A comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFUCHS, Flavio D.
dc.contributor.authorFUCHS, Sandra C.
dc.contributor.authorMOREIRA, Leila B.
dc.contributor.authorGUS, Miguel
dc.contributor.authorNOBREGA, Antonio C.
dc.contributor.authorPOLI-DE-FIGUEIREDO, Carlos E.
dc.contributor.authorMION, Decio
dc.contributor.authorBORTOLOTTO, Luiz
dc.contributor.authorCONSOLIM-COLOMBO, Fernanda
dc.contributor.authorNOBRE, Fernando
dc.contributor.authorCOELHO, Eduardo Barbosa
dc.contributor.authorVILELA-MARTIN, Jose F.
dc.contributor.authorMORENO JR., Heitor
dc.contributor.authorCESARINO, Evandro Jose
dc.contributor.authorFRANCO, Roberto
dc.contributor.authorBRANDAO, Andrea Araujo
dc.contributor.authorSOUSA, Marcos R. de
dc.contributor.authorRIBEIRO, Antonio Luiz Pinho
dc.contributor.authorJARDIM, Paulo Cesar
dc.contributor.authorAFIUNE NETO, Abrahao
dc.contributor.authorSCALA, Luiz Cesar N.
dc.contributor.authorMOTA, Marco
dc.contributor.authorCHAVES, Hilton
dc.contributor.authorALVES, Joao Guilherme
dc.contributor.authorSOBRAL FILHO, Dario C.
dc.contributor.authorSILVA, Ricardo Pereira e
dc.contributor.authorFIGUEIREDO NETO, Jose A.
dc.contributor.authorIRIGOYEN, Maria Claudia
dc.contributor.authorCASTRO, Iran
dc.contributor.authorSTEFFENS, Andre Avelino
dc.contributor.authorSCHLATTER, Rosane
dc.contributor.authorMELLO, Renato Bandeira de
dc.contributor.authorMOSELE, Francisca
dc.contributor.authorGHIZZONI, Flavia
dc.contributor.authorBERWANGER, Otavio
dc.date.accessioned2017-11-27T16:38:31Z
dc.date.available2017-11-27T16:38:31Z
dc.date.issued2011
dc.description.abstractBackground: Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics are as efficacious as other agents, are well tolerated, have longer duration of action and low cost, but have been scarcely compared with ARBs. A study comparing diuretic and ARB is therefore warranted. Methods/design: This is a randomized, double-blind, clinical trial, comparing the association of chlorthalidone and amiloride with losartan as first drug option in patients aged 30 to 70 years, with stage I hypertension. The primary outcomes will be variation of blood pressure by time, adverse events and development or worsening of microalbuminuria and of left ventricular hypertrophy in the EKG. The secondary outcomes will be fatal or non-fatal cardiovascular events: myocardial infarction, stroke, heart failure, evidence of new subclinical atherosclerosis and sudden death. The study will last 18 months. The sample size will be of 1200 participants for group in order to confer enough power to test for all primary outcomes. The project was approved by the Ethics committee of each participating institution. Discussion: The putative pleiotropic effects of ARB agents, particularly renal protection, have been disputed, and they have been scarcely compared with diuretics in large clinical trials, despite that they have been at least as efficacious as newer agents in managing hypertension. Even if the null hypothesis is not rejected, the information will be useful for health care policy to treat hypertension in Brazil.
dc.description.indexMEDLINE
dc.description.sponsorshipDepartment of Science and Technology (DECIT)
dc.description.sponsorshipHealth Ministry
dc.description.sponsorshipCNPq
dc.description.sponsorshipFINEP
dc.description.sponsorshipScience and Technology Ministry
dc.description.sponsorshipFIPE
dc.description.sponsorshipHospital de Clinicas de Porto Alegre, Brazil
dc.identifier.citationTRIALS, v.12, article ID 53, 5p, 2011
dc.identifier.doi10.1186/1745-6215-12-53
dc.identifier.issn1745-6215
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/23654
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.relation.ispartofTrials
dc.rightsopenAccess
dc.rights.holderCopyright BIOMED CENTRAL LTD
dc.subject.otherconverting enzyme-inhibitor
dc.subject.otherlipid-lowering treatment
dc.subject.othercalcium-channel blocker
dc.subject.otherhigh-risk
dc.subject.otherenalapril
dc.subject.otheroutcomes
dc.subject.otherallhat
dc.subject.wosMedicine, Research & Experimental
dc.titleA comparison between diuretics and angiotensin-receptor blocker agents in patients with stage I hypertension (PREVER-treatment trial): study protocol for a randomized double-blind controlled trial
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalFUCHS, Flavio D.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalFUCHS, Sandra C.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalMOREIRA, Leila B.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalGUS, Miguel:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalNOBREGA, Antonio C.:Univ Fed Fluminense, Hosp Univ Antonio Pedro, Niteroi, RJ, Brazil
hcfmusp.author.externalPOLI-DE-FIGUEIREDO, Carlos E.:Pontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Porto Alegre, RS, Brazil
hcfmusp.author.externalNOBRE, Fernando:Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil
hcfmusp.author.externalCOELHO, Eduardo Barbosa:Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil
hcfmusp.author.externalVILELA-MARTIN, Jose F.:Fac Med Sao Jose Rio Preto, Sao Jose Do Rio Preto, Brazil
hcfmusp.author.externalMORENO JR., Heitor:Univ Estadual Campinas, Fac Ciencias Med, Campinas, SP, Brazil
hcfmusp.author.externalCESARINO, Evandro Jose:Univ Sao Paulo, Fac Ciencias Farmaceut, BR-14049 Ribeirao Preto, Brazil
hcfmusp.author.externalFRANCO, Roberto:Univ Estadual Sao Paulo, Fac Med Botucatu, Botucatu, SP, Brazil
hcfmusp.author.externalBRANDAO, Andrea Araujo:Univ Estado Rio de Janeiro, BR-20550011 Rio De Janeiro, Brazil
hcfmusp.author.externalSOUSA, Marcos R. de:Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil
hcfmusp.author.externalRIBEIRO, Antonio Luiz Pinho:Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil
hcfmusp.author.externalJARDIM, Paulo Cesar:Univ Fed Goias, Hosp Clin Goiania, Goiania, Go, Brazil
hcfmusp.author.externalAFIUNE NETO, Abrahao:Anis Rassi Hosp, Goiania, Go, Brazil
hcfmusp.author.externalSCALA, Luiz Cesar N.:Univ Fed Mato Grosso, Hosp Univ Julio Muller, Cuiaba, Brazil
hcfmusp.author.externalMOTA, Marco:Univ Ciencias Saude Alagoas, Fac Med, Maceio, Brazil
hcfmusp.author.externalCHAVES, Hilton:Univ Fed Pernambuco, Fac Med, Recife, PE, Brazil
hcfmusp.author.externalALVES, Joao Guilherme:Inst Med Integral Prof Fernando Figueira, Recife, PE, Brazil
hcfmusp.author.externalSOBRAL FILHO, Dario C.:Univ Pernambuco, Hosp Univ Oswaldo Cruz PROCAPE, Recife, PE, Brazil
hcfmusp.author.externalSILVA, Ricardo Pereira e:Univ Fed Ceara, Hosp Univ Valter Cantidio, Fortaleza, Ceara, Brazil
hcfmusp.author.externalFIGUEIREDO NETO, Jose A.:Univ Fed Maranhao, Univ Hosp, Sao Luis, Brazil
hcfmusp.author.externalIRIGOYEN, Maria Claudia:Fundacao Univ Cardiol, Inst Cardiol, Porto Alegre, RS, Brazil
hcfmusp.author.externalCASTRO, Iran:Fundacao Univ Cardiol, Inst Cardiol, Porto Alegre, RS, Brazil
hcfmusp.author.externalSTEFFENS, Andre Avelino:Univ Fed Pelotas, Fac Med, Pelotas, Brazil
hcfmusp.author.externalSCHLATTER, Rosane:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalMELLO, Renato Bandeira de:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalMOSELE, Francisca:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalGHIZZONI, Flavia:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
hcfmusp.author.externalBERWANGER, Otavio:Hosp Coracao, Sao Paulo, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcDECIO MION JUNIOR
hcfmusp.contributor.author-fmusphcLUIZ APARECIDO BORTOLOTTO
hcfmusp.contributor.author-fmusphcFERNANDA MARCIANO CONSOLIM COLOMBO
hcfmusp.description.articlenumber53
hcfmusp.description.volume12
hcfmusp.origemWOS
hcfmusp.origem.pubmed21349192
hcfmusp.origem.scopus2-s2.0-79951956492
hcfmusp.origem.wosWOS:000288423900001
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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hcfmusp.scopus.lastupdate2024-05-17
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