPI/18830
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MGT
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/07
Artigos e Materiais de Revistas Científicas - ODS/03