Statin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | BRASILEIRO-SANTOS, Maria S. | |
dc.contributor.author | BARRETO-FILHO, Jose A. S. | |
dc.contributor.author | SANTOS, Raul D. | |
dc.contributor.author | CHACRA, Ana P. M. | |
dc.contributor.author | SANGALETI, Carine Teles | |
dc.contributor.author | ALVEZ, Gisele | |
dc.contributor.author | BEZERRA, Otavio Coelho | |
dc.contributor.author | BORTOLOTO, Luiz Aparecido | |
dc.contributor.author | IRIGOYEN, Maria C. | |
dc.contributor.author | CONSOLIM-COLOMBO, Fernanda M. | |
dc.date.accessioned | 2014-04-25T21:50:39Z | |
dc.date.available | 2014-04-25T21:50:39Z | |
dc.date.issued | 2013 | |
dc.description.abstract | BackgroundHypercholesterolaemia may alter cardiovascular autonomic function. We investigated the autonomic cardiovascular regulation during normoxia and hypoxia in familial isolated HC patients with or without statin treatment. Materials and methodsLow (LF-RR) and high (HF-RR) components of spectral analysis of RR interval and systolic arterial pressure (LF-SAP) were obtained during 5min of normoxia and isocapnic hypoxia (10% O-2) in 10 normotensive familial HC patients without medication, in seven HC patients after a 12-week treatment period with 40mg of simvastatin (HC+SVT) and in eight matched normal volunteers (CO). ResultsThe HC patients had significant impairment of cardiac autonomic modulation parameters compared with CO at normoxia, which was maintained or even accentuated during hypoxia; these parameters included lower total variance of RR, increased normalized LF-RR, decreased normalized HF-RR, increased LF-RR/HF-RR ratio, higher LF-SAP component and reduced index. However, the HC+SVT group had a significant improvement in all parameters: the LF-RR and LF-SAP decreased (indicating a decrease in cardiac and vascular sympathetic activity), the HF-RR increased (indicating an increase in parasympathetic activity) and the spontaneous baroreflex sensitivity improved. These changes were detected at normoxia and were maintained during hypoxia. ConclusionsOur data are the first to show that isolated HC is characterized by an increase in cardiac and vasomotor sympathetic drive, a decrease in cardiac vagal modulation and baroreflex impairment during normoxia and hypoxia. In addition, our data suggest that statin treatment has a potential role in restoring the physiological cardiovascular autonomic control at baseline and during cardiovascular challenge. | |
dc.description.index | MEDLINE | |
dc.description.sponsorship | FAPESP | |
dc.description.sponsorship | Fundacao Zerbini | |
dc.description.sponsorship | CNPq, Brazil | |
dc.identifier.citation | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v.43, n.12, p.1291-1298, 2013 | |
dc.identifier.doi | 10.1111/eci.12177 | |
dc.identifier.eissn | 1365-2362 | |
dc.identifier.issn | 0014-2972 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/5107 | |
dc.language.iso | eng | |
dc.publisher | WILEY-BLACKWELL | |
dc.relation.ispartof | European Journal of Clinical Investigation | |
dc.rights | restrictedAccess | |
dc.rights.holder | Copyright WILEY-BLACKWELL | |
dc.subject | Autonomic nervous system | |
dc.subject | blood pressure | |
dc.subject | hypercholesterolaemia | |
dc.subject | hypoxia | |
dc.subject | simvastatin | |
dc.subject.other | heart-rate-variability | |
dc.subject.other | familial hypercholesterolemia | |
dc.subject.other | sympathetic activation | |
dc.subject.other | atorvastatin | |
dc.subject.other | atherosclerosis | |
dc.subject.other | metaanalysis | |
dc.subject.other | dysfunction | |
dc.subject.other | diagnosis | |
dc.subject.other | pressure | |
dc.subject.other | disease | |
dc.subject.wos | Medicine, General & Internal | |
dc.subject.wos | Medicine, Research & Experimental | |
dc.title | Statin restores cardiac autonomic response to acute hypoxia in hypercholesterolaemia | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.author.external | BRASILEIRO-SANTOS, Maria S.:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Fed Sao Paulo UNIFESP, Sao Paulo, Brazil; Univ Fed Paraiba, BR-58059900 Joao Pessoa, Paraiba, Brazil | |
hcfmusp.author.external | BARRETO-FILHO, Jose A. S.:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Fed Sergipe, Aracaju, Brazil | |
hcfmusp.author.external | SANGALETI, Carine Teles:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Estadual Cent Oeste Parana, Guarapuava, Brazil | |
hcfmusp.author.external | ALVEZ, Gisele:Univ Sao Paulo, Inst Coracao InCor, Sao Paulo, Brazil; Univ Fed Sao Paulo UNIFESP, Sao Paulo, Brazil | |
hcfmusp.author.external | BEZERRA, Otavio Coelho:Univ Nove Julho UNINOVE, Sao Paulo, Brazil | |
hcfmusp.citation.scopus | 6 | |
hcfmusp.contributor.author-fmusphc | RAUL DIAS DOS SANTOS FILHO | |
hcfmusp.contributor.author-fmusphc | ANA PAULA MARTE CHACRA | |
hcfmusp.contributor.author-fmusphc | LUIZ APARECIDO BORTOLOTTO | |
hcfmusp.contributor.author-fmusphc | MARIA CLAUDIA COSTA IRIGOYEN | |
hcfmusp.contributor.author-fmusphc | FERNANDA MARCIANO CONSOLIM COLOMBO | |
hcfmusp.description.beginpage | 1291 | |
hcfmusp.description.endpage | 1298 | |
hcfmusp.description.issue | 12 | |
hcfmusp.description.volume | 43 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 24102438 | |
hcfmusp.origem.scopus | 2-s2.0-84888044421 | |
hcfmusp.origem.wos | WOS:000330101900008 | |
hcfmusp.publisher.city | HOBOKEN | |
hcfmusp.publisher.country | USA | |
hcfmusp.relation.reference | Allemann Y, 2012, AM J PHYSIOL-HEART C, V302, pH2646, DOI 10.1152/ajpheart.00053.2012 | |
hcfmusp.relation.reference | Barreto JAS, 2003, ARTERIOSCL THROM VAS, V23, P1660, DOI 10.1161/01.ATV.0000089471.61037.21 | |
hcfmusp.relation.reference | BASELLI G, 1986, COMPUT BIOMED RES, V19, P520, DOI 10.1016/0010-4809(86)90026-1 | |
hcfmusp.relation.reference | Briasoulis A, 2013, J CLIN HYPERTENS, V15, P310, DOI 10.1111/jch.12081 | |
hcfmusp.relation.reference | Brown SJ, 2013, EUR J APPL PHYSIOL, V113, P1731, DOI 10.1007/s00421-013-2601-3 | |
hcfmusp.relation.reference | Camm AJ, 1996, EUR HEART J, V17, P354 | |
hcfmusp.relation.reference | Chopra V, 2007, CARDIOVASC DRUG THER, V21, P161, DOI 10.1007/s10557-007-6025-3 | |
hcfmusp.relation.reference | Civeira F, 2004, ATHEROSCLEROSIS, V173, P55, DOI 10.1016/j.atherosclerosis.2003.11.010 | |
hcfmusp.relation.reference | Duplain H, 1999, CIRCULATION, V99, P1713 | |
hcfmusp.relation.reference | Floras JS, 2003, ACTA PHYSIOL SCAND, V177, P391, DOI 10.1046/j.1365-201X.2003.01087.x | |
hcfmusp.relation.reference | Gould AL, 2007, CLIN THER, V29, P778, DOI 10.1016/j.clinthera.2007.05.012 | |
hcfmusp.relation.reference | Haarala A, 2011, EUR J CLIN INVEST, V41, P951, DOI 10.1111/j.1365-2362.2011.02485.x | |
hcfmusp.relation.reference | Collins R, 2002, LANCET, V360, P7 | |
hcfmusp.relation.reference | HEISTAD DD, 1980, CIRCULATION, V61, P463 | |
hcfmusp.relation.reference | Hovingh GK, 2013, EUR HEART J, V34, P962, DOI 10.1093/eurheartj/eht015 | |
hcfmusp.relation.reference | Kastelein JJP, 2007, NEW ENGL J MED, V356, P1620, DOI 10.1056/NEJMoa071359 | |
hcfmusp.relation.reference | Klemenc M, 2011, EUR J APPL PHYSIOL, V111, P2509, DOI 10.1007/s00421-011-1875-6 | |
hcfmusp.relation.reference | Lahiri MK, 2008, J AM COLL CARDIOL, V51, P1725, DOI 10.1016/j.jacc.2008.01.038 | |
hcfmusp.relation.reference | Mason RP, 2004, CIRCULATION S1, V109, P1134 | |
hcfmusp.relation.reference | Melenovsky V, 2003, AM J CARDIOL, V92, P337, DOI 10.1016/S0002-9149(03)00543-X | |
hcfmusp.relation.reference | MONTANO N, 1994, CIRCULATION, V90, P1826 | |
hcfmusp.relation.reference | Pehlivanidis AN, 2001, ATHEROSCLEROSIS, V157, P463, DOI 10.1016/S0021-9150(00)00746-2 | |
hcfmusp.relation.reference | Rovere MT, 1988, CIRCULATION, V78, P816 | |
hcfmusp.relation.reference | Rovere MT, 2003, CIRCULATION, V107, P565 | |
hcfmusp.relation.reference | Sacks FM, 1996, NEW ENGL J MED, V335, P1001, DOI 10.1056/NEJM199610033351401 | |
hcfmusp.relation.reference | SOMERS VK, 1989, J APPL PHYSIOL, V67, P2101 | |
hcfmusp.relation.reference | Stapleton PA, 2010, J INFLAMM-LOND, V7, DOI 10.1186/1476-9255-7-54 | |
hcfmusp.relation.reference | STROES ESG, 1995, LANCET, V346, P467, DOI 10.1016/S0140-6736(95)91322-X | |
hcfmusp.relation.reference | Szramka M, 2007, INT J CARDIOL, V117, P287, DOI 10.1016/j.ijcard.2006.05.043 | |
hcfmusp.relation.reference | Vogel RA, 1997, CLIN CARDIOL, V20, P426 | |
hcfmusp.relation.reference | Wassmann S, 2001, HYPERTENSION, V37, P1450 | |
hcfmusp.remissive.sponsorship | CNPq | |
hcfmusp.remissive.sponsorship | FAPESP | |
hcfmusp.remissive.sponsorship | Fund Zerbini | |
hcfmusp.scopus.lastupdate | 2024-05-10 | |
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