Hypotonic solution decreases serum sodium in infants with moderate bronchiolitis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRODRIGUES, Regina M.
dc.contributor.authorSCHVARTSMAN, Benita G. S.
dc.contributor.authorFARHAT, Sylvia C. L.
dc.contributor.authorSCHVARTSMAN, Claudio
dc.date.accessioned2014-04-28T22:07:38Z
dc.date.available2014-04-28T22:07:38Z
dc.date.issued2014
dc.description.abstractAimTo investigate the influence of hypotonic parenteral hydration on serum and urinary sodium and osmolality in infants with moderate bronchiolitis. MethodsWe studied 36 infants (mean age 3.72.3months), with a diagnosis of moderate bronchiolitis admitted to a paediatric emergency unit in SAo Paulo, Brazil. Patients received a standard parenteral hypotonic solution, according to Holliday and Segar, during the first 24h, due to respiratory distress. The disease was monitored by a respiratory severity score (RDAI-Respiratory Distress Assessment Instrument), respiratory rate and oxygen saturation. Serum and urinary sodium and osmolality were monitored at admission, 24 and 48h after admission. ResultsAll respiratory parameters improved during hospitalisation. Serum sodium and osmolality dropped after 24h (136.8 +/- 2.8 and 135.8 +/- 2.6mEq/L, p=0.031; 283.4 +/- 4.1 and 281.6 +/- 3.9 mOsm/kg, p=0.004 respectively) as well as urinary osmolality (486.8 +/- 243.4 mOsm/kg and 355.7 +/- 205.0 mOsm/kg, p<0.001) when compared to admission. ConclusionThis study reinforces the occurrence of hyponatraemia in bronchiolitis even in patients with moderate disease and highlights the risk of serum sodium drop caused by hypotonic parenteral hydration.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [09/09225-6]
dc.identifier.citationACTA PAEDIATRICA, v.103, n.3, p.E111-E115, 2014
dc.identifier.doi10.1111/apa.12493
dc.identifier.eissn1651-2227
dc.identifier.issn0803-5253
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5495
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofActa Paediatrica
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subjectHyponatraemia
dc.subjectHypotonic solution
dc.subjectModerate bronchiolitis
dc.subjectPaediatric
dc.subject.otherrespiratory syncytial virus
dc.subject.otherplacebo-controlled trial
dc.subject.otherhospitalized children
dc.subject.otherantidiuretic-hormone
dc.subject.otheracute hyponatremia
dc.subject.otherinfection
dc.subject.othersecretion
dc.subject.otherwater
dc.subject.othercomplications
dc.subject.otherepinephrine
dc.subject.wosPediatrics
dc.titleHypotonic solution decreases serum sodium in infants with moderate bronchiolitis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalRODRIGUES, Regina M.:Univ Sao Paulo, Fac Med, Hosp Clin, Emergency Dept,Inst Crianca, Sao Paulo, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcBENITA GALASSI SOARES SCHVARTSMAN
hcfmusp.contributor.author-fmusphcSYLVIA COSTA LIMA FARHAT
hcfmusp.contributor.author-fmusphcCLAUDIO SCHVARTSMAN
hcfmusp.description.beginpageE111
hcfmusp.description.endpageE115
hcfmusp.description.issue3
hcfmusp.description.volume103
hcfmusp.origemWOS
hcfmusp.origem.pubmed24188330
hcfmusp.origem.scopus2-s2.0-84893929578
hcfmusp.origem.wosWOS:000331270000007
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.scopus.lastupdate2024-05-10
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