Obesity Facts and Their Influence on Renal Function Across the Life Span

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKOCH, Vera H.
dc.date.accessioned2022-02-24T17:21:07Z
dc.date.available2022-02-24T17:21:07Z
dc.date.issued2021
dc.description.abstractObesity is a chronic disease, with a rapidly increasing prevalence worldwide. Body mass index (BMI) provides the most useful population-level measure of overweight and obesity. For adults, overweight is defined as a BMI (Kg/m(2)) >= 25, and obesity as a BMI >= 30, for non-Asians and >= 27.5 for Asians. Abdominal obesity can be defined as a waist circumference equal to or higher than 102 cm for men and >= 88 cm for women. The definition of children and adolescents BMI changes with age and sex. Obesity may be exogenous or endogenous obesity, the latter is multifactorial and predominantly manifested during childhood. Presently, overweight and obesity are linked to more deaths worldwide than underweight. The total kidney glomerular filtration rate (GFR) is determined by the sum of nephrons and the GFR within each nephron or single nephron GFR. In clinical practice, GFR is more frequently calculated by GFR estimating equations based upon the plasma levels of creatinine, cystatin C, or both. The measured value of plasma creatinine is strongly influenced by non-GFR factors, by its tubular and gastrointestinal secretion, and by the problems associated with the lack of standardization of creatinine's laboratory assay discrediting it as an ideal GFR biomarker. Unlike creatinine, cystatin C plasma levels are mainly determined by GFR. Obesity may affect the kidney, via development of systemic arterial hypertension and/or diabetes mellitus, or directly, by ectopic accumulation of adipose tissue in the kidney. As obesity is a clinical condition associated with altered body composition, creatinine may not be the ideal biomarker for GFR measurement in obese individuals.eng
dc.description.indexPubMedeng
dc.identifier.citationFRONTIERS IN MEDICINE, v.8, article ID 704409, 10p, 2021
dc.identifier.doi10.3389/fmed.2021.704409
dc.identifier.eissn2296-858X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/44733
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Medicine
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectobesityeng
dc.subjectglomerular filtration rateeng
dc.subjectcreatinineeng
dc.subjectcystatin Ceng
dc.subjectpediatriceng
dc.subjectadulteng
dc.subject.otherglomerular-filtration-rateeng
dc.subject.otherchronic kidney-diseaseeng
dc.subject.otherplasma cystatin-ceng
dc.subject.othercreatinine-based equationeng
dc.subject.otherbody-mass indexeng
dc.subject.otherserum creatinineeng
dc.subject.otherwaist circumferenceeng
dc.subject.otherreference intervalseng
dc.subject.otherscreening tooleng
dc.subject.otherestimating gfreng
dc.subject.wosMedicine, General & Internaleng
dc.titleObesity Facts and Their Influence on Renal Function Across the Life Spaneng
dc.typearticleeng
dc.type.categoryrevieweng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus11
hcfmusp.contributor.author-fmusphcVERA HERMINA KALIKA KOCH
hcfmusp.description.articlenumber704409
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed34869407
hcfmusp.origem.scopus2-s2.0-85120671975
hcfmusp.origem.wosWOS:000726083300001
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
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